Basal activation of p70S6K results in adipose-specific insulin resistance in protein-tyrosine phosphatase 1B -/- mice. (Q42516714)

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2 January 2020

title

Basal activation of p70S6K results in adipose-specific insulin resistance in protein-tyrosine phosphatase 1B -/- mice (English)

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2 January 2020

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2

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2 January 2020

author name string

Salvatore C Ruffolo

1

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2 January 2020

Xiling Yuan

3

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2 January 2020

Sylvie Desmarais

4

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2 January 2020

Jean Himms-Hagen

5

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2 January 2020

Wanda Cromlish

6

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2 January 2020

Kenny K Wong

7

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2 January 2020

Brian P Kennedy

8

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2 January 2020

language of work or name

English

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publication date

30 July 2007

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Journal of Biological Chemistry

2 January 2020

published in

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2 January 2020

volume

282

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2 January 2020

issue

42

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2 January 2020

page(s)

30423-30433

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Dynamics of the interaction between the insulin receptor and protein tyrosine-phosphatase 1B in living cells

2 January 2020

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Protein tyrosine phosphatase-1B dephosphorylation of the insulin receptor occurs in a perinuclear endosome compartment in human embryonic kidney 293 cells

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Sequential dephosphorylation of a multiply phosphorylated insulin receptor peptide by protein tyrosine phosphatases

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Molecular basis for the dephosphorylation of the activation segment of the insulin receptor by protein tyrosine phosphatase 1B

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Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene

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Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient mice

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Liver-specific protein-tyrosine phosphatase 1B (PTP1B) re-expression alters glucose homeostasis of PTP1B-/-mice

21 January 2018

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Transgenic overexpression of protein-tyrosine phosphatase 1B in muscle causes insulin resistance, but overexpression with leukocyte antigen-related phosphatase does not additively impair insulin action

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Overexpression of protein-tyrosine phosphatase-1B in adipocytes inhibits insulin-stimulated phosphoinositide 3-kinase activity without altering glucose transport or Akt/Protein kinase B activation

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Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

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Attenuation of leptin action and regulation of obesity by protein tyrosine phosphatase 1B.

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