Jump to content

Desmin (Q425146)

From Wikidata

mammalian protein found in Homo sapiens

DES
epididymis secretory sperm binding protein
intermediate filament protein
cardiomyopathy, dilated 1F (autosomal dominant)
desmin
mutant desmin p.K241E
uniprot:P17661

Language	Label	Description	Also known as
default for all languages	No label defined
English	Desmin	mammalian protein found in Homo sapiens	DES epididymis secretory sperm binding protein intermediate filament protein cardiomyopathy, dilated 1F (autosomal dominant) desmin mutant desmin p.K241E uniprot:P17661

Statements

1 reference

13 November 2019

UniProt protein ID

Intermediate filament head, DNA-binding domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Intermediate filament, rod domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Intermediate filament protein, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

protein binding

determination method or standard

12 references

8 April 2019

Nebulin binding impedes mutant desmin filament assembly

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17661

determination method or standard

8 April 2019

αB-crystallin is a sensor for assembly intermediates and for the subunit topology of desmin intermediate filaments.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17661

determination method or standard

8 April 2019

Desmuslin, an intermediate filament protein that interacts with alpha -dystrobrevin and desmin

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17661

determination method or standard

8 April 2019

Nebulette is a powerful cytolinker organizing desmin and actin in mouse hearts

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17661

determination method or standard

8 April 2019

Interactions between epiplakin and intermediate filaments

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17661

determination method or standard

8 April 2019

A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17661

determination method or standard

8 April 2019

Homologous Transcription Factors DUX4 and DUX4c Associate with Cytoplasmic Proteins during Muscle Differentiation

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17661

determination method or standard

8 April 2019

Myotubularin controls desmin intermediate filament architecture and mitochondrial dynamics in human and mouse skeletal muscle

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17661

determination method or standard

8 April 2019

A proteome-scale map of the human interactome network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17661

determination method or standard

8 April 2019

Cytoskeletal scaffolding proteins interact with Lynch-Syndrome associated mismatch repair protein MLH1

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17661

determination method or standard

8 April 2019

Pooled-matrix protein interaction screens using Barcode Fusion Genetics

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17661

determination method or standard

8 April 2019

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17661

determination method or standard

structural constituent of cytoskeleton

determination method or standard

1 reference

8 April 2019

A dysfunctional desmin mutation in a patient with severe generalized myopathy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17661

determination method or standard

identical protein binding

determination method or standard

1 reference

8 April 2019

Myotubularin controls desmin intermediate filament architecture and mitochondrial dynamics in human and mouse skeletal muscle

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17661

determination method or standard

structural molecule activity

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17661

determination method or standard

cytoskeletal protein binding

determination method or standard

1 reference

8 April 2019

Myopalladin, a novel 145-kilodalton sarcomeric protein with multiple roles in Z-disc and I-band protein assemblies

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17661

determination method or standard

intercalated disc

determination method or standard

2 references

8 April 2019

The novel desmin mutant p.A120D impairs filament formation, prevents intercalated disk localization, and causes sudden cardiac death

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17661

determination method or standard

8 April 2019

Functional characterization of the novel DES mutation p.L136P associated with dilated cardiomyopathy reveals a dominant filament assembly defect

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17661

determination method or standard

determination method or standard

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17661

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17661

determination method or standard

8 April 2019

The toxic effect of R350P mutant desmin in striated muscle of man and mouse

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17661

determination method or standard

intermediate filament cytoskeleton

determination method or standard

1 reference

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17661

determination method or standard

contractile fiber

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17661

determination method or standard

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17661

determination method or standard

neuromuscular junction

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17661

determination method or standard

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17661

determination method or standard

determination method or standard

5 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17661

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17661

determination method or standard

8 April 2019

The novel desmin mutant p.A120D impairs filament formation, prevents intercalated disk localization, and causes sudden cardiac death

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17661

determination method or standard

8 April 2019

Functional characterization of the novel DES mutation p.L136P associated with dilated cardiomyopathy reveals a dominant filament assembly defect

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17661

determination method or standard

8 April 2019

Spatial and temporal expression of the β1D integrin during mouse development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17661

determination method or standard

plasma membrane

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17661

determination method or standard

fascia adherens

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17661

determination method or standard

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17661

determination method or standard

extracellular exosome

determination method or standard

1 reference

31 October 2017

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17661&geneProductId=UniProtKB:P17661

determination method or standard

intermediate filament

determination method or standard

4 references

8 April 2019

A dysfunctional desmin mutation in a patient with severe generalized myopathy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17661

determination method or standard

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17661

determination method or standard

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17661

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17661

determination method or standard

cell-cell junction

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17661

determination method or standard

cardiac myofibril

determination method or standard

1 reference

8 April 2019

A novel phosphorylation site, Serine 199, in the C-terminus of cardiac troponin I regulates calcium sensitivity and susceptibility to calpain-induced proteolysis

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17661

determination method or standard

determination method or standard

extracellular exosome

determination method or standard

1 reference

8 April 2019

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17661

determination method or standard

biological process

muscle contraction

determination method or standard

1 reference

8 April 2019

Missense mutations in desmin associated with familial cardiac and skeletal myopathy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17661

determination method or standard

intermediate filament organization

determination method or standard

2 references

8 April 2019

The novel desmin mutant p.A120D impairs filament formation, prevents intercalated disk localization, and causes sudden cardiac death

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17661

determination method or standard

8 April 2019

Functional characterization of the novel DES mutation p.L136P associated with dilated cardiomyopathy reveals a dominant filament assembly defect

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17661

determination method or standard

cytoskeleton organization

determination method or standard

1 reference

8 April 2019

A dysfunctional desmin mutation in a patient with severe generalized myopathy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17661

determination method or standard

muscle filament sliding

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17661

determination method or standard

regulation of heart contraction

determination method or standard

1 reference

8 April 2019

Missense mutations in desmin associated with familial cardiac and skeletal myopathy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17661

determination method or standard

Gene Atlas image

PBB GE DES 202222 s at fs.png
732 × 530; 11 KB

0 references

http://purl.uniprot.org/uniprot/P17661

1 reference

Identifiers.org

Intermediate filament protein, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P17661

Intermediate filament head, DNA-binding domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P17661

Intermediate filament, rod domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P17661

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000363071

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000363071

1 reference

Freebase Data Dumps

publication date

28 October 2013

Microsoft Academic ID (discontinued)

0 references

0 references

1 reference

26 January 2022

https://docs.openalex.org/download-snapshot/snapshot-data-format

Sitelinks

Wikipedia(13 entries)

bswiki CMD1F
cswiki Desmin
dewiki Desmin
enwiki Desmin
eswiki Desmina
frwiki Desmine
glwiki Desmina
idwiki Desmin
itwiki Desmina
jawiki デスミン
kowiki 데스민
ruwiki Десмин
ukwiki Десмін (білок)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q425146&oldid=2301784023"