Glucocorticoids induce osteocyte apoptosis by blocking focal adhesion kinase-mediated survival. Evidence for inside-out signaling leading to anoikis (Q42514385)

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English	Glucocorticoids induce osteocyte apoptosis by blocking focal adhesion kinase-mediated survival. Evidence for inside-out signaling leading to anoikis	scientific article

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scholarly article

1 reference

Europe PubMed Central

1 November 2017

Glucocorticoids induce osteocyte apoptosis by blocking focal adhesion kinase-mediated survival. Evidence for inside-out signaling leading to anoikis (English)

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Europe PubMed Central

1 November 2017

apoptotic process

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Teresita M. Bellido

3

object named as

Teresita Bellido

1 reference

Europe PubMed Central

1 November 2017

author name string

Lillian I Plotkin

1

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Europe PubMed Central

1 November 2017

Stavros C Manolagas

2

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Europe PubMed Central

1 November 2017

language of work or name

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publication date

20 June 2007

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Europe PubMed Central

1 November 2017

number of pages

11

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based on heuristic

inferred from page(s)

Journal of Biological Chemistry

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Europe PubMed Central

1 November 2017

282

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Europe PubMed Central

1 November 2017

24120-24130

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Europe PubMed Central

1 November 2017

33

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Europe PubMed Central

1 November 2017

Mechanisms of glucocorticoid receptor action in noninflammatory and inflammatory cells

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21 January 2018

Antiinflammatory action of glucocorticoids--new mechanisms for old drugs

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21 January 2018

Cushing's syndrome

1 reference

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21 January 2018

The pathogenesis, epidemiology and management of glucocorticoid-induced osteoporosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611435200

21 January 2018

Glucocorticoid-induced osteoporosis: an update

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611435200

21 January 2018

Inhibition of osteoblastogenesis and promotion of apoptosis of osteoblasts and osteocytes by glucocorticoids. Potential mechanisms of their deleterious effects on bone

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https://api.crossref.org/works/10.1074%2FJBC.M611435200

21 January 2018

Glucocorticoids act directly on osteoblasts and osteocytes to induce their apoptosis and reduce bone formation and strength

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https://api.crossref.org/works/10.1074%2FJBC.M611435200

21 January 2018

Increased bone formation by prevention of osteoblast apoptosis with parathyroid hormone

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https://api.crossref.org/works/10.1074%2FJBC.M611435200

21 January 2018

Prevention of osteocyte and osteoblast apoptosis by bisphosphonates and calcitonin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611435200

21 January 2018

Glucocorticoid-induced apoptosis in human eosinophils: mechanisms of action

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611435200

21 January 2018

Nontranscriptional actions of the glucocorticoid receptor.

1 reference

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21 January 2018

Adaptor proteins Grb2 and Crk couple Pyk2 with activation of specific mitogen-activated protein kinase cascades

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611435200

21 January 2018

Protection from natural killer cell-mediated lysis by HLA-G expression on target cells

1 reference

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21 January 2018

RAFTK/PYK2-dependent and -independent apoptosis in multiple myeloma cells.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611435200

21 January 2018

Induction of apoptosis after expression of PYK2, a tyrosine kinase structurally related to focal adhesion kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611435200

21 January 2018

Cloning and characterization of cell adhesion kinase beta, a novel protein-tyrosine kinase of the focal adhesion kinase subfamily

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611435200

21 January 2018

RAFTK/Pyk2-mediated cellular signalling

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https://api.crossref.org/works/10.1074%2FJBC.M611435200

21 January 2018

Mechanical stimulation prevents osteocyte apoptosis: requirement of integrins, Src kinases, and ERKs

1 reference

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21 January 2018

The tyrosine kinase PYK-2/RAFTK regulates natural killer (NK) cell cytotoxic response, and is translocated and activated upon specific target cell recognition and killing

1 reference

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21 January 2018

Extracellular signal-regulated protein kinase/Jun kinase cross-talk underlies vascular endothelial cell growth factor-induced endothelial cell proliferation

1 reference

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21 January 2018

Natriuretic peptides suppress vascular endothelial cell growth factor signaling to angiogenesis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611435200

21 January 2018

Transduction of cell survival signals by connexin-43 hemichannels

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611435200

21 January 2018

Establishment of an osteocyte-like cell line, MLO-Y4.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611435200

21 January 2018

Dissociation of the pro-apoptotic effects of bisphosphonates on osteoclasts from their anti-apoptotic effects on osteoblasts/osteocytes with novel analogs

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611435200

21 January 2018

Wnt proteins prevent apoptosis of both uncommitted osteoblast progenitors and differentiated osteoblasts by beta-catenin-dependent and -independent signaling cascades involving Src/ERK and phosphatidylinositol 3-kinase/AKT.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611435200

21 January 2018

Prevention of glucocorticoid-induced apoptosis in osteocytes and osteoblasts by calbindin-D28k.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611435200

21 January 2018

Fas/CD95 is associated with glucocorticoid-induced osteocyte apoptosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611435200

21 January 2018

Glucocorticoid antagonists

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611435200

21 January 2018

Focal adhesion kinase signaling activities and their implications in the control of cell survival and motility

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611435200

21 January 2018

Activation of a novel calcium-dependent protein-tyrosine kinase. Correlation with c-Jun N-terminal kinase but not mitogen-activated protein kinase activation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611435200

21 January 2018

PYK2 regulates SERCA2 gene expression in neonatal rat ventricular myocytes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611435200

21 January 2018

Nongenotropic, anti-apoptotic signaling of 1alpha,25(OH)2-vitamin D3 and analogs through the ligand binding domain of the vitamin D receptor in osteoblasts and osteocytes. Mediation by Src, phosphatidylinositol 3-, and JNK kinases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611435200

21 January 2018

Integrin signaling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611435200

21 January 2018

Integrins and anoikis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611435200

21 January 2018

Integrin regulation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611435200

21 January 2018

Integrins: bidirectional, allosteric signaling machines

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611435200

21 January 2018

Matrix metalloproteinase-dependent activation of latent transforming growth factor-beta controls the conversion of osteoblasts into osteocytes by blocking osteoblast apoptosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611435200

21 January 2018

Matrix metalloproteinases (MMPs) safeguard osteoblasts from apoptosis during transdifferentiation into osteocytes: MT1-MMP maintains osteocyte viability

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611435200

21 January 2018

Osteocyte and osteoblast apoptosis and excessive bone deposition accompany failure of collagenase cleavage of collagen

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611435200

21 January 2018

A crucial role for matrix metalloproteinase 2 in osteocytic canalicular formation and bone metabolism

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611435200

21 January 2018

Ultrastructure of the osteocyte process and its pericellular matrix.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611435200

21 January 2018

Osteocyte apoptosis is induced by weightlessness in mice and precedes osteoclast recruitment and bone loss.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611435200

21 January 2018

Control of adhesion-dependent cell survival by focal adhesion kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611435200

21 January 2018

Reduction in transforming growth factor beta receptor I expression and transcription factor CBFa1 on bone cells by glucocorticoid.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611435200

21 January 2018

Post-transcriptional and nongenomic effects of glucocorticoids.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611435200

21 January 2018

Role of caspases in dexamethasone-induced apoptosis and activation of c-Jun NH2-terminal kinase and p38 mitogen-activated protein kinase in human eosinophils

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611435200

21 January 2018

p38 Mitogen-activated protein kinase (MAPK) is a key mediator in glucocorticoid-induced apoptosis of lymphoid cells: correlation between p38 MAPK activation and site-specific phosphorylation of the human glucocorticoid receptor at serine 211.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611435200

21 January 2018

Glucocorticoids induce rapid up-regulation of mitogen-activated protein kinase phosphatase-1 and dephosphorylation of extracellular signal-regulated kinase and impair proliferation in human and mouse osteoblast cell lines

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611435200

21 January 2018

Angiotensin II initiates tyrosine kinase Pyk2-dependent signalings leading to activation of Rac1-mediated c-Jun NH2-terminal kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611435200

21 January 2018

Tyrosine phosphorylation of the related adhesion focal tyrosine kinase in megakaryocytes upon stem cell factor and phorbol myristate acetate stimulation and its association with paxillin

1 reference

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21 January 2018

Glucocorticoid excess induces superoxide production in vascular endothelial cells and elicits vascular endothelial dysfunction

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611435200

21 January 2018

Fluid shear stress activates proline-rich tyrosine kinase via reactive oxygen species-dependent pathway

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611435200

21 January 2018

Rho GTPases: biochemistry and biology

1 reference

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21 January 2018

Reactive oxygen species as mediators of calcium signaling by angiotensin II: implications in vascular physiology and pathophysiology

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611435200

21 January 2018

Signal-crosstalk between Rho/ROCK and c-Jun NH2-terminal kinase mediates migration of vascular smooth muscle cells stimulated by angiotensin II.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611435200

21 January 2018

Glucocorticoids suppress bone formation via the osteoclast

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611435200

21 January 2018

PYK2 autophosphorylation, but not kinase activity, is necessary for adhesion-induced association with c-Src, osteoclast spreading, and bone resorption

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611435200

21 January 2018

Cbl associates with Pyk2 and Src to regulate Src kinase activity, alpha(v)beta(3) integrin-mediated signaling, cell adhesion, and osteoclast motility

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611435200

21 January 2018

Age and bone mass as predictors of fracture in a prospective study

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611435200

21 January 2018

Pyk2 regulates multiple signaling events crucial for macrophage morphology and migration

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611435200

21 January 2018

Proline-rich tyrosine kinase 2 regulates osteoprogenitor cells and bone formation, and offers an anabolic treatment approach for osteoporosis

1 reference

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21 January 2018

Identifiers

10.1074/JBC.M611435200

1 reference

Europe PubMed Central

1 November 2017

1 reference

Europe PubMed Central

1 November 2017

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