A conserved Asn in transmembrane helix 7 is an on/off switch in the activation of the thyrotropin receptor (Q42503124)

1 November 2017

A conserved Asn in transmembrane helix 7 is an on/off switch in the activation of the thyrotropin receptor (English)

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1 November 2017

transmembrane protein

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author

Leonardo Pardo

7

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1 November 2017

4

Wodak SJ

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1 November 2017

Govaerts C

1

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1 November 2017

Lefort A

2

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1 November 2017

Costagliola S

3

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1 November 2017

Ballesteros JA

5

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1 November 2017

Van Sande J

6

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1 November 2017

Vassart G

8

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1 November 2017

language of work or name

English

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publication date

18 April 2001

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Journal of Biological Chemistry

1 November 2017

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1 November 2017

276

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1 November 2017

22991-22999

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1 November 2017

25

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Production of bioactive amino-terminal domain of the thyrotropin receptor via insertion in the plasma membrane by a glycosylphosphatidylinositol anchor

1 November 2017

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https://api.crossref.org/works/10.1074%2FJBC.M102244200

Modeling of the three-dimensional structure of proteins with the typical leucine-rich repeats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M102244200

Proteins with leucine-rich repeats

21 January 2018

1 reference

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Molecular cloning, genomic organization, and developmental regulation of a novel receptor from Drosophila melanogaster structurally related to members of the thyroid-stimulating hormone, follicle-stimulating hormone, luteinizing hormone/choriogonado

21 January 2018

1 reference

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Molecular cloning of a novel, putative G protein-coupled receptor from sea anemones structurally related to members of the FSH, TSH, LH/CG receptor family from mammals

21 January 2018

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Molecular cloning, genomic organization, developmental regulation, and a knock-out mutant of a novel leu-rich repeats-containing G protein-coupled receptor (DLGR-2) from Drosophila melanogaster

21 January 2018

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2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans

21 January 2018

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Characterization of two LGR genes homologous to gonadotropin and thyrotropin receptors with extracellular leucine-rich repeats and a G protein-coupled, seven-transmembrane region

21 January 2018

1 reference

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The Three Subfamilies of Leucine-Rich Repeat-Containing G Protein-Coupled Receptors (LGR): Identification of LGR6 and LGR7 and the Signaling Mechanism for LGR7

21 January 2018

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Somatic mutations in the thyrotropin receptor gene cause hyperfunctioning thyroid adenomas

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M102244200

Germline mutations in the thyrotropin receptor gene cause non-autoimmune autosomal dominant hyperthyroidism

21 January 2018

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Mutations of gonadotropins and gonadotropin receptors: elucidating the physiology and pathophysiology of pituitary-gonadal function.

21 January 2018

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Transmembrane regions V and VI of the human luteinizing hormone receptor are required for constitutive activation by a mutation in the third intracellular loop

21 January 2018

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An activating mutation of the follicle-stimulating hormone receptor autonomously sustains spermatogenesis in a hypophysectomized man.

21 January 2018

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Crystal structure of rhodopsin: A G protein-coupled receptor

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A constitutively activating mutation of the luteinizing hormone receptor in familial male precocious puberty

21 January 2018

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A model of the lutropin/choriogonadotropin receptor: insights into the structural and functional effects of constitutively activating mutations.

21 January 2018

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Analysis of covariation in an SH3 domain sequence alignment: applications in tertiary contact prediction and the design of compensating hydrophobic core substitutions

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A Second Generation Force Field for the Simulation of Proteins, Nucleic Acids, and Organic Molecules

21 January 2018

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Cloning, sequencing and expression of the human thyrotropin (TSH) receptor: evidence for binding of autoantibodies

21 January 2018

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Diversity and prevalence of somatic mutations in the thyrotropin receptor and Gs alpha genes as a cause of toxic thyroid adenomas

21 January 2018

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Somatic and germline mutations of the TSH receptor gene in thyroid diseases.

21 January 2018

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GPCRDB: an information system for G protein-coupled receptors

21 January 2018

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In Chinese hamster ovary K1 cells dog and human thyrotropin receptors activate both the cyclic AMP and the phosphatidylinositol 4,5-bisphosphate cascades in the presence of thyrotropin and the cyclic AMP cascade in its absence

21 January 2018

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Functional characteristics of three new germline mutations of the thyrotropin receptor gene causing autosomal dominant toxic thyroid hyperplasia

21 January 2018

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The role of Asp578 in maintaining the inactive conformation of the human lutropin/choriogonadotropin receptor

21 January 2018

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Conserved polar residues in the transmembrane domain of the human tachykinin NK2 receptor: functional roles and structural implications

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C5a receptor activation. Genetic identification of critical residues in four transmembrane helices

21 January 2018

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Identification of a ligand-dependent switch within a muscarinic receptor

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Molecular determinants of human red/green color discrimination

21 January 2018

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Fourier transform infrared difference spectroscopy of rhodopsin mutants: light activation of rhodopsin causes hydrogen-bonding change in residue aspartic acid-83 during meta II formation.

21 January 2018

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Uncovering molecular mechanisms involved in activation of G protein-coupled receptors

21 January 2018

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Rhodopsin-family receptors associate with small G proteins to activate phospholipase D.

21 January 2018

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The activation process of the alpha1B-adrenergic receptor: potential role of protonation and hydrophobicity of a highly conserved aspartate

21 January 2018

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Agonists induce conformational changes in transmembrane domains III and VI of the beta2 adrenoceptor

21 January 2018

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The effect of pH on beta(2) adrenoceptor function. Evidence for protonation-dependent activation.

21 January 2018

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Protonation states of membrane-embedded carboxylic acid groups in rhodopsin and metarhodopsin II: a Fourier-transform infrared spectroscopy study of site-directed mutants.

21 January 2018

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Somatic mutations causing constitutive activity of the thyrotropin receptor are the major cause of hyperfunctioning thyroid adenomas: identification of additional mutations activating both the cyclic adenosine 3',5'-monophosphate and inositol phosph

21 January 2018

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Functional Microdomains in G-protein-coupled Receptors

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M102244200

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1 November 2017

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