Eight years of clinical improvement in MPTP-lesioned primates after gene therapy with AAV2-hAADC. (Q42502571)

1 November 2017

Eight years of clinical improvement in MPTP-lesioned primates after gene therapy with AAV2-hAADC. (English)

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1 November 2017

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4

John Bringas

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Philip Pivirotto

3

object named as

Philip Pivirotto

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Piotr Hadaczek

1

object named as

Piotr Hadaczek

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1 November 2017

Jamie L Eberling

2

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1 November 2017

Philip Pivirotto

3

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1 November 2017

John Bringas

4

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1 November 2017

John Forsayeth

5

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1 November 2017

Krystof S Bankiewicz

6

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1 November 2017

language of work or name

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8 June 2010

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1 November 2017

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18

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8

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1 November 2017

1458-1461

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Safety and tolerability of putaminal AADC gene therapy for Parkinson disease

1 November 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2927057

Safety evaluation of AAV2-GDNF gene transfer into the dopaminergic nigrostriatal pathway in aged and parkinsonian rhesus monkeys

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2927057

Expression, bioactivity, and safety 1 year after adeno-associated viral vector type 2-mediated delivery of neurturin to the monkey nigrostriatal system support cere-120 for Parkinson's disease

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2927057

Real-time MR imaging of adeno-associated viral vector delivery to the primate brain

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2927057

Biodistribution of adeno-associated virus type-2 in nonhuman primates after convection-enhanced delivery to brain

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2927057

Results from a phase I safety trial of hAADC gene therapy for Parkinson disease

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2927057

Current status of gene therapy trials for Parkinson's disease

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2927057

Gene therapy clinical trials worldwide to 2007--an update.

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2927057

A dose-ranging study of AAV-hAADC therapy in Parkinsonian monkeys

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2927057

Focal striatal dopamine may potentiate dyskinesias in parkinsonian monkeys

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2927057

Striatal delivery of rAAV-hAADC to rats with preexisting immunity to AAV.

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2927057

Convection-enhanced delivery of AAV vector in parkinsonian monkeys; in vivo detection of gene expression and restoration of dopaminergic function using pro-drug approach

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2927057

Transduction of nonhuman primate brain with adeno-associated virus serotype 1: vector trafficking and immune response

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2927057

Safety and tolerability of intraputaminal delivery of CERE-120 (adeno-associated virus serotype 2-neurturin) to patients with idiopathic Parkinson's disease: an open-label, phase I trial

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2927057

Long-term clinical improvement in MPTP-lesioned primates after gene therapy with AAV-hAADC.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2927057

16 August 2018

Identifiers

DOI

10.1038/MT.2010.106

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1 November 2017

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1 November 2017

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