Diverse biochemical properties of Shp2 mutants. Implications for disease phenotypes (Q42480603)

1 November 2017

title

Diverse biochemical properties of Shp2 mutants. Implications for disease phenotypes (English)

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1 November 2017

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Heike Keilhack

1

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1 November 2017

Frank S David

2

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1 November 2017

Malcolm McGregor

3

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1 November 2017

Lewis C Cantley

4

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1 November 2017

Benjamin G Neel

5

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1 November 2017

publication date

29 June 2005

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Journal of Biological Chemistry

1 November 2017

language of work or name

English

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published in

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1 November 2017

volume

280

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1 November 2017

issue

35

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1 November 2017

page(s)

30984-30993

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The 'Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling

1 November 2017

cites work

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Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome

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Somatic mutations in PTPN11 in juvenile myelomonocytic leukemia, myelodysplastic syndromes and acute myeloid leukemia

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SHP-2 and myeloid malignancies

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Tyrosyl phosphorylation of Shp2 is required for normal ERK activation in response to some, but not all, growth factors

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Crystal Structure of the Tyrosine Phosphatase SHP-2

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Spatial constraints on the recognition of phosphoproteins by the tandem SH2 domains of the phosphatase SH-PTP2

21 January 2018

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Activated mutants of SHP-2 preferentially induce elongation of Xenopus animal caps

21 January 2018

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Noonan syndrome-associated SHP2/PTPN11 mutants cause EGF-dependent prolonged GAB1 binding and sustained ERK2/MAPK1 activation

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Spectrum of mutations in PTPN11 and genotype-phenotype correlation in 96 patients with Noonan syndrome and five patients with cardio-facio-cutaneous syndrome

21 January 2018

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Phosphotyrosine 1173 Mediates Binding of the Protein-tyrosine Phosphatase SHP-1 to the Epidermal Growth Factor Receptor and Attenuation of Receptor Signaling

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BRCT Repeats As Phosphopeptide-Binding Modules Involved in Protein Targeting

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A widely expressed human protein-tyrosine phosphatase containing src homology 2 domains

21 January 2018

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Crystal structures of peptide complexes of the amino-terminal SH2 domain of the Syp tyrosine phosphatase

21 January 2018

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Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons

21 January 2018

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Attenuation of adhesion-dependent signaling and cell spreading in transformed fibroblasts lacking protein tyrosine phosphatase-1B.

21 January 2018

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Targeted disruption of the tyrosine phosphatase PTPalpha leads to constitutive downregulation of the kinases Src and Fyn.

21 January 2018

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Cell transformation and activation of pp60c-src by overexpression of a protein tyrosine phosphatase

21 January 2018

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Visualization of the Cysteinyl-phosphate Intermediate of a Protein-tyrosine Phosphatase by X-ray Crystallography

21 January 2018

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Molecular basis for the dephosphorylation of the activation segment of the insulin receptor by protein tyrosine phosphatase 1B

21 January 2018

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Functional analysis of PTPN11/SHP-2 mutants identified in Noonan syndrome and childhood leukemia

21 January 2018

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21 January 2018

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The 64-kDa protein that associates with the platelet-derived growth factor receptor beta subunit via Tyr-1009 is the SH2-containing phosphotyrosine phosphatase Syp

21 January 2018

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The "Gab" in signal transduction.

21 January 2018

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IRS proteins and the common path to diabetes

21 January 2018

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Catalytic specificity of protein-tyrosine kinases is critical for selective signalling

21 January 2018

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Oncogenic mutation in the Kit receptor tyrosine kinase alters substrate specificity and induces degradation of the protein tyrosine phosphatase SHP-1

21 January 2018

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Correlation between PTPN11 gene mutations and congenital heart defects in Noonan and LEOPARD syndromes.

21 January 2018

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Prognostic, therapeutic, and mechanistic implications of a mouse model of leukemia evoked by Shp2 (PTPN11) mutations.

21 January 2018

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Functional analysis of leukemia-associated PTPN11 mutations in primary hematopoietic cells

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M504699200

1 reference

release_4v355kkdgngdvb5b72azpio4wu

1 November 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/4v355kkdgngdvb5b72azpio4wu

mapped directly with Wikidata item

24 November 2022

based on heuristic

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