Diverse biochemical properties of Shp2 mutants. Implications for disease phenotypes (Q42480603)

1 November 2017

Diverse biochemical properties of Shp2 mutants. Implications for disease phenotypes (English)

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1 November 2017

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Heike Keilhack

1

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1 November 2017

Frank S David

2

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1 November 2017

Malcolm McGregor

3

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1 November 2017

Lewis C Cantley

4

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1 November 2017

Benjamin G Neel

5

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1 November 2017

language of work or name

English

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publication date

29 June 2005

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Journal of Biological Chemistry

1 November 2017

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1 November 2017

280

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1 November 2017

30984-30993

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1 November 2017

35

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The 'Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling

1 November 2017

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https://api.crossref.org/works/10.1074%2FJBC.M504699200

Mutations in PTPN11 implicate the SHP-2 phosphatase in leukemogenesis

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M504699200

Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M504699200

Somatic mutations in PTPN11 in juvenile myelomonocytic leukemia, myelodysplastic syndromes and acute myeloid leukemia

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M504699200

SHP-2 and myeloid malignancies

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M504699200

PTPN11 (Protein-Tyrosine Phosphatase, Nonreceptor-Type 11) Mutations in Seven Japanese Patients with Noonan Syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504699200

PTPN11 mutations in Noonan syndrome: molecular spectrum, genotype-phenotype correlation, and phenotypic heterogeneity

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M504699200

Protein-tyrosine phosphatase, nonreceptor type 11 mutation analysis and clinical assessment in 45 patients with Noonan syndrome.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M504699200

Congenital heart diseases in children with Noonan syndrome: An expanded cardiac spectrum with high prevalence of atrioventricular canal

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504699200

Noonan's syndrome in association with acute leukemia.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M504699200

Somatic PTPN11 mutation with a heterogeneous clonal origin in children with juvenile myelomonocytic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504699200

Genetic evidence for lineage-related and differentiation stage-related contribution of somatic PTPN11 mutations to leukemogenesis in childhood acute leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504699200

PTPN11 mutations in pediatric patients with acute myeloid leukemia: results from the Children's Cancer Group

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504699200

Activating mutations of the noonan syndrome-associated SHP2/PTPN11 gene in human solid tumors and adult acute myelogenous leukemia

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M504699200

Tyrosyl phosphorylation of Shp2 is required for normal ERK activation in response to some, but not all, growth factors

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M504699200

Crystal structure of the tyrosine phosphatase SHP-2

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M504699200

Spatial constraints on the recognition of phosphoproteins by the tandem SH2 domains of the phosphatase SH-PTP2

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M504699200

Activated mutants of SHP-2 preferentially induce elongation of Xenopus animal caps

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M504699200

Noonan syndrome-associated SHP2/PTPN11 mutants cause EGF-dependent prolonged GAB1 binding and sustained ERK2/MAPK1 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504699200

PTPN11 mutations in Noonan syndrome type I: detection of recurrent mutations in exons 3 and 13.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504699200

Spectrum of mutations in PTPN11 and genotype-phenotype correlation in 96 patients with Noonan syndrome and five patients with cardio-facio-cutaneous syndrome

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M504699200

Isolation of a src homology 2-containing tyrosine phosphatase

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M504699200

Phosphotyrosine 1173 mediates binding of the protein-tyrosine phosphatase SHP-1 to the epidermal growth factor receptor and attenuation of receptor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504699200

BRCT Repeats As Phosphopeptide-Binding Modules Involved in Protein Targeting

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504699200

A widely expressed human protein-tyrosine phosphatase containing src homology 2 domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504699200

Crystal structures of peptide complexes of the amino-terminal SH2 domain of the Syp tyrosine phosphatase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504699200

Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M504699200

Attenuation of adhesion-dependent signaling and cell spreading in transformed fibroblasts lacking protein tyrosine phosphatase-1B.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M504699200

Targeted disruption of the tyrosine phosphatase PTPalpha leads to constitutive downregulation of the kinases Src and Fyn.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504699200

Cell transformation and activation of pp60c-src by overexpression of a protein tyrosine phosphatase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504699200

Visualization of the cysteinyl-phosphate intermediate of a protein-tyrosine phosphatase by x-ray crystallography

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504699200

Molecular basis for the dephosphorylation of the activation segment of the insulin receptor by protein tyrosine phosphatase 1B

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504699200

Functional analysis of PTPN11/SHP-2 mutants identified in Noonan syndrome and childhood leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504699200

Acquiring signalling specificity from the cytokine receptor gp130.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504699200

The 64-kDa protein that associates with the platelet-derived growth factor receptor beta subunit via Tyr-1009 is the SH2-containing phosphotyrosine phosphatase Syp

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504699200

The "Gab" in signal transduction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504699200

IRS proteins and the common path to diabetes

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M504699200

Catalytic specificity of protein-tyrosine kinases is critical for selective signalling

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M504699200

Oncogenic mutation in the Kit receptor tyrosine kinase alters substrate specificity and induces degradation of the protein tyrosine phosphatase SHP-1

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M504699200

Correlation between PTPN11 gene mutations and congenital heart defects in Noonan and LEOPARD syndromes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504699200

Prognostic, therapeutic, and mechanistic implications of a mouse model of leukemia evoked by Shp2 (PTPN11) mutations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504699200

Functional analysis of leukemia-associated PTPN11 mutations in primary hematopoietic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504699200

21 January 2018

Identifiers

DOI

10.1074/JBC.M504699200

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release_4v355kkdgngdvb5b72azpio4wu

1 November 2017

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Fatcat

https://api.fatcat.wiki/v0/release/4v355kkdgngdvb5b72azpio4wu

mapped directly with Wikidata item

24 November 2022

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