Downmodulation of ERK protein kinase activity inhibits VEGF secretion by human myeloma cells and myeloma-induced angiogenesis. (Q42455980)

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17 November 2019

title

Downmodulation of ERK protein kinase activity inhibits VEGF secretion by human myeloma cells and myeloma-induced angiogenesis (English)

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17 November 2019

1

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17 November 2019

Simona Colla

4

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17 November 2019

Paolo Lunghi

2

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17 November 2019

author name string

F Morandi

3

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17 November 2019

S Bonomini

5

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17 November 2019

M Hojden

6

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17 November 2019

V Rizzoli

7

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17 November 2019

A Bonati

8

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17 November 2019

publication date

1 March 2004

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17 November 2019

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17 November 2019

volume

18

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17 November 2019

page(s)

628-635

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17 November 2019

issue

3

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https://scigraph.springernature.com/pub.10.1038/sj.leu.2403269

17 November 2019

exact match

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cites work

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The roles of signaling by the p42/p44 mitogen-activated protein (MAP) kinase pathway; a potential route to radio- and chemo-sensitization of tumor cells resulting in the induction of apoptosis and loss of clonogenicity

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Molecular mechanisms of novel therapeutic approaches for multiple myeloma

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Biologic sequelae of interleukin-6 induced PI3-K/Akt signaling in multiple myeloma

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Expression of vascular endothelial growth factor and its receptors in multiple myeloma and other hematopoietic malignancies

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A synthetic inhibitor of the mitogen-activated protein kinase cascade

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PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo

21 January 2018

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Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo

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Development of anticancer drugs targeting the MAP kinase pathway

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Pharmacological inhibitors of MAPK pathways.

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Increased bone marrow microvessel density in newly diagnosed multiple myeloma carries a poor prognosis

21 January 2018

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Proliferation of IL-6-independent multiple myeloma does not require the activity of extracellular signal-regulated kinases (ERK1/2).

21 January 2018

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Combined treatment with the checkpoint abrogator UCN-01 and MEK1/2 inhibitors potently induces apoptosis in drug-sensitive and -resistant myeloma cells through an IL-6-independent mechanism

21 January 2018

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Cell-cycle arrest by PD184352 requires inhibition of extracellular signal-regulated kinases (ERK) 1/2 but not ERK5/BMK1.

21 January 2018

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Effects of MAP kinase cascade inhibitors on the MKK5/ERK5 pathway

21 January 2018

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Targeting p38 MAPK inhibits multiple myeloma cell growth in the bone marrow milieu

21 January 2018

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Requirement for the PI3K/Akt pathway in MEK1-mediated growth and prevention of apoptosis: identification of an Achilles heel in leukemia.

21 January 2018

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Effects of the RAF/MEK/ERK and PI3K/AKT signal transduction pathways on the abrogation of cytokine-dependence and prevention of apoptosis in hematopoietic cells.

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Constitutive activation of mitogen-activated protein kinase pathway in acute leukemia cells

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7 January 2021

Downmodulation of ERK activity inhibits the proliferation and induces the apoptosis of primary acute myelogenous leukemia blasts

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7 January 2021

The MEK inhibitor, PD98059, reduces survival but does not block acute myeloid leukemia blast maturation in vitro

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7 January 2021

Vascular endothelial growth factor triggers signaling cascades mediating multiple myeloma cell growth and migration

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7 January 2021

MEK wars, a new front in the battle against cancer

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Proangiogenic properties of human myeloma cells: production of angiopoietin-1 and its potential relationship to myeloma-induced angiogenesis

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7 January 2021

Identifiers

DOI

10.1038/SJ.LEU.2403269

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14737074%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

17 November 2019

1032115202

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Fatcat ID

release_z4xsgdfikvhixma3uxcf4pizii

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/z4xsgdfikvhixma3uxcf4pizii

24 November 2022

mapped directly with Wikidata item

1 reference