Deletions in the third intracellular loop of the thyrotropin receptor. A new mechanism for constitutive activation (Q42453064)

31 October 2017

Deletions in the third intracellular loop of the thyrotropin receptor. A new mechanism for constitutive activation (English)

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31 October 2017

Wonerow P

1

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31 October 2017

Schöneberg T

2

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31 October 2017

Schultz G

3

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31 October 2017

Gudermann T

4

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31 October 2017

Paschke R

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31 October 2017

language of work or name

English

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publication date

1 April 1998

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Journal of Biological Chemistry

31 October 2017

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31 October 2017

273

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31 October 2017

14

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31 October 2017

7900-7905

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The Thyrotropin Receptor and the Regulation of Thyrocyte Function and Growth*

31 October 2017

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https://api.crossref.org/works/10.1074%2FJBC.273.14.7900

Receptors and G proteins as primary components of transmembrane signal transduction. Part 1. G-protein-coupled receptors: structure and function.

21 January 2018

1 reference

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Rhodopsin activation blocked by metal-ion-binding sites linking transmembrane helices C and F.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.14.7900

Mutation of Asn111 in the third transmembrane domain of the AT1A angiotensin II receptor induces its constitutive activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.14.7900

Alanine exchanges of polar amino acids in the transmembrane domains of a platelet-activating factor receptor generate both constitutively active and inactive mutants

21 January 2018

1 reference

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The conformational change responsible for AT1 receptor activation is dependent upon two juxtaposed asparagine residues on transmembrane helices III and VII.

21 January 2018

1 reference

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Molecular Architecture of G Protein-Coupled Receptors.

21 January 2018

1 reference

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Germline mutations in the thyrotropin receptor gene cause non-autoimmune autosomal dominant hyperthyroidism

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.14.7900

The thyrotropin receptor in thyroid diseases.

21 January 2018

1 reference

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Constitutive activation of cyclic AMP but not phosphatidylinositol signaling caused by four mutations in the 6th transmembrane helix of the human thyrotropin receptor

21 January 2018

1 reference

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A neomutation of the thyroid-stimulating hormone receptor in a severe neonatal hyperthyroidism

21 January 2018

1 reference

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Somatic and germline mutations of the TSH receptor gene in thyroid diseases.

21 January 2018

1 reference

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Somatic mutations causing constitutive activity of the thyrotropin receptor are the major cause of hyperfunctioning thyroid adenomas: identification of additional mutations activating both the cyclic adenosine 3',5'-monophosphate and inositol phosph

21 January 2018

1 reference

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Functional characteristics of three new germline mutations of the thyrotropin receptor gene causing autosomal dominant toxic thyroid hyperplasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.14.7900

Model systems for the study of seven-transmembrane-segment receptors

21 January 2018

1 reference

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Signal Transduction by the Human Thyrotropin Receptor: Studies on the Role of Individual Amino Acid Residues in the Carboxyl Terminal Region of the Third Cytoplasmic Loop

21 January 2018

1 reference

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The third cytoplasmic domain of the GLP-1[7-36 amide] receptor is required for coupling to the adenylyl cyclase system

21 January 2018

1 reference

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Cloning, sequencing and expression of the human thyrotropin (TSH) receptor: evidence for binding of autoantibodies

21 January 2018

1 reference

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Rapid accumulation of inositol trisphosphate reveals that agonists hydrolyse polyphosphoinositides instead of phosphatidylinositol

21 January 2018

1 reference

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Differential effects of NaCl concentration on the constitutive activity of the thyrotropin and the luteinizing hormone/chorionic gonadotropin receptors

21 January 2018

1 reference

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Rarity of oncogenic mutations in the thyrotropin receptor of autonomously functioning thyroid nodules in Japan

21 January 2018

1 reference

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Thyrotropin activates both the cyclic AMP and the PIP2 cascades in CHO cells expressing the human cDNA of TSH receptor

21 January 2018

1 reference

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A synthetic peptide corresponding to the third cytoplasmic loop (residues 533 to 555) of the testicular follicle-stimulating hormone receptor affects signal transduction in rat testis membranes and in intact cultured rat Sertoli cells

21 January 2018

1 reference

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Somatic mutations in the thyrotropin receptor gene cause hyperfunctioning thyroid adenomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.14.7900

A model of the lutropin/choriogonadotropin receptor: insights into the structural and functional effects of constitutively activating mutations.

21 January 2018

1 reference

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Evidence for the direct involvement of transmembrane region 6 of the lutropin/choriogonadotropin receptor in activating Gs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.14.7900

Molecular mechanisms involved in muscarinic acetylcholine receptor-mediated G protein activation studied by insertion mutagenesis

21 January 2018

1 reference

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Requirement of rigid-body motion of transmembrane helices for light activation of rhodopsin

21 January 2018

1 reference

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21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.14.7900

Interactions between conserved residues in transmembrane helices 1, 2, and 7 of the thyrotropin-releasing hormone receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.14.7900

Brief report: congenital hyperthyroidism caused by a mutation in the thyrotropin-receptor gene

21 January 2018

1 reference

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Alterations in receptor activation and divalent cation activation of agonist binding by deletion of intracellular domains of the glucagon receptor

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.273.14.7900

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31 October 2017

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