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TNF superfamily member 10 (Q424394)

From Wikidata
mammalian protein found in Homo sapiens
  • Apo-2 ligand
  • tumor necrosis factor ligand superfamily member 10
  • TNF-related apoptosis inducing ligand TRAIL
  • tumor necrosis factor (ligand) superfamily, member 10
  • Apo-2L
  • TNFSF10
  • TNF-related apoptosis-inducing ligand
  • tumor necrosis factor superfamily member 10
  • chemokine tumor necrosis factor ligand superfamily member 10
  • tumor necrosis factor apoptosis-inducing ligand splice variant delta
  • tumor necrosis factor ligand 6A
  • Protein TRAIL
  • tumor necrosis factor (ligand) family, member 10
  • TRAIL
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    English
    TNF superfamily member 10
    mammalian protein found in Homo sapiens
    • Apo-2 ligand
    • tumor necrosis factor ligand superfamily member 10
    • TNF-related apoptosis inducing ligand TRAIL
    • tumor necrosis factor (ligand) superfamily, member 10
    • Apo-2L
    • TNFSF10
    • TNF-related apoptosis-inducing ligand
    • tumor necrosis factor superfamily member 10
    • chemokine tumor necrosis factor ligand superfamily member 10
    • tumor necrosis factor apoptosis-inducing ligand splice variant delta
    • tumor necrosis factor ligand 6A
    • Protein TRAIL
    • tumor necrosis factor (ligand) family, member 10
    • TRAIL

    Statements

    molecular function
    protein binding
    determination method or standard
    IPI
    9 references
    retrieved
    9 May 2019
    stated in
    Cullin3-based polyubiquitination and p62-dependent aggregation of caspase-8 mediate extrinsic apoptosis signaling
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50591
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Inhibition of vacuolar ATPase attenuates the TRAIL-induced activation of caspase-8 and modulates the trafficking of TRAIL receptosomes
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50591
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Identification of a novel proapoptotic function of resveratrol in fat cells: SIRT1-independent sensitization to TRAIL-induced apoptosis
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50591
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Identification of a novel pro-apoptotic role of NF-κB in the regulation of TRAIL- and CD95-mediated apoptosis of glioblastoma cells
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50591
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Bortezomib primes neuroblastoma cells for TRAIL-induced apoptosis by linking the death receptor to the mitochondrial pathway
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50591
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Triggering cell death: the crystal structure of Apo2L/TRAIL in a complex with death receptor 5
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50591
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Bortezomib primes glioblastoma, including glioblastoma stem cells, for TRAIL by increasing tBid stability and mitochondrial apoptosis
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50591
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Histone deacetylase inhibitors sensitize glioblastoma cells to TRAIL-induced apoptosis by c-myc-mediated downregulation of cFLIP
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50591
    determination method or standard
    IPI
    retrieved
    9 May 2019
    stated in
    Multivalent DR5 peptides activate the TRAIL death pathway and exert tumoricidal activity
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50591
    determination method or standard
    IPI
    cell component
    biological process
    positive regulation of extrinsic apoptotic signaling pathway
    determination method or standard
    IBA
    IDA
    IEA
    5 references
    retrieved
    9 May 2019
    stated in
    GOA
    curator
    Ensembl genome database project
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50591
    determination method or standard
    IEA
    retrieved
    9 May 2019
    stated in
    Identification of a novel proapoptotic function of resveratrol in fat cells: SIRT1-independent sensitization to TRAIL-induced apoptosis
    GOA
    curator
    UniProt
    UniProt protein ID
    P50591
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50591
    determination method or standard
    IDA
    retrieved
    9 May 2019
    stated in
    Bortezomib primes glioblastoma, including glioblastoma stem cells, for TRAIL by increasing tBid stability and mitochondrial apoptosis
    GOA
    curator
    UniProt
    UniProt protein ID
    P50591
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50591
    determination method or standard
    IDA
    retrieved
    9 May 2019
    stated in
    Histone deacetylase inhibitors sensitize glioblastoma cells to TRAIL-induced apoptosis by c-myc-mediated downregulation of cFLIP
    GOA
    curator
    UniProt
    UniProt protein ID
    P50591
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50591
    determination method or standard
    IDA
    retrieved
    9 May 2019
    stated in
    Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
    GOA
    curator
    GO Central
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50591
    determination method or standard
    IBA
    Gene Atlas image
    PBB GE TNFSF10 202688 at fs.png
    732 × 530; 10 KB
    0 references
    Commons category
    Apoptosis-2 ligand, apo2l or TRAIL
    0 references

    Identifiers

    MeSH descriptor ID
    D053221
    subject named as
    TNF-Related Apoptosis-Inducing Ligand
    0 references
     
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