Apoptotic sensitivity of colon cancer cells to histone deacetylase inhibitors is mediated by an Sp1/Sp3-activated transcriptional program involving immediate-early gene induction. (Q42426446)

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scientific article published on 12 January 2010

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English	Apoptotic sensitivity of colon cancer cells to histone deacetylase inhibitors is mediated by an Sp1/Sp3-activated transcriptional program involving immediate-early gene induction.	scientific article published on 12 January 2010

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scholarly article

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16 January 2020

Apoptotic sensitivity of colon cancer cells to histone deacetylase inhibitors is mediated by an Sp1/Sp3-activated transcriptional program involving immediate-early gene induction (English)

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16 January 2020

apoptotic process

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immediate early gene

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based on heuristic

inferred from title

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based on heuristic

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Courtney Nicholas

13

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16 January 2020

Anderly C. Chueh

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John M Mariadason

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Andrew J Wilson

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Lars Tögel

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Georgia A Corner

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16 January 2020

Naseem Ahmed

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Sanjay Goel

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Do-Sun Byun

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Shannon Nasser

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16 January 2020

Michele A Houston

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Minaxi Jhawer

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Helena J M Smartt

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16 January 2020

Lucas B Murray

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Barbara G Heerdt

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16 January 2020

Leonard H Augenlicht

16

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12 January 2010

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16 January 2020

Cancer Research

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16 January 2020

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609-620

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16 January 2020

2

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16 January 2020

A genecentric Human Protein Atlas for expression profiles based on antibodies

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HDACs and HDAC inhibitors in colon cancer

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Inhibitors of histone deacetylases induce tumor-selective cytotoxicity through modulating Aurora-A kinase

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Histone deacetylase inhibitors: molecular mechanisms of action

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Analysis of the apoptotic and therapeutic activities of histone deacetylase inhibitors by using a mouse model of B cell lymphoma

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Histone deacetylase inhibitor trichostatin a potentiates doxorubicin-induced apoptosis by up-regulating PTEN expression

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Anticancer activities of histone deacetylase inhibitors

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Upregulation of BAK by butyrate in the colon is associated with increased Sp3 binding.

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Induction of polyploidy by histone deacetylase inhibitor: a pathway for antitumor effects

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Overexpression of histone deacetylase 1 confers resistance to sodium butyrate-mediated apoptosis in melanoma cells through a p53-mediated pathway

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Signaling events for metallothionein induction

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Histone deacetylase inhibitors in cancer therapy: is transcription the primary target?

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Overexpression of Krüppel-like factor 4 in the human colon cancer cell line RKO leads to reduced tumorigenecity

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Transcriptional upregulation of the insulin-like growth factor binding protein IGFBP-3 by sodium butyrate increases IGF-independent apoptosis in human colonic adenoma-derived epithelial cells

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Histone deacetylase inhibitors all induce p21 but differentially cause tubulin acetylation, mitotic arrest, and cytotoxicity.

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Induction and superinduction of growth arrest and DNA damage gene 45 (GADD45) alpha and beta messenger RNAs by histone deacetylase inhibitors trichostatin A (TSA) and butyrate in SW620 human colon carcinoma cells

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Transcription factor Sp3 is regulated by acetylation

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The histone deacetylase inhibitor and chemotherapeutic agent suberoylanilide hydroxamic acid (SAHA) induces a cell-death pathway characterized by cleavage of Bid and production of reactive oxygen species

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Reversible disruption of pericentric heterochromatin and centromere function by inhibiting deacetylases

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The nucleosomal response associated with immediate-early gene induction is mediated via alternative MAP kinase cascades: MSK1 as a potential histone H3/HMG-14 kinase

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28 May 2018

Acetylation of general transcription factors by histone acetyltransferases

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28 May 2018

Goals for signal transduction pathways: linking up with transcriptional regulation

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Inhibition of histone deacetylase 6 acetylates and disrupts the chaperone function of heat shock protein 90: a novel basis for antileukemia activity of histone deacetylase inhibitors.

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1 reference

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Tumor-selective action of HDAC inhibitors involves TRAIL induction in acute myeloid leukemia cells

1 reference

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based on heuristic

inferred from PubMed ID database lookup

Inhibitors of histone deacetylases induce tumor-selective apoptosis through activation of the death receptor pathway

1 reference

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A Web-based Tool forin SilicoBiomarker Discovery Based on Tissue-specific Protein Profiles in Normal and Cancer Tissues

1 reference

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1 reference

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EMBOSS: the European Molecular Biology Open Software Suite

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Identifiers

10.1158/0008-5472.CAN-09-2327

1 reference

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1 reference

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1 reference

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