Critical contacts between the eukaryotic initiation factor 2B (eIF2B) catalytic domain and both eIF2beta and -2gamma mediate guanine nucleotide exchange. (Q42412345)

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scientific article published on 25 May 2007

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English	Critical contacts between the eukaryotic initiation factor 2B (eIF2B) catalytic domain and both eIF2beta and -2gamma mediate guanine nucleotide exchange.	scientific article published on 25 May 2007

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scholarly article

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31 December 2019

Critical contacts between the eukaryotic initiation factor 2B (eIF2B) catalytic domain and both eIF2beta and -2gamma mediate guanine nucleotide exchange (English)

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31 December 2019

Graham D. Pavitt

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31 December 2019

Jonathan P Richardson

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31 December 2019

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Sarah S Mohammad-Qureshi

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31 December 2019

Raphaël Haddad

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31 December 2019

Elizabeth J Hemingway

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25 May 2007

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31 December 2019

Molecular and Cellular Biology

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31 December 2019

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31 December 2019

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31 December 2019

5225-5234

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31 December 2019

Purification of FLAG-tagged eukaryotic initiation factor 2B complexes, subcomplexes, and fragments from Saccharomyces cerevisiae

1 reference

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Structural evidence for a common intermediate in small G protein-GEF reactions

1 reference

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An eIF5/eIF2 complex antagonizes guanine nucleotide exchange by eIF2B during translation initiation

1 reference

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Structure of archaeal translational initiation factor 2 betagamma-GDP reveals significant conformational change of the beta-subunit and switch 1 region

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The crystal structure of the carboxy-terminal domain of human translation initiation factor eIF5

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Crystal structure of the C-terminal domain of S.cerevisiae eIF5.

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Diversification of catalytic activities and ligand interactions in the protein fold shared by the sugar isomerases, eIF2B, DeoR transcription factors, acyl-CoA transferases and methenyltetrahydrofolate synthetase.

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The eukaryotic initiation factor (eIF) 5 HEAT domain mediates multifactor assembly and scanning with distinct interfaces to eIF1, eIF2, eIF3, and eIF4G

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The large spectrum of eIF2B-related diseases

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eIF2B, a mediator of general and gene-specific translational control

1 reference

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Translational regulation of GCN4 and the general amino acid control of yeast

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Heightened stress response in primary fibroblasts expressing mutant eIF2B genes from CACH/VWM leukodystrophy patients

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EIF2B5 mutations compromise GFAP+ astrocyte generation in vanishing white matter leukodystrophy

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Molecular mechanisms of translational control

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Decreased guanine nucleotide exchange factor activity in eIF2B-mutated patients

1 reference

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Mutations causing childhood ataxia with central nervous system hypomyelination reduce eukaryotic initiation factor 2B complex formation and activity

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X-ray structure of translation initiation factor eIF2gamma: implications for tRNA and eIF2alpha binding

1 reference

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Structure of the catalytic fragment of translation initiation factor 2B and identification of a critically important catalytic residue

1 reference

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28 May 2018

Structural snapshots of the mechanism and inhibition of a guanine nucleotide exchange factor

1 reference

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eIF2B-related disorders: antenatal onset and involvement of multiple organs

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28 May 2018

Characterization of the minimal catalytic domain within eIF2B: the guanine-nucleotide exchange factor for translation initiation

1 reference

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Analysis and reconstitution of translation initiation in vitro

1 reference

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Minimum requirements for the function of eukaryotic translation initiation factor 2.

1 reference

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Structural basis for nucleotide exchange and competition with tRNA in the yeast elongation factor complex eEF1A:eEF1Balpha

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A multifactor complex of eukaryotic initiation factors, eIF1, eIF2, eIF3, eIF5, and initiator tRNA(Met) is an important translation initiation intermediate in vivo

1 reference

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Identification of domains and residues within the epsilon subunit of eukaryotic translation initiation factor 2B (eIF2Bepsilon) required for guanine nucleotide exchange reveals a novel activation function promoted by eIF2B complex formation

1 reference

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GEFs: structural basis for their activation of small GTP-binding proteins

1 reference

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Conserved bipartite motifs in yeast eIF5 and eIF2Bepsilon, GTPase-activating and GDP-GTP exchange factors in translation initiation, mediate binding to their common substrate eIF2.

1 reference

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1 reference

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GTP hydrolysis controls stringent selection of the AUG start codon during translation initiation in Saccharomyces cerevisiae

1 reference

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Ligand interactions with eukaryotic translation initiation factor 2: role of the gamma-subunit

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Mutations in GCD11, the structural gene for eIF-2 gamma in yeast, alter translational regulation of GCN4 and the selection of the start site for protein synthesis.

1 reference

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1 reference

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1 reference

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1 reference

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Complex formation by positive and negative translational regulators of GCN4.

1 reference

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1 reference

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Direct binding of translation initiation factor eIF2gamma-G domain to its GTPase-activating and GDP-GTP exchange factors eIF5 and eIF2B epsilon

1 reference

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Structural switch of the gamma subunit in an archaeal aIF2 alpha gamma heterodimer.

1 reference

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12 December 2020

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31 December 2019

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