SRPK2 phosphorylates tau and mediates the cognitive defects in Alzheimer's disease (Q42401404)

29 October 2017

SRPK2 phosphorylates tau and mediates the cognitive defects in Alzheimer's disease (English)

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29 October 2017

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Yi Hong

1

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29 October 2017

Chi Bun Chan

2

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29 October 2017

Il-Sun Kwon

3

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29 October 2017

Xuekun Li

4

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29 October 2017

Mingke Song

5

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29 October 2017

Hyun-Pil Lee

6

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29 October 2017

Xia Liu

7

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29 October 2017

Pradoldej Sompol

8

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29 October 2017

Peng Jin

9

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29 October 2017

Hyoung-gon Lee

10

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29 October 2017

Shan Ping Yu

11

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29 October 2017

Keqiang Ye

12

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29 October 2017

language of work or name

English

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publication date

1 November 2012

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29 October 2017

11

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based on heuristic

inferred from page(s)

published in

Journal of Neuroscience

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29 October 2017

32

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29 October 2017

48

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29 October 2017

17262-17272

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describes a project that uses

29 October 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3518045/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

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Regulating SR protein phosphorylation through regions outside the kinase domain of SRPK1

28 May 2018

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Reduced spine density in specific regions of CA1 pyramidal neurons in two transgenic mouse models of Alzheimer's disease.

28 May 2018

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Post-translational modifications of tau protein: implications for Alzheimer's disease.

28 May 2018

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Serine-arginine protein kinases: a small protein kinase family with a large cellular presence

28 May 2018

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Amyloid-β and tau--a toxic pas de deux in Alzheimer's disease

28 May 2018

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Tau mislocalization to dendritic spines mediates synaptic dysfunction independently of neurodegeneration

28 May 2018

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The N-terminal fragment from caspase-cleaved serine/arginine protein-specific kinase2 (SRPK2) translocates into the nucleus and promotes apoptosis

28 May 2018

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RGS14 is a natural suppressor of both synaptic plasticity in CA2 neurons and hippocampal-based learning and memory

28 May 2018

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The role of tau kinases in Alzheimer's disease

28 May 2018

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Cross talk between microRNA and epigenetic regulation in adult neurogenesis

28 May 2018

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The novel squamosamide derivative FLZ enhances BDNF/TrkB/CREB signaling and inhibits neuronal apoptosis in APP/PS1 mice

28 May 2018

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Functional alterations in memory networks in early Alzheimer's disease

28 May 2018

1 reference

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Total and phosphorylated tau protein as biological markers of Alzheimer's disease

28 May 2018

1 reference

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Interaction of Akt-phosphorylated SRPK2 with 14-3-3 mediates cell cycle and cell death in neurons

28 May 2018

1 reference

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The neuronal expression of MYC causes a neurodegenerative phenotype in a novel transgenic mouse

28 May 2018

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Cell cycle re-entry mediated neurodegeneration and its treatment role in the pathogenesis of Alzheimer's disease

28 May 2018

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Serine/arginine protein-specific kinase 2 promotes leukemia cell proliferation by phosphorylating acinus and regulating cyclin A1

28 May 2018

1 reference

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Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model

28 May 2018

1 reference

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Cell division in the CNS: protective response or lethal event in post-mitotic neurons?

28 May 2018

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Cdk5 Modulation of mitogen-activated protein kinase signaling regulates neuronal survival

28 May 2018

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Do axonal defects in tau and amyloid precursor protein transgenic animals model axonopathy in Alzheimer's disease?

28 May 2018

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P70 S6 kinase mediates tau phosphorylation and synthesis

28 May 2018

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Regulated cellular partitioning of SR protein-specific kinases in mammalian cells

28 May 2018

1 reference

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Pseudophosphorylation and glycation of tau protein enhance but do not trigger fibrillization in vitro

28 May 2018

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Subicular Dendritic Arborization in Alzheimer's Disease Correlates with Neurofibrillary Tangle Density

28 May 2018

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Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction

28 May 2018

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Involvement of aberrant glycosylation in phosphorylation of tau by cdk5 and GSK-3beta

28 May 2018

1 reference

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Identification of SRPK1 and SRPK2 as the major cellular protein kinases phosphorylating hepatitis B virus core protein

28 May 2018

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Localization of serine kinases, SRPK1 (SFRSK1) and SRPK2 (SFRSK2), specific for the SR family of splicing factors in mouse and human chromosomes

28 May 2018

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The subcellular localization of SF2/ASF is regulated by direct interaction with SR protein kinases (SRPKs)

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3518045

Phosphorylation that detaches tau protein from microtubules (Ser262, Ser214) also protects it against aggregation into Alzheimer paired helical filaments

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3518045

The endogenous and cell cycle-dependent phosphorylation of tau protein in living cells: implications for Alzheimer's disease

28 May 2018

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Ectopic cell cycle proteins predict the sites of neuronal cell death in Alzheimer's disease brain.

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3518045

SRPK2: a differentially expressed SR protein-specific kinase involved in mediating the interaction and localization of pre-mRNA splicing factors in mammalian cells

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3518045

Regulated phosphorylation and dephosphorylation of tau protein: effects on microtubule interaction, intracellular trafficking and neurodegeneration

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3518045

Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red.

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3518045

Microtubule-associated protein tau is required for axonal neurite elaboration by neuroblastoma cells.

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3518045

Phosphorylation of recombinant tau by cAMP-dependent protein kinase. Identification of phosphorylation sites and effect on microtubule assembly.

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3518045

3R tau expression modifies behavior in transgenic mice.

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3518045

CDK11p58 represses vitamin D receptor-mediated transcriptional activation through promoting its ubiquitin-proteasome degradation.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3518045

Phosphorylation of human PRP28 by SRPK2 is required for integration of the U4/U6-U5 tri-snRNP into the spliceosome

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3518045

Sequential phosphorylation of tau protein by cAMP-dependent protein kinase and SAPK4/p38delta or JNK2 in the presence of heparin generates the AT100 epitope.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3518045

Tumor-suppressor PTEN affects tau phosphorylation, aggregation, and binding to microtubules

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3518045

Progressive age-related development of Alzheimer-like pathology in APP/PS1 mice

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3518045

Comparison of the neurofibrillary pathology in Alzheimer's disease and familial presenile dementia with tangles

16 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23197718

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1523/JNEUROSCI.3300-12.2012

1 reference

29 October 2017

1 reference

29 October 2017

1 reference