SIGNAL TRANSDUCTION. Structural basis for nucleotide exchange in heterotrimeric G proteins (Q42390741)

29 October 2017

SIGNAL TRANSDUCTION. Structural basis for nucleotide exchange in heterotrimeric G proteins (English)

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29 October 2017

David W Borhani

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Brian Kobilka

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object named as

Brian K Kobilka

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29 October 2017

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Aashish Manglik

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29 October 2017

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Wayne L Hubbell

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29 October 2017

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Ron O Dror

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29 October 2017

Thomas J Mildorf

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29 October 2017

Daniel Hilger

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29 October 2017

Daniel H Arlow

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29 October 2017

Ansgar Philippsen

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29 October 2017

Nicolas Villanueva

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29 October 2017

Zhongyu Yang

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29 October 2017

Michael T Lerch

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29 October 2017

Roger K Sunahara

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29 October 2017

David E Shaw

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29 October 2017

language of work or name

English

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publication date

1 June 2015

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29 October 2017

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29 October 2017

348

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29 October 2017

6241

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29 October 2017

1361-1365

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The guanine nucleotide exchange factor Ric-8A induces domain separation and Ras domain plasticity in Gαi1.

29 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4968074

Energetic analysis of the rhodopsin-G-protein complex links the α5 helix to GDP release

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4968074

Molecular signatures of G-protein-coupled receptors

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4968074

Signal activation and inactivation by the Gα helical domain: a long-neglected partner in G protein signaling

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4968074

Differences in intradomain and interdomain motion confer distinct activation properties to structurally similar Gα proteins

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4968074

Conformational changes in the G protein Gs induced by the β2 adrenergic receptor

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4968074

Structural flexibility of the G alpha s alpha-helical domain in the beta2-adrenoceptor Gs complex

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4968074

Crystal structure of the β2 adrenergic receptor-Gs protein complex

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4968074

A concerted mechanism for opening the GDP binding pocket and release of the nucleotide in hetero-trimeric G-proteins

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4968074

Interaction of a G protein with an activated receptor opens the interdomain interface in the alpha subunit

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4968074

Structural and kinetic modeling of an activating helix switch in the rhodopsin-transducin interface

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4968074

The structure and function of G-protein-coupled receptors

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4968074

G protein inactive and active forms investigated by simulation methods

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4968074

Heterotrimeric G protein activation by G-protein-coupled receptors

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4968074

Mechanism of the receptor-catalyzed activation of heterotrimeric G proteins

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4968074

The function of interdomain interactions in controlling nucleotide exchange rates in transducin

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4968074

G protein mechanisms: insights from structural analysis

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4968074

The 2.0 A crystal structure of a heterotrimeric G protein

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4968074

The structure of the G protein heterotrimer Gi alpha 1 beta 1 gamma 2

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4968074

Separate GTP binding and GTPase activating domains of a G alpha subunit

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4968074

Rapid GDP release from Gs alpha in patients with gain and loss of endocrine function

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4968074

Precision vs flexibility in GPCR signaling.

28 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4968074

Signal transfer from GPCRs to G proteins: role of the G alpha N-terminal region in rhodopsin-transducin coupling.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4968074

Molecular dynamics simulations of transducin: interdomain and front to back communication in activation and nucleotide exchange.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4968074

Rapid activation of transducin by mutations distant from the nucleotide-binding site: evidence for a mechanistic model of receptor-catalyzed nucleotide exchange by G proteins

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4968074

Dynamic properties of the guanine nucleotide binding protein alpha subunit and comparison of its guanosine triphosphate hydrolase domain with that of ras p21.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4968074

Receptor and betagamma binding sites in the alpha subunit of the retinal G protein transducin

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4968074

Atomic-level characterization of the structural dynamics of proteins

16 August 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAA5264

Structural determinants for regulation of phosphodiesterase by a G protein at 2.0 A

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAA5264

The 2.2 A crystal structure of transducin-alpha complexed with GTP gamma S

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAA5264

Extending the treatment of backbone energetics in protein force fields: limitations of gas-phase quantum mechanics in reproducing protein conformational distributions in molecular dynamics simulations

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAA5264

How robust are protein folding simulations with respect to force field parameterization?

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAA5264

Update of the CHARMM all-atom additive force field for lipids: validation on six lipid types

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAA5264

Structure and function of an irreversible agonist-β(2) adrenoceptor complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAA5264

Identification of two distinct inactive conformations of the beta2-adrenergic receptor reconciles structural and biochemical observations

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAA5264

CHARMM general force field: A force field for drug-like molecules compatible with the CHARMM all-atom additive biological force fields

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAA5264

Activation mechanism of the β2-adrenergic receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAA5264

Accurate and efficient integration for molecular dynamics simulations at constant temperature and pressure

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAA5264

A fast SHAKE algorithm to solve distance constraint equations for small molecules in molecular dynamics simulations

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAA5264

Reversible multiple time scale molecular dynamics

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAA5264

Gaussian split Ewald: A fast Ewald mesh method for molecular simulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAA5264

VMD: visual molecular dynamics

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAA5264

High sensitivity and versatility of the DEER experiment on nitroxide radical pairs at Q-band frequencies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAA5264

Increased sensitivity and extended range of distance measurements in spin-labeled membrane proteins: Q-band double electron-electron resonance and nanoscale bilayers

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAA5264

Significantly improved sensitivity of Q-band PELDOR/DEER experiments relative to X-band is observed in measuring the intercoil distance of a leucine zipper motif peptide (GCN4-LZ)

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAA5264

Conformational changes in the amino-terminal helix of the G protein alpha(i1) following dissociation from Gbetagamma subunit and activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAA5264

Mapping protein conformational heterogeneity under pressure with site-directed spin labeling and double electron-electron resonance

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAA5264

DEER distance measurements on proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAA5264

Rotamer libraries of spin labelled cysteines for protein studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAA5264

Crystal structure of the adenylyl cyclase activator Gsalpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAA5264

Structural Determinants of Affinity Enhancement between GoLoco Motifs and G-Protein Subunit Mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAA5264

What is the role of the helical domain of Gsalpha in the GTPase reaction?

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26089515

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Constant pressure molecular dynamics algorithms

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1126/SCIENCE.AAA5264

Mapping of effector binding sites of transducin alpha-subunit using G alpha t/G alpha i1 chimeras

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1126/SCIENCE.AAA5264

All-atom empirical potential for molecular modeling and dynamics studies of proteins

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1126/SCIENCE.AAA5264

Millisecond-scale molecular dynamics simulations on Anton

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1126/SCIENCE.AAA5264

Identifiers

DOI

10.1126/SCIENCE.AAA5264

1 reference

29 October 2017

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29 October 2017

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