paclitaxel (Q423762)

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paclitaxel
compost químic
    anglès
    paclitaxel
    chemical compound
    • BMS-181339-01
    • PAX
    • taxol
    • 5beta,20-epoxy-1,2-alpha,4,7beta,10beta,13alpha-hexahydroxytax-11-en-9-one 4,10-diacetate 2-benzoate 13-ester with (2R,3S)-N-benzoyl-3-phenylisoserine
    • taxol A

    Declaracions

    subclasse de
    taxoids anglès
    1 referència
    deduït de
    taxoids anglès
    massa
    853,331 unitat de massa atòmica
    1 referència
    afirmat a
    PubChem
    identificador PubChem
    36314
    llengua del terme, de l'obra o del nom
    anglès
    títol
    paclitaxel (anglès)
    data de consulta
    18 nov 2016
    SMILES canònic
    CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)OC(=O)C
    1 referència
    afirmat a
    PubChem
    identificador PubChem
    36314
    llengua del terme, de l'obra o del nom
    anglès
    títol
    paclitaxel (anglès)
    data de consulta
    18 nov 2016
    SMILES isomèric
    CC1=C2[C@H](C(=O)[C@@]3([C@H](C[C@@H]4[C@]([C@H]3[C@@H]([C@@](C2(C)C)(C[C@@H]1OC(=O)[C@@H]([C@H](C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)OC(=O)C
    1 referència
    afirmat a
    PubChem
    identificador PubChem
    36314
    llengua del terme, de l'obra o del nom
    anglès
    títol
    paclitaxel (anglès)
    data de consulta
    18 nov 2016
    trobat en el tàxon
    Taxus brevifolia
    34 referències
    afirmat a
    A Brief Survey of Taxus Alkaloids and Other Taxane Derivatives anglès
    afirmat a
    Biosynthesis of Taxol anglès
    afirmat a
    Concentrations of taxol and related taxanes in the needles of differentTaxus cultivars anglès
    afirmat a
    Purification and characterization of taxa-4(5),11(12)-diene synthase from Pacific yew (Taxus brevifolia) that catalyzes the first committed step of taxol biosynthesis anglès
    afirmat a
    Heterologous expression and characterization of a "Pseudomature" form of taxadiene synthase involved in paclitaxel (Taxol) biosynthesis and evaluation of a potential intermediate and inhibitors of the multistep diterpene cyclization reaction anglès
    afirmat a
    Embryo culture and taxane production inTaxus spp anglès
    afirmat a
    Free taxanes and the release of bound compounds having taxane antibody reactivity by xylanase in female, haploid-derived cell suspension cultures ofTaxus brevifolia anglès
    afirmat a
    Determination of taxol in Taxus species grown in Hungary by high-performance liquid chromatography-diode array detection effect of vegetative period anglès
    afirmat a
    Taxol content in the seeds of Taxus SPP anglès
    afirmat a
    Taxol partitioning in two-phase plant cell cultures of Taxus brevifolia anglès
    afirmat a
    Taxol formation in yew — Taxus anglès
    afirmat a
    Supercritical extraction of taxol from the bark of Taxus brevifolia anglès
    afirmat a
    Rapid screening for taxanes by tandem mass spectrometry anglès
    afirmat a
    High-performance liquid chromatographic assay of taxol anglès
    afirmat a
    Mechanism of taxadiene synthase, a diterpene cyclase that catalyzes the first step of taxol biosynthesis in Pacific yew anglès
    afirmat a
    Biosynthesis of taxoids. Mode of formation of the taxol side chain anglès
    afirmat a
    New taxanes from Taxus brevifolia anglès
    afirmat a
    Taxus spp. needles contain amounts of taxol comparable to the bark of Taxus brevifolia: analysis and isolation anglès
    afirmat a
    Taxol content in bark, wood, root, leaf, twig, and seedling from several Taxus species anglès
    afirmat a
    Effects of genetic, epigenetic, and environmental factors on taxol content in Taxus brevifolia and related species anglès
    afirmat a
    Taxol and Cephalomannine Concentrations in the Foliage and Bark of Shade-Grown and Sun-Exposed Taxus brevifolia Trees anglès
    afirmat a
    Determination of Taxanes in Taxus brevifolia Extracts by Tandem Mass Spectrometry and High-Performance Liquid Chromatography anglès
    afirmat a
    Brevitaxin, a new diterpenolignan from the bark of Taxus brevifolia anglès
    afirmat a
    Taxol and taxane formation in plant cell culture anglès
    afirmat a
    Neutral and basic taxoid contents in the needles of Taxus species anglès
    afirmat a
    Taxol biosynthesis: an update anglès
    afirmat a
    Cyclization of geranylgeranyl diphosphate to taxa-4(5),11(12)-diene is the committed step of taxol biosynthesis in Pacific yew anglès
    afirmat a
    A cDNA clone for taxadiene synthase, the diterpene cyclase that catalyzes the committed step of taxol biosynthesis anglès
    afirmat a
    HPLC Separation of Taxol and Cephalomannine anglès
    afirmat a
    Methodology for the Identification and Purification of Taxol and Cephalomannine from Taxus Callus Cultures anglès
    afirmat a
    EFFICIENT EXTRACTION OF PACLITAXEL AND RELATED TAXOIDS FROM LEAF TISSUE OF TAXUS USING A POTABLE SOLVENT SYSTEM anglès
    afirmat a
    Biosynthetic studies on taxol anglès
    afirmat a
    Biosynthetic Studies on Taxol anglès
    afirmat a
    Biosynthesis of Taxol anglès
    Taxus canadensis
    17 referències
    afirmat a
    Determination of taxane concentrations in Taxus canadensis clippings using high performance liquid chromatographic analysis with an internal standard anglès
    afirmat a
    Analysis of taxol and related taxanes fromtaxus canadensis using liquid chromatography combined with mass spectrometry or tandem mass spectrometry anglès
    afirmat a
    Taxol production and taxadiene synthase activity in Taxus canadensis cell suspension cultures anglès
    afirmat a
    Partial purification and characterization of acetyl coenzyme A: taxa-4(20),11(12)-dien-5alpha-ol O-acetyl transferase that catalyzes the first acylation step of taxol biosynthesis anglès
    afirmat a
    Preparative separation of taxol in normal- and reversed-phase operations anglès
    afirmat a
    Taxol content of various Taxus species in Hungary anglès
    afirmat a
    Two new taxanes from Taxus canadensis anglès
    afirmat a
    Biosynthetic building blocks of taxanes anglès
    afirmat a
    Challenges in the isolation of taxanes from Taxus canadensis by fast pyrolysis anglès
    afirmat a
    Oligosaccharides potentiate methyl jasmonate-induced production of paclitaxel in Taxus canadensis anglès
    afirmat a
    Rapid screening for taxanes by tandem mass spectrometry anglès
    afirmat a
    Taxus spp. needles contain amounts of taxol comparable to the bark of Taxus brevifolia: analysis and isolation anglès
    afirmat a
    Isolation of 9-Dihydro-13-acetylbaccatin III from Taxus canadensis anglès
    afirmat a
    Isolation of labeled 9-dihydrobaccatin III and related taxoids from cell cultures of taxuscell cultures of taxus canadensis elicited with m anglès
    afirmat a
    Neutral and basic taxoid contents in the needles of Taxus species anglès
    afirmat a
    Yew (taxus) species - chemical and morphological variations anglès
    afirmat a
    Seasonal Changes in the Concentration of Major Taxanes in the Biomass of Wild Canada Yew (Taxus canadensis. Marsh.) anglès
    teix
    41 referències
    afirmat a
    Methodology for the Identification and Purification of Taxol and Cephalomannine from Taxus Callus Cultures anglès
    afirmat a
    Immunoenzymatic methods applied to the search for bioactive taxoids from Taxus baccata anglès
    afirmat a
    Taxol on the surface of leaves and inside the needles of three species and two varieties of Taxus anglès
    afirmat a
    Sample preparation for taxol and cephalomannine determination in various organs of Taxus sp anglès
    afirmat a
    Analysis of taxol, 10-deacetylbaccatin III and related compounds in Taxus baccata anglès
    afirmat a
    Taxol production in suspension cultures of Taxus baccata anglès
    afirmat a
    Production of taxanes by Taxus baccata plant cells anglès
    afirmat a
    Taxol content of Irish yews. anglès
    afirmat a
    Seasonal changes in the concentrations of four taxoids in Taxus baccata L. during the autumn-spring period anglès
    afirmat a
    Seasonal variations in the content of taxanes in the bark of Taxus baccata L. anglès
    afirmat a
    INVESTIGATIONS ON PREPARATIVE THIN-LAYER CHROMATOGRAPHIC SEPARATION OF TAXOIDS FROM TAXUS BACCATA L. anglès
    afirmat a
    Concentrations of taxol and related taxanes in the needles of differentTaxus cultivars anglès
    afirmat a
    Screening for pharmaceutically important taxoids in Taxus baccata var. Aurea corr. with CC/SPE/HPLC-PDA procedure anglès
    afirmat a
    Yew (taxus) species - chemical and morphological variations anglès
    afirmat a
    Neutral and basic taxoid contents in the needles of Taxus species anglès
    afirmat a
    Seasonal variation of neutral and basic taxoid contents in shoots of European Yew (Taxus baccata) anglès
    afirmat a
    Taxol content in the bark of Himalayan Yew in relation to tree age and sex. anglès
    afirmat a
    Taxanes in Taxus baccata pollen: cardiotoxicity and/or allergenicity? anglès
    afirmat a
    Taxus spp. needles contain amounts of taxol comparable to the bark of Taxus brevifolia: analysis and isolation anglès
    afirmat a
    Taxol content in bark, wood, root, leaf, twig, and seedling from several Taxus species anglès
    afirmat a
    Effects of genetic, epigenetic, and environmental factors on taxol content in Taxus brevifolia and related species anglès
    afirmat a
    Relationships between the structures of taxol and baccatine III derivatives and their in vitro action on the disassembly of mammalian brain and Physarum amoebal microtubules anglès
    afirmat a
    New bioactive taxoids from cell cultures of Taxus baccata anglès
    afirmat a
    Taxanes from Taxus baccata anglès
    afirmat a
    A yew in Israel, new taxane derivatives anglès
    afirmat a
    Taxol content in the seeds of Taxus SPP anglès
    afirmat a
    Taxol content of various Taxus species in Hungary anglès
    afirmat a
    Taxol content in the storage samples of the needles of Himalayan Taxus baccata and their extracts anglès
    afirmat a
    Application of supercritical fluid extraction and supercritical fluid chromatography to the production of taxanes as anti-cancer drugs anglès
    afirmat a
    Production of Taxol® and baccatin III by a selected Taxus baccata callus line and its derived cell suspension culture anglès
    afirmat a
    Antimicrobial activity of the heartwood of Taxus baccata anglès
    afirmat a
    Method of isolating taxol from Taxus baccata anglès
    afirmat a
    High-Speed Countercurrent Chromatography Separation of Taxol and Related Diterpenoids fromTaxus Baccata anglès
    afirmat a
    Rapid screening for taxanes by tandem mass spectrometry anglès
    afirmat a
    Determination of paclitaxel and related diterpenoids in plant extracts by high-performance liquid chromatography with UV detection in high-performance liquid chromatography–mass spectrometry anglès
    afirmat a
    Taxol production in bioreactors: Kinetics of biomass accumulation, nutrient uptake, and taxol production by cell suspensions of Taxus baccata anglès
    afirmat a
    Induction of geranylgeranyl diphosphate synthase activity and taxane accumulation in Taxus baccata cell cultures after elicitation by methyl jasmonate anglès
    afirmat a
    Geranylgeranyl diphosphate synthase activity and taxane production in Taxus baccata cells anglès
    afirmat a
    Taxol transport in Taxus baccata cell suspension cultures anglès
    afirmat a
    A Yew in Israel, New Taxane Derivatives anglès
    afirmat a
    Production of Taxanes in a Bioreactor by Taxus baccata Cells anglès
    Taxus wallichiana
    24 referències
    afirmat a
    Novel taxane diterpenes from Taxus sumatrana with the first C-21 taxane ester anglès
    afirmat a
    Taxol and its related taxoids from the needles of Taxus sumatrana. anglès
    afirmat a
    Chemical Study of Indonesian Medicinal Plants anglès
    afirmat a
    Novel Taxane Diterpenes from Taxus sumatrana with the First C-21 Taxane Ester anglès
    afirmat a
    High Performance Liquid Chromatographic Determination of Taxol and Related Taxanes from Taxus Callus Cultures anglès
    afirmat a
    Improved taxol yield in cell suspension culture of Taxus wallichiana (Himalayan yew) anglès
    afirmat a
    Semi-preparative separation and purification of taxol analogs by high-speed countercurrent chromatography anglès
    afirmat a
    Analysis of taxol and major taxoids in Himalayan yew, Taxus wallichiana anglès
    afirmat a
    Variation in content of taxol and related taxanes in Eastern Himalayan populations of Taxus wallichiana anglès
    afirmat a
    Taxol Related Diterpenes from the Roots of Taxus yunnanensis anglès
    afirmat a
    Wallifoliol, a taxol congener with a novel carbon skeleton, from Himalayan Taxus wallichiana anglès
    afirmat a
    Taxoids from the barks of Taxus wallichiana anglès
    afirmat a
    A New Taxane Diterpene fromTaxus yunnanensis anglès
    afirmat a
    New taxane diterpenoids from the leaves and twigs of Taxus sumatrana anglès
    afirmat a
    Diterpenes and sesquiterpenes from the bark of Taxus yunnanensis anglès
    afirmat a
    New Taxane Diterpenoids from Taxus yunnanensis anglès
    afirmat a
    Chemical constituents of Taxus species anglès
    afirmat a
    The taxoid constituents of the roots of Taxus wallichiana anglès
    afirmat a
    Production of Paclitaxel and Baccatin III in a 20-L Airlift Bioreactor by a Cell Suspension of Taxus wallichiana anglès
    afirmat a
    LARGE-SCALE PROCESS FOR HIGH PURITY TAXOL FROM BARK EXTRACT OFTAXUS YUNNANESIS anglès
    afirmat a
    A Large Scale Separation of Taxanes from the Bark Extract of Taxus yunnanesis and 1H- and 13C-NMR Assignments for 7-epi-10-Deacetyltaxol anglès
    afirmat a
    Stimulation of taxol production and excretion in Taxus spp cell cultures by rare earth chemical lanthanum anglès
    afirmat a
    High Performance Liquid Chromatographic Determination of Taxol and Related Taxanes from Texas Callus Cultures anglès
    afirmat a
    Constituents from Taxus species anglès
    Taxus cuspidata
    49 referències
    afirmat a
    Methodology for the Identification and Purification of Taxol and Cephalomannine from Taxus Callus Cultures anglès
    afirmat a
    Taxol on the surface of leaves and inside the needles of three species and two varieties of Taxus anglès
    afirmat a
    Microwave-Assisted Extraction of Taxanes fromTaxusBiomass anglès
    afirmat a
    Sample preparation for taxol and cephalomannine determination in various organs of Taxus sp anglès
    afirmat a
    High Performance Liquid Chromatographic Determination of Taxol and Related Taxanes from Taxus Callus Cultures anglès
    afirmat a
    Taxol production in suspension cultures of Taxus baccata anglès
    afirmat a
    Distribution and amounts of taxol in different shoot parts of Taxus cuspidata anglès
    afirmat a
    Qualitative and quantitative determination of taxol and related compounds inTaxus cuspidata Sieb et Zucc anglès
    afirmat a
    Roots of hydroponically grown Taxus plants as a source of taxol and related taxanes anglès
    afirmat a
    Taxol and related compounds in Korean native yews (Taxus cuspidata) anglès
    afirmat a
    Continuous production of taxol by cell culture of taxus cuspidata. anglès
    afirmat a
    Recycling High-Speed Countercurrent Chromatography for Separation of Taxol and Cephalomannine anglès
    afirmat a
    Concentrations of taxol and related taxanes in the needles of differentTaxus cultivars anglès
    afirmat a
    Studies on factors influencing stability and recovery of paclitaxel from suspension media and cultures of Taxus cuspidata cv Densiformis by high-performance liquid chromatography anglès
    afirmat a
    Yew (taxus) species - chemical and morphological variations anglès
    afirmat a
    Neutral and basic taxoid contents in the needles of Taxus species anglès
    afirmat a
    Efficient Paclitaxel Production using Protoplasts Isolated from Cultured Cells of Taxus cuspidata anglès
    afirmat a
    Taxus spp. needles contain amounts of taxol comparable to the bark of Taxus brevifolia: analysis and isolation anglès
    afirmat a
    Taxol content in bark, wood, root, leaf, twig, and seedling from several Taxus species anglès
    afirmat a
    Determination of taxol by high-performance liquid chromatography-thermospray mass spectrometry anglès
    afirmat a
    Effects of genetic, epigenetic, and environmental factors on taxol content in Taxus brevifolia and related species anglès
    afirmat a
    Taxuspines A ∼ C, new taxoids from Japanese yew Taxus cuspidata inhibiting drug transport activity of P-glycoprotein in multidrug-resistant cells anglès
    afirmat a
    Taxuspines E ∼ H and J, new taxoids from the Japanese yew Taxus cuspidata anglès
    afirmat a
    A taxoid from Taxus cuspidata var. nana anglès
    afirmat a
    A taxoid from the needles of the Japanese yew, Taxus cuspidata anglès
    afirmat a
    A Novel Rearranged Taxoid from Needles of the Japanese Yew, Taxus cuspidata Sieb. et Zucc anglès
    afirmat a
    Taxol content in the seeds of Taxus SPP anglès
    afirmat a
    Effects of taxoids from Taxus cuspidata on microtubule depolymerization and vincristine accumulation in MDR cells anglès
    afirmat a
    Supercritical fluid extraction of paclitaxel and baccatin III from needles of taxus cuspidata anglès
    afirmat a
    Taxol content of various Taxus species in Hungary anglès
    afirmat a
    Taxol (paclitaxel) production using free and immobilized cells of Taxus cuspidata anglès
    afirmat a
    Accelerated solvent extraction of paclitaxel and related compounds from the bark of taxus cuspidata anglès
    afirmat a
    A Novel Method of Isolating Taxanes from Cell Suspension Cultures of Yew (TaxusSpp.) anglès
    afirmat a
    Taxol anglès
    afirmat a
    Supercritical fluid extraction of taxol and baccatin III from needles of Taxus cuspidata anglès
    afirmat a
    RECOVERY OF TAXOL FROM THE EXTRACT OF TAXUS CUSPIDATE CALLUS CULTURES WITH AL2O3 CHROMATOGRAPHY anglès
    afirmat a
    Kinetics of two-liquid-phase Taxus cuspidata cell culture for production of Taxol anglès
    afirmat a
    Purification of S-PG05 using Simulated Moving Bed Chromatography anglès
    afirmat a
    Large-scale growth and taxane production in cell cultures of Taxus cuspidata (Japanese yew) using a novel bioreactor anglès
    afirmat a
    Immunocytochemical Localization of Taxol in Taxus cuspidata anglès
    afirmat a
    Rapid screening for taxanes by tandem mass spectrometry anglès
    afirmat a
    Improved growth and taxol yield in developing calli of Taxus cuspidata by medium composition modification. anglès
    afirmat a
    Influence of water extracts from the surface of two yew (Taxus) species on mites (Tetranychus urticae) anglès
    afirmat a
    Partial purification and characterization of acetyl coenzyme A: taxa-4(20),11(12)-dien-5alpha-ol O-acetyl transferase that catalyzes the first acylation step of taxol biosynthesis anglès
    afirmat a
    Taxol biosynthesis: differential transformations of taxadien-5 alpha-ol and its acetate ester by cytochrome P450 hydroxylases from Taxus suspension cells anglès
    afirmat a
    Taxol biosynthesis: taxane 13 alpha-hydroxylase is a cytochrome P450-dependent monooxygenase anglès
    afirmat a
    Taxol biosynthesis: molecular cloning of a benzoyl-CoA:taxane 2alpha-O-benzoyltransferase cDNA from taxus and functional expression in Escherichia coli anglès
    afirmat a
    High Performance Liquid Chromatographic Determination of Taxol and Related Taxanes from Texas Callus Cultures anglès
    afirmat a
    Taxol production in nodule cultures of Taxus anglès
    malaltia tractada
    estatuts legal (medicina)
    boxed warning anglès
    1 referència
    URL de la referència
    https://nctr-crs.fda.gov/fdalabel/ui/spl-summaries/criteria/343802
    títol
    FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links. (anglès)
    categoria de Commons
    Paclitaxel
    0 referències

    Identificadors

    identificador BNE
    XX554373
    0 referències
    número NSC
    125973
    0 referències
    758645
    0 referències
    número CE
    608-826-9
    1 referència
    afirmat a
    ECHA Substance Infocard database anglès
    identificador ECHA InfoCard
    100.127.725
    data de consulta
    27 des 2018
    títol
    (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-Dodecahydro-4,6,9,11,12,12b-hexahydroxy-4a,8,13,13-tetramethyl-7,11-methano-5H-cyclodeca(3,4)benz(1,2-b)oxet-5-one 6,12b-diacetate, 12-benzoate, 9-ester with (2R,3S)-N-benzoyl-3-phenylisoserine (anglès)
    citació
    CAS no.: 33069-62-4 (anglès)
    identificador ECHA InfoCard
    100.127.725
    1 referència
    afirmat a
    ECHA Substance Infocard database anglès
    identificador ECHA InfoCard
    100.127.725
    data de consulta
    27 des 2018
    títol
    (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-Dodecahydro-4,6,9,11,12,12b-hexahydroxy-4a,8,13,13-tetramethyl-7,11-methano-5H-cyclodeca(3,4)benz(1,2-b)oxet-5-one 6,12b-diacetate, 12-benzoate, 9-ester with (2R,3S)-N-benzoyl-3-phenylisoserine (anglès)
    citació
    CAS no.: 33069-62-4 (anglès)
    identificador MeSH
    D017239
    anomenat com a
    Paclitaxel
    0 referències
    identificador DeCS
    30485
    0 referències
    identificador NALT
    34126
    0 referències
    PDB
    codi UNSPSC
    51111904
    0 referències
     
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