Caspase-8, association with Alzheimer's Disease and functional analysis of rare variants (Q42371397)

28 October 2017

Caspase-8, association with Alzheimer's Disease and functional analysis of rare variants (English)

1 reference

28 October 2017

0 references

Alfredo Ramirez

13

0 references

Lindsay A. Farrer

Lindsay A Farrer

15

0 references

Hilkka Soininen

11

Hilkka Soininen

1 reference

28 October 2017

16

Jonathan L Haines

1 reference

28 October 2017

14

Martin Scherer

1 reference

28 October 2017

Gerard D Schellenberg

20

Gerard D Schellenberg

1 reference

28 October 2017

8

Adam Naj

1 reference

Margaret A. Pericak-Vance

28 October 2017

17

Margaret A Pericak-Vance

1 reference

28 October 2017

19

Carlos Cruchaga

1 reference

28 October 2017

18

Wendy H Raskind

1 reference

28 October 2017

9

Frank Jessen

1 reference

28 October 2017

Jan Rehker

1

1 reference

28 October 2017

Johanna Rodhe

2

1 reference

28 October 2017

Ryan R Nesbitt

3

1 reference

28 October 2017

Evan A Boyle

4

1 reference

28 October 2017

Beth K Martin

5

1 reference

28 October 2017

Jenny Lord

6

1 reference

28 October 2017

Ilker Karaca

7

1 reference

28 October 2017

Seppo Helisalmi

10

1 reference

28 October 2017

Mikko Hiltunen

12

1 reference

28 October 2017

Bertrand Joseph

21

1 reference

28 October 2017

Zoran Brkanac

22

1 reference

28 October 2017

language of work or name

English

0 references

publication date

6 October 2017

1 reference

28 October 2017

1 reference

28 October 2017

12

1 reference

28 October 2017

10

1 reference

28 October 2017

e0185777

1 reference

Creative Commons Attribution 4.0 International

28 October 2017

start time

6 October 2017

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

29 May 2018

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More alive than dead: non-apoptotic roles for caspases in neuronal development, plasticity and disease.

29 May 2018

1 reference

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Elucidating the Role of TREM2 in Alzheimer's Disease

29 May 2018

1 reference

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Disease Progression-Dependent Effects of TREM2 Deficiency in a Mouse Model of Alzheimer's Disease.

29 May 2018

1 reference

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Influence of Coding Variability in APP-Aβ Metabolism Genes in Sporadic Alzheimer's Disease

29 May 2018

1 reference

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TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques

29 May 2018

1 reference

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Do Microglia Default on Network Maintenance in Alzheimer's Disease?

29 May 2018

1 reference

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The Phyre2 web portal for protein modeling, prediction and analysis

29 May 2018

1 reference

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Redox regulation of autophagy in healthy brain and neurodegeneration

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5630132

TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer's disease mouse models.

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5630132

Innate immunity in Alzheimer's disease

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5630132

Caspases: therapeutic targets in neurologic disease

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5630132

Rare-variant association analysis: study designs and statistical tests

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5630132

Alzheimer's disease risk genes and mechanisms of disease pathogenesis

29 May 2018

1 reference

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Coding variants in TREM2 increase risk for Alzheimer's disease

29 May 2018

1 reference

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MIPgen: optimized modeling and design of molecular inversion probes for targeted resequencing

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5630132

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5630132

An update of animal models of Alzheimer disease with a reevaluation of plaque depositions

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5630132

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5630132

TREM2 Variants in Alzheimer's Disease

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5630132

Variant of TREM2 Associated with the Risk of Alzheimer's Disease

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5630132

A death effector domain chain DISC model reveals a crucial role for caspase-8 chain assembly in mediating apoptotic cell death

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5630132

Stoichiometry of the CD95 death-inducing signaling complex: experimental and modeling evidence for a death effector domain chain model

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5630132

Apoptotic and non-apoptotic roles of caspases in neuronal physiology and pathophysiology

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5630132

Caspases in synaptic plasticity

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5630132

Alzheimer's disease and the amyloid cascade hypothesis: a critical review

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5630132

Mouse models of Alzheimer's disease

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5630132

Caspase-8 regulates TNF-α-induced epithelial necroptosis and terminal ileitis.

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5630132

The executioners sing a new song: killer caspases activate microglia.

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5630132

Tumor necrosis factor-alpha and the roles it plays in homeostatic and degenerative processes within the central nervous system

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5630132

Quality control and preprocessing of metagenomic datasets

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5630132

The role of caspases in Alzheimer's disease; potential novel therapeutic opportunities

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5630132

Fast and accurate long-read alignment with Burrows-Wheeler transform

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5630132

The mitochondrial impairment, oxidative stress and neurodegeneration connection: reality or just an attractive hypothesis?

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5630132

A critical function for beta-amyloid precursor protein in neuronal migration revealed by in utero RNA interference

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5630132

Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5630132

To be or not to be (inflamed)--is that the question in anti-inflammatory drug therapy of neurodegenerative disorders?

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5630132

Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5630132

Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5630132

γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5630132

PANTHER: a browsable database of gene products organized by biological function, using curated protein family and subfamily classification

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5630132

Caspases, apoptosis, and Alzheimer disease: causation, correlation, and confusion

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5630132

Caspase requirement for neuronal apoptosis and neurodegeneration

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5630132

Energy requirement for caspase activation and neuronal cell death

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5630132

A second cytotoxic proteolytic peptide derived from amyloid beta-protein precursor

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5630132

KEGG: kyoto encyclopedia of genes and genomes

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5630132

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5630132

Neuronal apoptosis induced by beta-amyloid is mediated by caspase-8.

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5630132

Early-onset autosomal dominant Alzheimer disease: prevalence, genetic heterogeneity, and mutation spectrum

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5630132

Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-beta precursor protein and amyloidogenic A beta peptide formation

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5630132

Changes in caspase expression in Alzheimer's disease: comparison with development and aging.

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5630132

Pro-caspase-3 is a major physiologic target of caspase-8.

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5630132

Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally.

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5630132

Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5630132

In vitro phosphorylation of the cytoplasmic domain of the amyloid precursor protein by glycogen synthase kinase-3beta

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5630132

Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5630132

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5630132

Amyloid plaque core protein in Alzheimer disease and Down syndrome

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5630132

Early-onset Alzheimer's disease caused by mutations at codon 717 of the beta-amyloid precursor protein gene

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5630132

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5630132

Alzheimer's disease: the amyloid cascade hypothesis

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5630132

TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5630132

TREM2 variants and risk of Alzheimer's disease: a meta-analysis.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5630132

Caspase signalling controls microglia activation and neurotoxicity.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5630132

Caspase-3 triggers early synaptic dysfunction in a mouse model of Alzheimer's disease.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5630132

Activation of caspase-8 in the Alzheimer's disease brain.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5630132

Activated caspase-3 expression in Alzheimer's and aged control brain: correlation with Alzheimer pathology.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5630132

Activation of caspase-3 in beta-amyloid-induced apoptosis of cultured rat cortical neurons

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5630132

Alternative, non-secretase processing of Alzheimer's beta-amyloid precursor protein during apoptosis by caspase-6 and -8.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5630132

In Vitro Phosphorylation of the Cytoplasmic Domain of the Amyloid Precursor Protein by Glycogen Synthase Kinase-3β

17 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0185777

Prevalence of Alzheimer disease in US states

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/28985224

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Caspase-3 activity in hippocampal slices reflects changes in synaptic plasticity

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/28985224

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PONE.0185777

1 reference

28 October 2017

1 reference

28 October 2017

PubMed publication ID

28985224

1 reference