Pyruvate kinase M2 is a poor prognostic marker of and a therapeutic target in ovarian cancer (Q42339119)

27 October 2017

Pyruvate kinase M2 is a poor prognostic marker of and a therapeutic target in ovarian cancer (English)

1 reference

27 October 2017

1 reference

Tai-Kuang Chao

1

1 reference

27 October 2017

Tien-Shuo Huang

2

1 reference

27 October 2017

Yu-Ping Liao

3

1 reference

27 October 2017

Rui-Lan Huang

4

1 reference

27 October 2017

Po-Hsuan Su

5

1 reference

27 October 2017

Hueng-Yuan Shen

6

1 reference

27 October 2017

Hung-Cheng Lai

7

1 reference

27 October 2017

Yu-Chi Wang

8

1 reference

27 October 2017

language of work or name

English

0 references

publication date

28 July 2017

1 reference

27 October 2017

1 reference

27 October 2017

12

1 reference

27 October 2017

7

1 reference

27 October 2017

e0182166

1 reference

Creative Commons Attribution 4.0 International

27 October 2017

start time

28 July 2017

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

PKM2 promotes stemness of breast cancer cell by through Wnt/β-catenin pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5533430

Metformin prevents aggressive ovarian cancer growth driven by high-energy diet: similarity with calorie restriction

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5533430

Shikonin induces apoptosis and inhibits migration of ovarian carcinoma cells by inhibiting the phosphorylation of Src and FAK.

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5533430

29 May 2018

Cancer statistics, 2015

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5533430

Metformin inhibits ovarian cancer growth and increases sensitivity to paclitaxel in mouse models.

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5533430

ALDH1A1 maintains ovarian cancer stem cell-like properties by altered regulation of cell cycle checkpoint and DNA repair network signaling

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5533430

Cancer treatment and survivorship statistics, 2014

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5533430

Shikonin-loaded antibody-armed nanoparticles for targeted therapy of ovarian cancer

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5533430

Sensitizing the therapeutic efficacy of taxol with shikonin in human breast cancer cells

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5533430

Drug screening identifies niclosamide as an inhibitor of breast cancer stem-like cells

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5533430

PKM2 inhibitor shikonin suppresses TPA-induced mitochondrial malfunction and proliferation of skin epidermal JB6 cells

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5533430

Targeting cancer metabolism

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5533430

Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5533430

Overexpression of the M2 isoform of pyruvate kinase is an adverse prognostic factor for signet ring cell gastric cancer

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5533430

Deregulated MYC expression induces dependence upon AMPK-related kinase 5.

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5533430

Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5533430

Targeting cancer metabolism: a therapeutic window opens

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5533430

Shikonin and its analogs inhibit cancer cell glycolysis by targeting tumor pyruvate kinase-M2.

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5533430

Lovastatin induces apoptosis of ovarian cancer cells and synergizes with doxorubicin: potential therapeutic relevance

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5533430

Understanding the Warburg effect: the metabolic requirements of cell proliferation

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5533430

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5533430

Pyruvate kinase M2 is a phosphotyrosine-binding protein

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5533430

Shikonin-induced apoptosis involves caspase-3 activity in a human bladder cancer cell line (T24).

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5533430

The biology of cancer: metabolic reprogramming fuels cell growth and proliferation

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5533430

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5533430

On the Origin of Cancer Cells

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5533430

Cellular pharmacology studies of shikonin derivatives.

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5533430

The M1- and M2-type isozymes of rat pyruvate kinase are produced from the same gene by alternative RNA splicing

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5533430

Antitumor activity of shikonin and its derivatives

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5533430

Antitumor activity of shikonin, alkannin and their derivatives. II. X-ray analysis of cyclo-alkannin leucoacetate, tautomerism of alkannin and cyclo-alkannin and antitumor activity of alkannin derivatives

29 May 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/28753677

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

DNA methylation as a biomarker for the detection of hidden carcinoma in endometrial atypical hyperplasia

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/28753677

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Clinical trial on the effects of shikonin mixture on later stage lung cancer

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/28753677

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PONE.0182166

1 reference

27 October 2017

1 reference

27 October 2017

1 reference