Use of partition coefficients in flow-limited physiologically-based pharmacokinetic modeling (Q42242976)

19 October 2017

Use of partition coefficients in flow-limited physiologically-based pharmacokinetic modeling (English)

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19 October 2017

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3

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19 October 2017

Matthew D Thompson

1

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PMCID

3400708

19 October 2017

Daniel A Beard

series ordinal

2

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19 October 2017

26 May 2012

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Journal of Pharmacokinetics and Pharmacodynamics

19 October 2017

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19 October 2017

39

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19 October 2017

4

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19 October 2017

313-327

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https://scigraph.springernature.com/pub.10.1007/s10928-012-9252-6

19 October 2017

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The role of physiologically based pharmacokinetic modeling in regulatory review

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Physiologically based pharmacokinetic tissue compartment model selection in drug development and risk assessment

26 October 2017

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Development of appropriate equations for physiologically based pharmacokinetic modeling of permeability-limited and flow-limited transport

26 October 2017

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Effects of anti-VEGF on predicted antibody biodistribution: roles of vascular volume, interstitial volume, and blood flow

26 October 2017

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Fuzzy simulation of pharmacokinetic models: case study of whole body physiologically based model of diazepam

26 October 2017

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Physiological parameter values for physiologically based pharmacokinetic models

26 October 2017

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Cotinine as a biomarker of environmental tobacco smoke exposure

26 October 2017

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Tissue dosimetry, pharmacokinetic modeling, and interspecies scaling factors

26 October 2017

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Physiologic pharmacokinetic models: relevance, experience, and future trends

26 October 2017

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A vial-equilibration method to evaluate the drug-metabolizing enzyme activity for volatile hydrocarbons

26 October 2017

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Physiologically based pharmacokinetic modeling 1: predicting the tissue distribution of moderate-to-strong bases.

26 October 2017

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Development of a whole body physiologically based model to characterise the pharmacokinetics of benzodiazepines. 1: Estimation of rat tissue-plasma partition ratios

29 May 2018

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Prediction of pharmacokinetics prior to in vivo studies. II. Generic physiologically based pharmacokinetic models of drug disposition

29 May 2018

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Prediction of diazepam disposition in the rat and man by a physiologically based pharmacokinetic model.

29 May 2018

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Constant-rate infusion of nicotine and cotinine. I. A physiological pharmacokinetic analysis of the cotinine disposition, and effects on clearance and distribution in the rat.

29 May 2018

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Potential error in the measurement of tissue to blood distribution coefficients in physiological pharmacokinetic modeling. Residual tissue blood. I. Theoretical considerations

29 May 2018

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Physiologically based pharmacokinetic modeling of deltamethrin: development of a rat and human diffusion-limited model.

29 May 2018

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Physiologically based pharmacokinetic modeling of drug disposition in rat and human: a fuzzy arithmetic approach

17 August 2018

1 reference

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Development of a physiologically based pharmacokinetic model for deltamethrin in the adult male Sprague-Dawley rat.

17 August 2018

1 reference

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Diazepam pharamacokinetics from preclinical to phase I using a Bayesian population physiologically based pharmacokinetic model with informative prior distributions in WinBUGS.

17 August 2018

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Volume of distribution at steady state for a linear pharmacokinetic system with peripheral elimination

17 August 2018

1 reference

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Prediction of pharmacokinetics prior to in vivo studies. 1. Mechanism-based prediction of volume of distribution.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400708

A priori prediction of tissue:plasma partition coefficients of drugs to facilitate the use of physiologically-based pharmacokinetic models in drug discovery.

17 August 2018

1 reference

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Tissue distribution of 14C-diazepam and its metabolites in rats.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400708

Partition coefficients and their uses

17 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS10928-012-9252-6

Distribution of blood (Fe 59) and plasma (I 131) volumes of rats determined by liquid nitrogen freezing

21 January 2018

1 reference

12 December 2020

A physiologically based pharmacokinetic model for nicotine and cotinine in man

1 reference

12 December 2020

Potential error in the measurement of tissue to blood distribution coefficients in physiological pharmacokinetic modeling. Residual tissue blood. II. Distribution of phencyclidine in the rat

1 reference

12 December 2020

Physiologically based pharmacokinetic model for beta-lactam antibiotics I: Tissue distribution and elimination in rats

1 reference

12 December 2020

Physiologically based pharmacokinetics of cyclosporine A: extension to tissue distribution kinetics in rats and scale-up to human

1 reference

12 December 2020

10.1007/S10928-012-9252-6

Identifiers

DOI

1 reference

19 October 2017

1 reference

19 October 2017

1 reference

PMCID

3400708