Nanoparticle-mediated combinatorial targeting of multiple human dendritic cell (DC) subsets leads to enhanced T cell activation via IL-15-dependent DC crosstalk. (Q42202638)

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scientific article published on 30 July 2014

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English	Nanoparticle-mediated combinatorial targeting of multiple human dendritic cell (DC) subsets leads to enhanced T cell activation via IL-15-dependent DC crosstalk.	scientific article published on 30 July 2014

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25080481%20AND%20SRC:MED&resulttype=core&format=json

11 March 2020

Nanoparticle-mediated combinatorial targeting of multiple human dendritic cell (DC) subsets leads to enhanced T cell activation via IL-15-dependent DC crosstalk (English)

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11 March 2020

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11 March 2020

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Ragy Ragheb

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11 March 2020

Tarek M Fahmy

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11 March 2020

Madhav V Dhodapkar

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11 March 2020

Kavita M Dhodapkar

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11 March 2020

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30 July 2014

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11 March 2020

Journal of Immunology

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11 March 2020

193

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11 March 2020

5

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11 March 2020

2297-2305

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11 March 2020

Enhancement of surface ligand display on PLGA nanoparticles with amphiphilic ligand conjugates

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12 December 2020

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Cutting edge: the role of IFN-α receptor and MyD88 signaling in induction of IL-15 expression in vivo

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Surface modification of biodegradable polyesters with fatty acid conjugates for improved drug targeting.

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The impact of nanoparticle ligand density on dendritic-cell targeted vaccines

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IL-15-induced human DC efficiently prime melanoma-specific naive CD8+ T cells to differentiate into CTL.

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SOX2-specific adaptive immunity and response to immunotherapy in non-small cell lung cancer

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Design opportunities for actively targeted nanoparticle vaccines

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Antigen delivery to early endosomes eliminates the superiority of human blood BDCA3+ dendritic cells at cross presentation

1 reference

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Protective T cell immunity in mice following protein-TLR7/8 agonist-conjugate immunization requires aggregation, type I IFN, and multiple DC subsets.

1 reference

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Differential antigen processing by dendritic cell subsets in vivo

1 reference

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Nano-particle vaccination combined with TLR-7 and -9 ligands triggers memory and effector CD8⁺ T-cell responses in melanoma patients

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Mouse CD8alpha+ DCs and human BDCA3+ DCs are major producers of IFN-lambda in response to poly IC.

1 reference

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Yellow fever vaccine YF-17D activates multiple dendritic cell subsets via TLR2, 7, 8, and 9 to stimulate polyvalent immunity

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The C-type lectin receptor CLEC9A mediates antigen uptake and (cross-)presentation by human blood BDCA3+ myeloid dendritic cells

1 reference

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12 December 2020

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Characterization of human DNGR-1+ BDCA3+ leukocytes as putative equivalents of mouse CD8alpha+ dendritic cells

1 reference

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Targeting dendritic cells--why bother?

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Programming the magnitude and persistence of antibody responses with innate immunity

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IFN-λs and BDCA3+/CD8α+ dendritic cells: towards the design of novel vaccine adjuvants?

1 reference

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Trans-presentation: a novel mechanism regulating IL-15 delivery and responses

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Selective blockade of inhibitory Fcgamma receptor enables human dendritic cell maturation with IL-12p70 production and immunity to antibody-coated tumor cells

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Frequent and specific immunity to the embryonal stem cell-associated antigen SOX2 in patients with monoclonal gammopathy

1 reference

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12 December 2020

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Targeting DC-SIGN via its neck region leads to prolonged antigen residence in early endosomes, delayed lysosomal degradation, and cross-presentation.

1 reference

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12 December 2020

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Interleukin-15-induced CD56(+) myeloid dendritic cells combine potent tumor antigen presentation with direct tumoricidal potential

1 reference

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12 December 2020

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Inflammasome-activating nanoparticles as modular systems for optimizing vaccine efficacy

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12 December 2020

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Targeted PLGA nano- but not microparticles specifically deliver antigen to human dendritic cells via DC-SIGN in vitro

1 reference

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12 December 2020

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Targeted delivery of TLR ligands to human and mouse dendritic cells strongly enhances adjuvanticity

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Nanogel-based delivery of mycophenolic acid ameliorates systemic lupus erythematosus in mice

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CD8α+ dendritic cell trans presentation of IL-15 to naive CD8+ T cells produces antigen-inexperienced T cells in the periphery with memory phenotype and function

1 reference

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SOX2 is an amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomas

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Division of labor, plasticity, and crosstalk between dendritic cell subsets.

1 reference

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1 reference

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Targeting Uptake Receptors on Human Plasmacytoid Dendritic Cells Triggers Antigen Cross-Presentation and Robust Type I IFN Secretion

1 reference

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Identifiers

10.4049/JIMMUNOL.1400489

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25080481%20AND%20SRC:MED&resulttype=core&format=json

11 March 2020

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Europe PubMed Central

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11 March 2020

1 reference

Europe PubMed Central

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11 March 2020

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