Nonsense and missense mutations in FCY2 and FCY1 genes are responsible for flucytosine resistance and flucytosine-fluconazole cross-resistance in clinical isolates of Candida lusitaniae. (Q42183289)

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English	Nonsense and missense mutations in FCY2 and FCY1 genes are responsible for flucytosine resistance and flucytosine-fluconazole cross-resistance in clinical isolates of Candida lusitaniae.	scientific article

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scholarly article

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27 January 2020

Nonsense and missense mutations in FCY2 and FCY1 genes are responsible for flucytosine resistance and flucytosine-fluconazole cross-resistance in clinical isolates of Candida lusitaniae (English)

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27 January 2020

5-fluorocytosine

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inferred from title

Gwenaël Ruprich-Robert

3

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27 January 2020

7

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27 January 2020

Florence Chapeland-Leclerc

8

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27 January 2020

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Martine Florent

1

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27 January 2020

Thierry Noël

2

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27 January 2020

Bruno Da Silva

4

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27 January 2020

Valérie Fitton-Ouhabi

5

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27 January 2020

Christiane Chastin

6

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27 January 2020

language of work or name

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publication date

4 May 2009

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27 January 2020

Antimicrobial Agents and Chemotherapy

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27 January 2020

53

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27 January 2020

7

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27 January 2020

2982-2990

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27 January 2020

Recent insights into the mechanisms of antifungal resistance

1 reference

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Multilocus sequence typing for differentiation of strains of Candida tropicalis

1 reference

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26 October 2017

Novel 5-flucytosine-resistant clade of Candida dubliniensis from Saudi Arabia and Egypt identified by Cd25 fingerprinting

1 reference

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26 October 2017

Inactivation of the FCY2 gene encoding purine-cytosine permease promotes cross-resistance to flucytosine and fluconazole in Candida lusitaniae.

1 reference

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26 October 2017

Molecular mechanisms of primary resistance to flucytosine in Candida albicans

1 reference

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26 October 2017

Clade-specific flucytosine resistance is due to a single nucleotide change in the FUR1 gene of Candida albicans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2704628

26 October 2017

Flucytosine resistance is restricted to a single genetic clade of Candida albicans

1 reference

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26 October 2017

Direct sorting of the yeast uracil permease to the endosomal system is controlled by uracil binding and Rsp5p-dependent ubiquitylation.

1 reference

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26 October 2017

Colony morphology switching of Candida lusitaniae and acquisition of multidrug resistance during treatment of a renal infection in a newborn: case report and review of the literature

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The 1.14 A crystal structure of yeast cytosine deaminase: evolution of nucleotide salvage enzymes and implications for genetic chemotherapy

1 reference

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26 October 2017

Flucytosine-fluconazole cross-resistance in purine-cytosine permease-deficient Candida lusitaniae clinical isolates: indirect evidence of a fluconazole uptake transporter

1 reference

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Crystal structure of yeast cytosine deaminase. Insights into enzyme mechanism and evolution

1 reference

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26 October 2017

Candida lusitaniae infections in the era of fluconazole availability

1 reference

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26 October 2017

Mechanisms of fungal resistance: an overview

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26 October 2017

Resistance of Candida species to antifungal agents: molecular mechanisms and clinical consequences

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26 October 2017

Alternative identification test relying upon sexual reproductive abilities of Candida lusitaniae strains isolated from hospitalized patients

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Candida lusitaniae: a cause of breakthrough fungemia in cancer patients

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26 October 2017

Flucytosine: a review of its pharmacology, clinical indications, pharmacokinetics, toxicity and drug interactions

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26 October 2017

Uracil-induced down-regulation of the yeast uracil permease.

1 reference

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26 October 2017

Gapped BLAST and PSI-BLAST: a new generation of protein database search programs

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Evaluation of a flow cytofluorometric method for rapid determination of amphotericin B susceptibility of yeast isolates

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CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

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26 October 2017

Fatal septicemia due to amphotericin B-resistant Candida lusitaniae.

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26 October 2017

The genetic basis of resistance to 5-fluorocytosine in Candida species and Cryptococcus neoformans

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Application of DNA typing methods to epidemiology and taxonomy of Candida species

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Differential involvement of histidine kinase receptors in pseudohyphal development, stress adaptation, and drug sensitivity of the opportunistic yeast Candida lusitaniae.

1 reference

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29 May 2018

Molecular mechanism of flucytosine resistance in Candida lusitaniae: contribution of the FCY2, FCY1, and FUR1 genes to 5-fluorouracil and fluconazole cross-resistance.

1 reference

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17 August 2018

Development of an integrative transformation system for the opportunistic pathogenic yeast Candida lusitaniae using URA3 as a selection marker

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17 August 2018

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17 August 2018

Evidence for a dynamic role for proline376 in the purine-cytosine permease of Saccharomyces cerevisiae

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12 December 2020

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Comparative evaluation of a commercial system for identification of Candida lusitaniae

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Screening of an intragenic second-site suppressor of purine-cytosine permease from Saccharomyces cerevisiae. Possible role of Ser272 in the base translocation process

1 reference

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Identifiers

10.1128/AAC.00880-08

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27 January 2020

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27 January 2020

1 reference

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27 January 2020

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