Intra-islet PACAP protects pancreatic β-cells against glucotoxicity and lipotoxicity (Q42166780)

17 October 2017

title

Intra-islet PACAP protects pancreatic β-cells against glucotoxicity and lipotoxicity (English)

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17 October 2017

3

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17 October 2017

Masanori Nakata

1

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17 October 2017

Norihito Shintani

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2

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17 October 2017

Akemichi Baba

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4

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17 October 2017

Toshihiko Yada

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5

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17 October 2017

publication date

12 May 2010

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Journal of Molecular Neuroscience

17 October 2017

published in

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17 October 2017

volume

42

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17 October 2017

issue

3

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17 October 2017

page(s)

404-410

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Glucolipotoxicity: fuel excess and beta-cell dysfunction.

17 October 2017

cites work

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12 December 2020

Signaling mechanisms underlying the insulinotropic effect of pituitary adenylate cyclase-activating polypeptide in HIT-T15 cells

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12 December 2020

Increased uncoupling protein-2 levels in beta-cells are associated with impaired glucose-stimulated insulin secretion: mechanism of action

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12 December 2020

Chronic palmitate but not oleate exposure induces endoplasmic reticulum stress, which may contribute to INS-1 pancreatic beta-cell apoptosis

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12 December 2020

Beta-cell dysfunction induced by chronic hyperglycemia. Current ideas on mechanism of impaired glucose-induced insulin secretion

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12 December 2020

PACAP deficient mice display reduced carbohydrate intake and PACAP activates NPY-containing neurons in the rat hypothalamic arcuate nucleus.

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12 December 2020

Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets: evidence that beta-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated.

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12 December 2020

Glucagon-like peptide-1 prevents beta cell glucolipotoxicity

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12 December 2020

Adenovirus-mediated overexpression of uncoupling protein-2 in pancreatic islets of Zucker diabetic rats increases oxidative activity and improves beta-cell function.

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12 December 2020

Glucose and tolbutamide induce apoptosis in pancreatic beta-cells. A process dependent on intracellular Ca2+ concentration

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12 December 2020

Glucagon-like peptide-1-(7-36)amide and a rise in cyclic adenosine 3',5'-monophosphate increase cytosolic free Ca2+ in rat pancreatic beta-cells by enhancing Ca2+ channel activity

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12 December 2020

Pituitary adenylate cyclase-activating polypeptide (PACAP): occurrence in rodent pancreas and effects on insulin and glucagon secretion in the mouse

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12 December 2020

Attenuation by PACAP of glutamate-induced neurotoxicity in cultured retinal neurons

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12 December 2020

Free fatty acid-induced beta-cell defects are dependent on uncoupling protein 2 expression

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12 December 2020

Pituitary adenylate cyclase activating polypeptide stimulates insulin release from the isolated perfused rat pancreas

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12 December 2020

Glucagon-like peptide-1 and exendin-4 stimulate beta-cell neogenesis in streptozotocin-treated newborn rats resulting in persistently improved glucose homeostasis at adult age.

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12 December 2020

Glucagon-like peptide-I analogs: effects on insulin secretion and adenosine 3',5'-monophosphate formation

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12 December 2020

Impaired beta-cell functions induced by chronic exposure of cultured human pancreatic islets to high glucose

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12 December 2020

Pituitary adenylate cyclase-activating polypeptide (PACAP) decreases ischemic neuronal cell death in association with IL-6.

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12 December 2020

Altered psychomotor behaviors in mice lacking pituitary adenylate cyclase-activating polypeptide (PACAP).

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12 December 2020

The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes

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12 December 2020

Cytosolic Ca2+ responses to sub-picomolar and nanomolar PACAP in pancreatic beta-cells are mediated by VPAC2 and PAC1 receptors

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12 December 2020

Pituitary adenylate cyclase-activating polypeptide receptors mediating insulin secretion in rodent pancreatic islets are coupled to adenylate cyclase but not to PLC.

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12 December 2020

Glucose-insensitivity induced by Ca(2+) toxicity in islet beta-cells and its prevention by PACAP.

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12 December 2020

Resistin induces insulin resistance in pancreatic islets to impair glucose-induced insulin release

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12 December 2020

Overexpression of PACAP in transgenic mouse pancreatic beta-cells enhances insulin secretion and ameliorates streptozotocin-induced diabetes.

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12 December 2020

Pituitary adenylate cyclase activating polypeptide is an extraordinarily potent intra-pancreatic regulator of insulin secretion from islet beta-cells

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12 December 2020

PACAP is expressed in secretory granules of insulin and glucagon cells in human and rodent pancreas. Evidence for generation of cAMP compartments uncoupled from hormone release in diabetic islets

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12 December 2020

PACAP in the glucose and energy homeostasis: physiological role and therapeutic potential

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12 December 2020

Signal transduction in insulin secretion: comparison between fuel stimuli and receptor agonists

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12 December 2020

The role of the free cytosolic calcium level in beta-cell signal transduction by gastric inhibitory polypeptide and glucagon-like peptide I(7-37).

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12 December 2020

Pituitary adenylate cyclase-activating polypeptide stimulates insulin and glucagon secretion in humans

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12 December 2020

Pituitary adenylate cyclase-activating polypeptide (PACAP) is an islet substance serving as an intra-islet amplifier of glucose-induced insulin secretion in rats

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12 December 2020

Isolation of a novel 38 residue-hypothalamic polypeptide which stimulates adenylate cyclase in pituitary cells

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12 December 2020

Essentiality of circulating fatty acids for glucose-stimulated insulin secretion in the fasted rat.

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12 December 2020

10.1007/S12031-010-9383-4

Identifiers

DOI

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Dimensions Publication ID

17 October 2017

1052423599

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