Inhibition of histone deacetylase overcomes rapamycin-mediated resistance in diffuse large B-cell lymphoma by inhibiting Akt signaling through mTORC2 (Q42152675)

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English	Inhibition of histone deacetylase overcomes rapamycin-mediated resistance in diffuse large B-cell lymphoma by inhibiting Akt signaling through mTORC2	scientific article

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scholarly article

1 reference

Europe PubMed Central

17 October 2017

Inhibition of histone deacetylase overcomes rapamycin-mediated resistance in diffuse large B-cell lymphoma by inhibiting Akt signaling through mTORC2 (English)

1 reference

Europe PubMed Central

17 October 2017

B-cell lymphoma

1 reference

based on heuristic

inferred from title

diffuse large B-cell lymphoma

1 reference

based on heuristic

inferred from title

Scott H Kaufmann

5

1 reference

Europe PubMed Central

17 October 2017

4

object named as

Shaji Kumar

1 reference

Europe PubMed Central

17 October 2017

author name string

Mamta Gupta

1

1 reference

Europe PubMed Central

17 October 2017

Stephen M Ansell

2

1 reference

Europe PubMed Central

17 October 2017

Anne J Novak

3

1 reference

Europe PubMed Central

17 October 2017

Thomas E Witzig

6

1 reference

Europe PubMed Central

17 October 2017

language of work or name

0 references

publication date

29 July 2009

1 reference

Europe PubMed Central

17 October 2017

1 reference

Europe PubMed Central

17 October 2017

114

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Europe PubMed Central

17 October 2017

2926-2935

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Europe PubMed Central

17 October 2017

14

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Europe PubMed Central

17 October 2017

Enhancing mammalian target of rapamycin (mTOR)-targeted cancer therapy by preventing mTOR/raptor inhibition-initiated, mTOR/rictor-independent Akt activation

1 reference

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Low-dose, single-agent temsirolimus for relapsed mantle cell lymphoma: a phase 2 trial in the North Central Cancer Treatment Group

1 reference

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Targeting the PI3K/Akt/mTOR pathway: effective combinations and clinical considerations

1 reference

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Vorinostat in cutaneous T-cell lymphoma

1 reference

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Suberoylanilide hydroxamic acid (SAHA; vorinostat) suppresses translation of cyclin D1 in mantle cell lymphoma cells

1 reference

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Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma

1 reference

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Vorinostat for treatment of cutaneous manifestations of advanced primary cutaneous T-cell lymphoma

1 reference

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HDACs, histone deacetylation and gene transcription: from molecular biology to cancer therapeutics

1 reference

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Role of phosphatidylinositol 3'-kinase/AKT pathway in diffuse large B-cell lymphoma survival

1 reference

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29 May 2018

mTOR and cancer: insights into a complex relationship

1 reference

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A phase I study of intravenous LBH589, a novel cinnamic hydroxamic acid analogue histone deacetylase inhibitor, in patients with refractory hematologic malignancies

1 reference

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Mammalian target of rapamycin inhibition induces cell cycle arrest in diffuse large B cell lymphoma (DLBCL) cells and sensitises DLBCL cells to rituximab.

1 reference

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Rituximab-CHOP versus CHOP alone or with maintenance rituximab in older patients with diffuse large B-cell lymphoma

1 reference

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29 May 2018

Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756203

29 May 2018

Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer

1 reference

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29 May 2018

Growing roles for the mTOR pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756203

29 May 2018

Histone acetylation-independent effect of histone deacetylase inhibitors on Akt through the reshuffling of protein phosphatase 1 complexes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2756203

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The Akt-mTOR tango and its relevance to cancer

1 reference

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29 May 2018

Activation of Akt and eIF4E survival pathways by rapamycin-mediated mammalian target of rapamycin inhibition.

1 reference

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29 May 2018

An expanding role for mTOR in cancer

1 reference

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Phase II trial of single-agent temsirolimus (CCI-779) for relapsed mantle cell lymphoma

1 reference

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Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

1 reference

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Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

1 reference

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Lost in translation: dysregulation of cap-dependent translation and cancer

1 reference

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Deactylase inhibitors disrupt cellular complexes containing protein phosphatases and deacetylases

1 reference

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Signaling network model of chromatin

1 reference

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29 May 2018

The phosphatidylinositol 3-Kinase AKT pathway in human cancer

1 reference

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29 May 2018

Histone deacetylases and cancer: causes and therapies

1 reference

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Phosphorylation of mammalian eIF4E by Mnk1 and Mnk2: tantalizing prospects for a role in translation.

1 reference

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Expression of the eukaryotic translation initiation factors 4E and 2alpha in non-Hodgkin's lymphomas

1 reference

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Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism

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Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors

1 reference

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Attenuation of a phosphorylation-dependent activator by an HDAC-PP1 complex

1 reference

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CHOP chemotherapy plus rituximab compared with CHOP alone in elderly patients with diffuse large-B-cell lymphoma

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17 August 2018

Identifiers

10.1182/BLOOD-2009-05-220889

1 reference

Europe PubMed Central

17 October 2017

1 reference

Europe PubMed Central

17 October 2017

1 reference

Europe PubMed Central

17 October 2017

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