Human rheumatoid arthritis tissue production of IL-17A drives matrix and cartilage degradation: synergy with tumour necrosis factor-alpha, Oncostatin M and response to biologic therapies. (Q42136310)

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scientific article published on 23 July 2009

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English	Human rheumatoid arthritis tissue production of IL-17A drives matrix and cartilage degradation: synergy with tumour necrosis factor-alpha, Oncostatin M and response to biologic therapies.	scientific article published on 23 July 2009

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3 February 2020

Human rheumatoid arthritis tissue production of IL-17A drives matrix and cartilage degradation: synergy with tumour necrosis factor-alpha, Oncostatin M and response to biologic therapies (English)

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rheumatoid arthritis

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Douglas J Veale

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Jennifer B McCormick

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Ronan Hugh Mullan

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Owen P O'Sullivan

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Owen Sullivan

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Oliver FitzGerald

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Oliver Fitzgerald

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Mary Connolly

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Barry Bresnihan

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23 July 2009

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Arthritis Research and Therapy

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R113

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https://scigraph.springernature.com/pub.10.1186/ar2772

0 references

Induction, function and regulation of IL-17-producing T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2745795

29 May 2018

Amelioration of epidermal hyperplasia by TNF inhibition is associated with reduced Th17 responses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2745795

29 May 2018

Amplifying elements of arthritis and joint destruction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2745795

29 May 2018

Interleukin-17 stimulates C-reactive protein expression in hepatocytes and smooth muscle cells via p38 MAPK and ERK1/2-dependent NF-kappaB and C/EBPbeta activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2745795

29 May 2018

IL-17A versus IL-17F induced intracellular signal transduction pathways and modulation by IL-17RA and IL-17RC RNA interference in AGS gastric adenocarcinoma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2745795

29 May 2018

Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2745795

29 May 2018

Synovial membrane cytokine expression is predictive of joint damage progression in rheumatoid arthritis: a two-year prospective study (the DAMAGE study cohort).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2745795

29 May 2018

Radiographic joint damage in rheumatoid arthritis is associated with differences in cartilage turnover and can be predicted by serum biomarkers: an evaluation from 1 to 4 years after diagnosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2745795

29 May 2018

Molecular therapeutic targets in rheumatoid arthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2745795

29 May 2018

Interleukin-17 family members and inflammation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2745795

29 May 2018

Regulation of matrix biology by matrix metalloproteinases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2745795

29 May 2018

Connective tissue metabolism in patients with unclassified polyarthritis and early rheumatoid arthritis. Relationship to disease activity, bone mineral density, and radiographic outcome.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2745795

29 May 2018

Effector function of type II collagen-stimulated T cells from rheumatoid arthritis patients: cross-talk between T cells and synovial fibroblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2745795

29 May 2018

Association of matrix metalloproteinase 3 promoter genotype with disease outcome in rheumatoid arthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2745795

29 May 2018

Increased expression of interleukin 23 p19 and p40 in lesional skin of patients with psoriasis vulgaris

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2745795

29 May 2018

Chemokines and chemokine receptors in rheumatoid arthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2745795

29 May 2018

Angiogenesis and chemokines in rheumatoid arthritis and other systemic inflammatory rheumatic diseases.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2745795

29 May 2018

Interleukin 17 synergises with tumour necrosis factor alpha to induce cartilage destruction in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2745795

29 May 2018

Interleukin 17 induces cartilage collagen breakdown: novel synergistic effects in combination with proinflammatory cytokines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2745795

29 May 2018

Interleukin 17 (IL-17) induces collagenase-3 production in human osteoarthritic chondrocytes via AP-1 dependent activation: differential activation of AP-1 members by IL-17 and IL-1beta

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2745795

29 May 2018

IL-17 derived from juxta-articular bone and synovium contributes to joint degradation in rheumatoid arthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2745795

29 May 2018

Contribution of interleukin 17 to synovium matrix destruction in rheumatoid arthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2745795

29 May 2018

IL-4 gene therapy for collagen arthritis suppresses synovial IL-17 and osteoprotegerin ligand and prevents bone erosion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2745795

29 May 2018

Reduction of interleukin-17-induced inhibition of chondrocyte proteoglycan synthesis in intact murine articular cartilage by interleukin-4.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2745795

29 May 2018

IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2745795

29 May 2018

Circulating levels of matrix metalloproteinases MMP-3 and MMP-1, tissue inhibitor of metalloproteinases 1 (TIMP-1), and MMP-1/TIMP-1 complex in rheumatic disease. Correlation with clinical activity of rheumatoid arthritis versus other surrogate mark

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2745795

29 May 2018

Enhancing effect of IL-17 on IL-1-induced IL-6 and leukemia inhibitory factor production by rheumatoid arthritis synoviocytes and its regulation by Th2 cytokines.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2745795

29 May 2018

Herpesvirus Saimiri encodes a new cytokine, IL-17, which binds to a novel cytokine receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2745795

29 May 2018

T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2745795

29 May 2018

The american rheumatism association 1987 revised criteria for the classification of rheumatoid arthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2745795

29 May 2018

Cytokines and cytokine inhibitors or antagonists in rheumatoid arthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2745795

29 May 2018

Studies of the articular cartilage proteoglycan aggrecan in health and osteoarthritis. Evidence for molecular heterogeneity and extensive molecular changes in disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2745795

29 May 2018

Blockade of tumor necrosis factor in collagen-induced arthritis reveals a novel immunoregulatory pathway for Th1 and Th17 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2745795

17 August 2018

Interleukin-17 gene expression in patients with rheumatoid arthritis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2745795

17 August 2018

Associations between HLA-DRB1, RANK, RANKL, OPG, and IL-17 genotypes and disease severity phenotypes in Japanese patients with early rheumatoid arthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2745795

17 August 2018

The clinical role of IL-23p19 in patients with rheumatoid arthritis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2745795

17 August 2018

Serum matrix metalloproteinase 3 is an independent predictor of structural damage progression in patients with ankylosing spondylitis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2745795

17 August 2018

In vitro and in situ expression of IL-23 by keratinocytes in healthy skin and psoriasis lesions: enhanced expression in psoriatic skin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2745795

17 August 2018

Interleukin-17 receptor deficiency results in impaired synovial expression of interleukin-1 and matrix metalloproteinases 3, 9, and 13 and prevents cartilage destruction during chronic reactivated streptococcal cell wall-induced arthritis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2745795

17 August 2018

Oncostatin M in combination with tumor necrosis factor alpha induces cartilage damage and matrix metalloproteinase expression in vitro and in vivo.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2745795

17 August 2018

Serum MMP-3 and MMP-1 and progression of joint damage in early rheumatoid arthritis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2745795

17 August 2018

Overexpression of IL-17 in the knee joint of collagen type II immunized mice promotes collagen arthritis and aggravates joint destruction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2745795

17 August 2018

The role of arthroscopy in early arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19627579

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human interleukin-17: A T cell-derived proinflammatory cytokine produced by the rheumatoid synovium

1 reference

https://pubmed.ncbi.nlm.nih.gov/19627579

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Long-term course and outcome of functional capacity in rheumatoid arthritis: the effect of disease activity and radiologic damage over time

1 reference

https://pubmed.ncbi.nlm.nih.gov/19627579

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-17 acts independently of TNF-alpha under arthritic conditions

1 reference

https://pubmed.ncbi.nlm.nih.gov/19627579

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

[Correlations between serum matrix metalloproteinase (MMP-1, MMP-3, MMP-9, MMP-13) concentrations and markers of disease activity in early rheumatoid arthritis]

1 reference

https://pubmed.ncbi.nlm.nih.gov/19627579

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oncostatin M induces angiogenesis and cartilage degradation in rheumatoid arthritis synovial tissue and human cartilage cocultures

1 reference

https://pubmed.ncbi.nlm.nih.gov/19627579

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

T cell dependence of chronic destructive murine arthritis induced by repeated local activation of toll-like receptor–driven pathways: Crucial role of both interleukin-1β and interleukin-17

1 reference

https://pubmed.ncbi.nlm.nih.gov/19627579

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Serum and synovial fluid levels of p40 IL12/23 in spondyloarthropathy patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/19627579

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

How to read radiographs according to the Sharp/van der Heijde method

1 reference

https://pubmed.ncbi.nlm.nih.gov/19627579

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-1-independent role of IL-17 in synovial inflammation and joint destruction during collagen-induced arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19627579

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Relationships of matrix metalloproteinases and their inhibitors to cartilage proteoglycan and collagen turnover and inflammation as revealed by analyses of synovial fluids from patients with rheumatoid arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19627579

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Can serum biomarker assays measure the progression of cartilage degeneration in osteoarthritis?

1 reference

https://pubmed.ncbi.nlm.nih.gov/19627579

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Association of interleukin-18 expression with enhanced levels of both interleukin-1beta and tumor necrosis factor alpha in knee synovial tissue of patients with rheumatoid arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19627579

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-17 stimulates the production and expression of proinflammatory cytokines, IL-beta and TNF-alpha, by human macrophages

1 reference

https://pubmed.ncbi.nlm.nih.gov/19627579

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of oncostatin M in animal and human connective tissue collagen turnover and its localization within the rheumatoid joint

1 reference

https://pubmed.ncbi.nlm.nih.gov/19627579

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Treatment with anti-TNF-alpha antibody infliximab reduces serum IL-15 levels in patients with rheumatoid arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19627579

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prostaglandin E2 exacerbates collagen-induced arthritis in mice through the inflammatory interleukin-23/interleukin-17 axis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19627579

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Early changes in serum type ii collagen biomarkers predict radiographic progression at one year in inflammatory arthritis patients after biologic therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/19627579

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biomarkers predict radiographic progression in early rheumatoid arthritis and perform well compared with traditional markers

1 reference

https://pubmed.ncbi.nlm.nih.gov/19627579

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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3 February 2020

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3 February 2020

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3 February 2020

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