Effects of naturally-arising HIV Nef mutations on cytotoxic T lymphocyte recognition and Nef's functionality in primary macrophages. (Q42115872)

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5 February 2020

title

Effects of naturally-arising HIV Nef mutations on cytotoxic T lymphocyte recognition and Nef's functionality in primary macrophages (English)

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5 February 2020

3

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5 February 2020

Shinya Suzu

4

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5 February 2020

Takamasa Ueno

6

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5 February 2020

author name string

Philip Mwimanzi

1

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5 February 2020

Zafrul Hasan

2

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5 February 2020

Masafumi Takiguchi

5

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5 February 2020

publication date

22 June 2011

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5 February 2020

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5 February 2020

volume

8

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5 February 2020

page(s)

50

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Dynamic interplay between viral adaptation and immune recognition during HIV-1 infection

5 February 2020

cites work

1 reference

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Dys-regulated activation of a Src tyroine kinase Hck at the Golgi disturbs N-glycosylation of a cytokine receptor Fms.

29 May 2018

1 reference

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Differential HIV epitope processing in monocytes and CD4 T cells affects cytotoxic T lymphocyte recognition

29 May 2018

1 reference

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Evidence of CD8+ T-cell-mediated selective pressure on human immunodeficiency virus type 1 nef in HLA-B*57+ elite suppressors

29 May 2018

1 reference

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Characterization of the follicular dendritic cell reservoir of human immunodeficiency virus type 1.

29 May 2018

1 reference

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Structural and functional constraints limit options for cytotoxic T-lymphocyte escape in the immunodominant HLA-B27-restricted epitope in human immunodeficiency virus type 1 capsid

29 May 2018

1 reference

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Escape and compensation from early HLA-B57-mediated cytotoxic T-lymphocyte pressure on human immunodeficiency virus type 1 Gag alter capsid interactions with cyclophilin A.

29 May 2018

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Evidence of differential HLA class I-mediated viral evolution in functional and accessory/regulatory genes of HIV-1

29 May 2018

1 reference

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In vitro modeling of the HIV-macrophage reservoir

29 May 2018

1 reference

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HIV-1 Nef selectively activates Src family kinases Hck, Lyn, and c-Src through direct SH3 domain interaction

29 May 2018

1 reference

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Impact of Nef-mediated downregulation of major histocompatibility complex class I on immune response to simian immunodeficiency virus

29 May 2018

1 reference

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HIV and SIV CTL escape: implications for vaccine design

29 May 2018

1 reference

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Proline 78 is crucial for human immunodeficiency virus type 1 Nef to down-regulate class I human leukocyte antigen

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3131245

Long-term survival and virus production in human primary macrophages infected by human immunodeficiency virus

29 May 2018

1 reference

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Evidence for human immunodeficiency virus type 1 replication in vivo in CD14(+) monocytes and its potential role as a source of virus in patients on highly active antiretroviral therapy

29 May 2018

1 reference

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A natural variability in the proline-rich motif of Nef modulates HIV-1 replication in primary T cells.

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3131245

Nef-induced major histocompatibility complex class I down-regulation is functionally dissociated from its virion incorporation, enhancement of viral infectivity, and CD4 down-regulation

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3131245

SH3-mediated Hck tyrosine kinase activation and fibroblast transformation by the Nef protein of HIV-1.

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3131245

The human immunodeficiency virus-1 nef gene product: a positive factor for viral infection and replication in primary lymphocytes and macrophages

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3131245

Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3131245

Virus-specific CD8+ cytotoxic T-lymphocyte activity associated with control of viremia in primary human immunodeficiency virus type 1 infection

29 May 2018

1 reference

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Proline-rich (PxxP) motifs in HIV-1 Nef bind to SH3 domains of a subset of Src kinases and are required for the enhanced growth of Nef+ viruses but not for down-regulation of CD4

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3131245

Impact of intrinsic cooperative thermodynamics of peptide-MHC complexes on antiviral activity of HIV-specific CTL.

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3131245

Altering effects of antigenic variations in HIV-1 on antiviral effectiveness of HIV-specific CTLs.

17 August 2018

1 reference

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HIV-1-specific CTLs effectively suppress replication of HIV-1 in HIV-1-infected macrophages.

17 August 2018

1 reference

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HIV-1 actively replicates in naive CD4(+) T cells residing within human lymphoid tissues

17 August 2018

1 reference

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HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes.

17 August 2018

1 reference

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Quantitation of HIV-1-Specific Cytotoxic T Lymphocytes and Plasma Load of Viral RNA

17 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.1186%2F1742-4690-8-50

CTL-Mediated Selective Pressure Influences Dynamic Evolution and Pathogenic Functions of HIV-1 Nef

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21696586

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1186/1742-4690-8-50

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21696586%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

5 February 2020

0 references

1 reference

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5 February 2020

PubMed publication ID

21696586

1 reference