Microfluidic cell culture and its application in high-throughput drug screening: cardiotoxicity assay for hERG channels (Q42078619)

16 October 2017

Microfluidic cell culture and its application in high-throughput drug screening: cardiotoxicity assay for hERG channels (English)

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16 October 2017

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Timothy J Kamp

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David J Beebe

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object named as

David J Beebe

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16 October 2017

Xiaojing Su

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16 October 2017

Edmond W K Young

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16 October 2017

Heather A S Underkofler

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16 October 2017

Craig T January

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16 October 2017

language of work or name

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3 December 2010

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Journal of Biomolecular Screening

16 October 2017

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16 October 2017

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16 October 2017

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16 October 2017

101-111

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Rapid Prototyping of Microfluidic Systems in Poly(dimethylsiloxane).

16 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3052261

Expanding the available assays: adapting and validating In-Cell Westerns in microfluidic devices for cell-based assays

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3052261

A microfluidic approach for anticancer drug analysis based on hydrogel encapsulated tumor cells

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3052261

Automated high-throughput microchannel assays for cell biology: Operational optimization and characterization

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3052261

Fundamentals of microfluidic cell culture in controlled microenvironments

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3052261

Trends in risks associated with new drug development: success rates for investigational drugs

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3052261

Technique for real-time measurements of endothelial permeability in a microfluidic membrane chip using laser-induced fluorescence detection

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3052261

From the cellular perspective: exploring differences in the cellular baseline in macroscale and microfluidic cultures

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3052261

Cellular observations enabled by microculture: paracrine signaling and population demographics

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3052261

Integrated microfluidic chip for endothelial cells culture and analysis exposed to a pulsatile and oscillatory shear stress

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3052261

Biological implications of polydimethylsiloxane-based microfluidic cell culture

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3052261

Microfluidic endothelium for studying the intravascular adhesion of metastatic breast cancer cells

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3052261

Small GTPase determinants for the Golgi processing and plasmalemmal expression of human ether-a-go-go related (hERG) K+ channels

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3052261

Microfluidics meet cell biology: bridging the gap by validation and application of microscale techniques for cell biological assays

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3052261

The hERG potassium channel and hERG screening for drug-induced torsades de pointes

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3052261

Automated cell culture in high density tubeless microfluidic device arrays

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3052261

Versatile, fully automated, microfluidic cell culture system

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3052261

Drug-induced long QT syndrome: hERG K+ channel block and disruption of protein trafficking by fluoxetine and norfluoxetine.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3052261

hERG potassium channels and cardiac arrhythmia

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3052261

HERG-Lite: a novel comprehensive high-throughput screen for drug-induced hERG risk

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3052261

Identifying modulators of hERG channel activity using the PatchXpress planar patch clamp

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3052261

Nonradioactive rubidium ion efflux assay and its applications in drug discovery and development

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3052261

Acquired QT interval prolongation and HERG: implications for drug discovery and development

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3052261

Inhibition of hERG K+ currents by antimalarial drugs in stably transfected HEK293 cells.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3052261

The price of innovation: new estimates of drug development costs

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3052261

A comparison of the receptor binding and HERG channel affinities for a series of antipsychotic drugs

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3052261

[3H]dofetilide binding to HERG transfected membranes: a potential high throughput preclinical screen.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3052261

Block of HERG potassium channels by the antihistamine astemizole and its metabolites desmethylastemizole and norastemizole

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3052261

HERG channel dysfunction in human long QT syndrome. Intracellular transport and functional defects

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3052261

Properties of HERG channels stably expressed in HEK 293 cells studied at physiological temperature

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3052261

High affinity open channel block by dofetilide of HERG expressed in a human cell line.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3052261

The future of drug development: advancing clinical trial design.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3052261

Matrix-dependent adhesion of vascular and valvular endothelial cells in microfluidic channels.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3052261

Flow rate analysis of a surface tension driven passive micropump.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3052261

PDMS absorption of small molecules and consequences in microfluidic applications.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3052261

The phenothiazine drugs inhibit hERG potassium channels

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3052261

Population pharmacokinetic modeling of blood-brain barrier transport of synthetic adenosine A1 receptor agonists

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3052261

Mechanisms of arsenic-induced prolongation of cardiac repolarization

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3052261

A passive pumping method for microfluidic devices.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3052261

Drug block of I(kr): model systems and relevance to human arrhythmias

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3052261

A microfluidic wound-healing assay for quantifying endothelial cell migration

17 August 2018

1 reference

12 December 2020

Spending on new drug development1

1 reference

12 December 2020

A high-throughput HERG potassium channel function assay: an old assay with a new look

1 reference

12 December 2020

Screening lead compounds for QT interval prolongation

1 reference

12 December 2020

Identifiers

DOI

10.1177/1087057110386218

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16 October 2017

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16 October 2017

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