Nanog homeobox (Q420522)

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transcriptional factor that helps embryonic stem cells maintain pluripotency by suppressing cell determination factors

hNanog
homeobox transcription factor Nanog-delta 48
NANOG
homeobox protein NANOG
homeobox transcription factor Nanog
Nanog Homeobox Protein

Language	Label	Description	Also known as
English	Nanog homeobox	transcriptional factor that helps embryonic stem cells maintain pluripotency by suppressing cell determination factors	hNanog homeobox transcription factor Nanog-delta 48 NANOG homeobox protein NANOG homeobox transcription factor Nanog Nanog Homeobox Protein

Statements

1 reference

13 November 2019

UniProt protein ID

Homeobox-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9H9S0

Homeobox domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Homeobox, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

DNA-binding transcription factor activity

determination method

1 reference

7 November 2018

Core transcriptional regulatory circuitry in human embryonic stem cells

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H9S0&geneProductId=UniProtKB:Q9H9S0

determination method

determination method

4 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H9S0

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H9S0

determination method

8 April 2019

Purification of human transcription factors Nanog and Sox2, each in complex with Skp, an Escherichia coli periplasmic chaperone

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H9S0

determination method

8 April 2019

Core transcriptional regulatory circuitry in human embryonic stem cells

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H9S0

determination method

sequence-specific DNA binding

determination method

1 reference

7 November 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H9S0&geneProductId=UniProtKB:Q9H9S0

determination method

protein binding

determination method

1 reference

8 April 2019

The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H9S0

determination method

transcription corepressor activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H9S0

determination method

RNA polymerase II transcription regulatory region sequence-specific DNA binding

determination method

1 reference

8 April 2019

Phosphorylation of Nanog is essential to regulate Bmi1 and promote tumorigenesis

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H9S0

determination method

DNA-binding transcription activator activity, RNA polymerase II-specific

determination method

1 reference

8 April 2019

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H9S0

determination method

DNA-binding transcription factor activity, RNA polymerase II-specific

determination method

3 references

8 April 2019

A census of human transcription factors: function, expression and evolution

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H9S0

determination method

8 April 2019

A census of human transcription factors: function, expression and evolution

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H9S0

determination method

8 April 2019

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H9S0

determination method

RNA polymerase II cis-regulatory region sequence-specific DNA binding

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H9S0

determination method

determination method

1 reference

8 April 2019

Expression profile of the embryonic markers nanog, OCT-4, SSEA-1, SSEA-4, and frizzled-9 receptor in human periodontal ligament mesenchymal stem cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H9S0

determination method

determination method

3 references

7 November 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H9S0&geneProductId=UniProtKB:Q9H9S0

determination method

7 November 2018

Differentiation of human embryonic stem cells into osteogenic or hematopoietic lineages: a dose-dependent effect of osterix over-expression

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H9S0&geneProductId=UniProtKB:Q9H9S0

determination method

7 November 2018

Core transcriptional regulatory circuitry in human embryonic stem cells

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H9S0&geneProductId=UniProtKB:Q9H9S0

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H9S0

determination method

determination method

4 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H9S0

determination method

8 April 2019

Differentiation of human embryonic stem cells into osteogenic or hematopoietic lineages: a dose-dependent effect of osterix over-expression

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H9S0

determination method

8 April 2019

Core transcriptional regulatory circuitry in human embryonic stem cells

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H9S0

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H9S0

determination method

biological process

regulation of gene expression

determination method

1 reference

8 April 2019

Regulation of self-renewal and pluripotency by Sox2 in human embryonic stem cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H9S0

determination method

regulation of cell differentiation

determination method

1 reference

8 April 2019

Overexpression of NANOG in human ES cells enables feeder-free growth while inducing primitive ectoderm features

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H9S0

determination method

multicellular organism development

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H9S0

determination method

cell differentiation

determination method

1 reference

8 April 2019

Overexpression of NANOG in human ES cells enables feeder-free growth while inducing primitive ectoderm features

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H9S0

determination method

cell population proliferation

determination method

1 reference

7 November 2018

Overexpression of NANOG in human ES cells enables feeder-free growth while inducing primitive ectoderm features

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H9S0&geneProductId=UniProtKB:Q9H9S0

determination method

transcription, DNA-templated

determination method

1 reference

27 March 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H9S0&geneProductId=UniProtKB:Q9H9S0

determination method

positive regulation of transcription by RNA polymerase II

determination method

1 reference

8 April 2019

Foxp1 coordinates cardiomyocyte proliferation through both cell-autonomous and nonautonomous mechanisms

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H9S0

determination method

endodermal cell fate specification

determination method

1 reference

8 April 2019

Foxp1 coordinates cardiomyocyte proliferation through both cell-autonomous and nonautonomous mechanisms

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H9S0

determination method

negative regulation of nucleic acid-templated transcription

determination method

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H9S0

determination method

transcription by RNA polymerase II

determination method

1 reference

27 March 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9H9S0&geneProductId=UniProtKB:Q9H9S0

determination method

cytokine-mediated signaling pathway

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H9S0

determination method

regulation of transcription by RNA polymerase II

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H9S0

determination method

positive regulation of stem cell proliferation

determination method

1 reference

8 April 2019

Overexpression of NANOG in human ES cells enables feeder-free growth while inducing primitive ectoderm features

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9H9S0

determination method

Gene Atlas image

PBB GE NANOG 220184 at fs.png
732 × 530; 12 KB

0 references

http://purl.uniprot.org/uniprot/Q9H9S0

1 reference

Identifiers.org

Homeobox, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9H9S0

Homeobox domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9H9S0

Identifiers

MeSH descriptor ID

subject named as

Nanog Homeobox Protein

0 references

D12.776.260.400.530

0 references

D12.776.930.542

0 references

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000229307

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000229307

ENSP00000435288

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000435288

ENSP00000444434

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000444434

1 reference

Freebase Data Dumps

publication date

28 October 2013

Microsoft Academic ID

0 references

0 references

1 reference

26 January 2022

https://docs.openalex.org/download-snapshot/snapshot-data-format

1 reference

26 January 2022

https://docs.openalex.org/download-snapshot/snapshot-data-format

PDB structure ID

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

based on heuristic

inferred by common MeSH mappings on source and on Wikidata

25 May 2023

Sitelinks

Wikipedia(10 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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