Neurolysosomal pathology in human prosaposin deficiency suggests essential neurotrophic function of prosaposin (Q42003817)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17024494%20AND%20SRC:MED&resulttype=core&format=json

20 December 2019

title

Neurolysosomal pathology in human prosaposin deficiency suggests essential neurotrophic function of prosaposin (English)

1 reference

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encephalopathy due to prosaposin deficiency

20 December 2019

main subject

pathology

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1 reference

1

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20 December 2019

author name string

Klaus Harzer

series ordinal

2

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20 December 2019

Milan Elleder

series ordinal

3

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20 December 2019

publication date

6 October 2006

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20 December 2019

published in

Acta Neuropathologica

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20 December 2019

volume

113

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20 December 2019

issue

2

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20 December 2019

page(s)

163-175

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describes a project that uses

20 December 2019

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2956888/fullTextXML

inferred from PubMed Central ID database lookup

exact match

https://scigraph.springernature.com/pub.10.1007/s00401-006-0148-7

0 references

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Prosaptide activates the MAPK pathway by a G-protein-dependent mechanism essential for enhanced sulfatide synthesis by Schwann cells.

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Cell death prevention, mitogen-activated protein kinase stimulation, and increased sulfatide concentrations in Schwann cells and oligodendrocytes by prosaposin and prosaptides

5 June 2018

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A hydrophilic peptide comprising 18 amino acid residues of the prosaposin sequence has neurotrophic activity in vitro and in vivo.

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5 June 2018

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Identification of prosaposin as a neurotrophic factor

5 June 2018

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5 June 2018

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5 June 2018

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5 June 2018

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5 June 2018

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5 June 2018

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5 June 2018

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5 June 2018

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5 June 2018

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5 June 2018

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17 August 2018

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17 August 2018

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17 August 2018

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A novel mutation in the coding region of the prosaposin gene leads to a complete deficiency of prosaposin and saposins, and is associated with a complex sphingolipidosis dominated by lactosylceramide accumulation

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2956888

Administration of prosaposin ameliorates spatial learning disturbance and reduces cavity formation following stab wounds in rat brain.

17 August 2018

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17 August 2018

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17 August 2018

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17 August 2018

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17 August 2018

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Occurrence of prosaposin as a neuronal surface membrane component.

17 August 2018

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Identification of the neurotrophic factor sequence of prosaposin

17 August 2018

1 reference

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17 August 2018

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12 December 2020

Prosaposin deficiency: further characterization of the sphingolipid activator protein-deficient sibs. Multiple glycolipid elevations (including lactosylceramidosis), partial enzyme deficiencies and ultrastructure of the skin in this generalized sphi

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12 December 2020

Niemann-Pick disease type C with enhanced glycolipid storage

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12 December 2020

Promoting motor neuron survival

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12 December 2020

A histochemical and ultrastructural study of stored material in neuronal ceroid lipofuscinosis

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12 December 2020

Production and characterization of monoclonal antibodies specific to multi-ubiquitin chains of polyubiquitinated proteins

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12 December 2020

Neuronal ubiquitin and neurofilament expression in different lysosomal storage disorders

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12 December 2020

Immunostaining for ubiquitin: efficient pretreatment

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12 December 2020

Prosaposin facilitates sciatic nerve regeneration in vivo

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12 December 2020

Colocalization and complex formation between prosaposin and monosialoganglioside GM3 in neural cells

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12 December 2020

Immunogold localisation of ubiquitin-protein conjugates in primary (azurophilic) granules of polymorphonuclear neutrophils

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12 December 2020

Ubiquitin and the control of protein fate in the secretory and endocytic pathways

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12 December 2020

10.1007/S00401-006-0148-7

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17024494%20AND%20SRC:MED&resulttype=core&format=json

20 December 2019

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17024494%20AND%20SRC:MED&resulttype=core&format=json

20 December 2019

1 reference