Proteolytic activation of the porcine epidemic diarrhea coronavirus spike fusion protein by trypsin in cell culture (Q41975503)

14 October 2017

Proteolytic activation of the porcine epidemic diarrhea coronavirus spike fusion protein by trypsin in cell culture (English)

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Frank J. M. van Kuppeveld

14 October 2017

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object named as

Frank J M van Kuppeveld

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14 October 2017

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Peter J M Rottier

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14 October 2017

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Berend Jan Bosch

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14 October 2017

Oliver Wicht

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14 October 2017

Wentao Li

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14 October 2017

Lione Willems

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14 October 2017

Tom J Meuleman

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14 October 2017

Richard W Wubbolts

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14 October 2017

language of work or name

English

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publication date

7 May 2014

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14 October 2017

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14 October 2017

88

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14 October 2017

14

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14 October 2017

7952-7961

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describes a project that uses

14 October 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4097775/fullTextXML

inferred from PubMed Central ID database lookup

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Proteolytic activation of the SARS-coronavirus spike protein: cutting enzymes at the cutting edge of antiviral research.

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Manipulation of the porcine epidemic diarrhea virus genome using targeted RNA recombination

5 June 2018

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Mutation in spike protein cleavage site and pathogenesis of feline coronavirus

5 June 2018

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Host cell entry of respiratory syncytial virus involves macropinocytosis followed by proteolytic activation of the F protein

5 June 2018

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TMPRSS2 activates the human coronavirus 229E for cathepsin-independent host cell entry and is expressed in viral target cells in the respiratory epithelium

5 June 2018

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5 June 2018

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Characterization of cellular furin content as a potential factor determining the susceptibility of cultured human and animal cells to coronavirus infectious bronchitis virus infection

5 June 2018

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5 June 2018

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5 June 2018

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Mechanisms of coronavirus cell entry mediated by the viral spike protein

5 June 2018

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Influenza and SARS-coronavirus activating proteases TMPRSS2 and HAT are expressed at multiple sites in human respiratory and gastrointestinal tracts

5 June 2018

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Mutation in the cytoplasmic retrieval signal of porcine epidemic diarrhea virus spike (S) protein is responsible for enhanced fusion activity

5 June 2018

1 reference

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Role of host cellular proteases in the pathogenesis of influenza and influenza-induced multiple organ failure

5 June 2018

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Role of proteases in the release of porcine epidemic diarrhea virus from infected cells

5 June 2018

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Efficient activation of the severe acute respiratory syndrome coronavirus spike protein by the transmembrane protease TMPRSS2.

5 June 2018

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5 June 2018

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Two-step conformational changes in a coronavirus envelope glycoprotein mediated by receptor binding and proteolysis

5 June 2018

1 reference

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Host envelope glycoprotein processing proteases are indispensable for entry into human cells by seasonal and highly pathogenic avian influenza viruses

5 June 2018

1 reference

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Proteolytic activation of the spike protein at a novel RRRR/S motif is implicated in furin-dependent entry, syncytium formation, and infectivity of coronavirus infectious bronchitis virus in cultured cells

5 June 2018

1 reference

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Characterization of a highly conserved domain within the severe acute respiratory syndrome coronavirus spike protein S2 domain with characteristics of a viral fusion peptide

5 June 2018

1 reference

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Activation of the SARS coronavirus spike protein via sequential proteolytic cleavage at two distinct sites

5 June 2018

1 reference

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Protease-mediated entry via the endosome of human coronavirus 229E.

5 June 2018

1 reference

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Entry from the cell surface of severe acute respiratory syndrome coronavirus with cleaved S protein as revealed by pseudotype virus bearing cleaved S protein.

5 June 2018

1 reference

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5 June 2018

Viral membrane fusion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097775

Structures and Mechanisms of Viral Membrane Fusion Proteins: Multiple Variations on a Common Theme

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097775

Cloning and further sequence analysis of the ORF3 gene of wild- and attenuated-type porcine epidemic diarrhea viruses

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097775

Porcine aminopeptidase N is a functional receptor for the PEDV coronavirus.

5 June 2018

1 reference

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Sequence analysis of the partial spike glycoprotein gene of porcine epidemic diarrhea viruses isolated in Korea

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097775

Proteolytic activation of influenza viruses by serine proteases TMPRSS2 and HAT from human airway epithelium

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097775

Endosomal proteolysis by cathepsins is necessary for murine coronavirus mouse hepatitis virus type 2 spike-mediated entry

5 June 2018

1 reference

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SARS coronavirus, but not human coronavirus NL63, utilizes cathepsin L to infect ACE2-expressing cells

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097775

Inhibitors of cathepsin L prevent severe acute respiratory syndrome coronavirus entry

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097775

The Coronavirus Spike Protein Is a Class I Virus Fusion Protein: Structural and Functional Characterization of the Fusion Core Complex

5 June 2018

1 reference

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Receptor-induced conformational changes of murine coronavirus spike protein

5 June 2018

1 reference

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A murine and a porcine coronavirus are released from opposite surfaces of the same epithelial cells.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097775

Sequence analysis of the porcine epidemic diarrhea virus genome between the nucleocapsid and spike protein genes reveals a polymorphic ORF.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097775

Impairment of multicycle influenza virus growth in Vero (WHO) cells by loss of trypsin activity.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097775

Characterization of the structural proteins of porcine epizootic diarrhea virus, strain CV777.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097775

Proteolytic cleavage of the E2 glycoprotein of murine coronavirus: host-dependent differences in proteolytic cleavage and cell fusion.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097775

Propagation of the virus of porcine epidemic diarrhea in cell culture

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097775

A new coronavirus-like particle associated with diarrhea in swine

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097775

Receptor-bound porcine epidemic diarrhea virus spike protein cleaved by trypsin induces membrane fusion

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097775

Mutations in the spike gene of porcine epidemic diarrhea virus associated with growth adaptation in vitro and attenuation of virulence in vivo

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097775

Cloning and further sequence analysis of the spike gene of attenuated porcine epidemic diarrhea virus DR13.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097775

The SARS-CoV S glycoprotein: expression and functional characterization

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097775

Differentiation of a Vero cell adapted porcine epidemic diarrhea virus from Korean field strains by restriction fragment length polymorphism analysis of ORF 3

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097775

Derivation of attenuated porcine epidemic diarrhea virus (PEDV) as vaccine candidate

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4097775

Coronavirus IBV: structural characterization of the spike protein

18 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24807723

12 December 2020

inferred from PubMed ID database lookup

Type II transmembrane serine proteases

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24807723

12 December 2020

inferred from PubMed ID database lookup

Endoproteolytic cleavage of HIV-1 gp160 envelope precursor occurs after exit from the trans-Golgi network (TGN)

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24807723

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1128/JVI.00297-14

1 reference

14 October 2017

1 reference

14 October 2017

PubMed publication ID

24807723

1 reference