Mutations in TSC1, TSC2, and MTOR Are Associated with Response to Rapalogs in Patients with Metastatic Renal Cell Carcinoma (Q41975337)

14 October 2017

Mutations in TSC1, TSC2, and MTOR Are Associated with Response to Rapalogs in Patients with Metastatic Renal Cell Carcinoma (English)

1 reference

metastatic renal cell carcinoma

14 October 2017

1 reference

6

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11 June 2020

Thai Huu Ho

11

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11 June 2020

9

Laurence Albiges

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11 June 2020

2

Toni K Choueiri

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11 June 2020

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Sabina Signoretti

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11 June 2020

author name string

David J Kwiatkowski

1

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11 June 2020

André P Fay

3

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11 June 2020

Brian I Rini

4

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11 June 2020

Aaron R Thorner

5

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11 June 2020

Magdalena E Tyburczy

7

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11 June 2020

Lana Hamieh

8

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11 June 2020

Neeraj Agarwal

10

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11 June 2020

Jiaxi Song

12

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11 June 2020

Jean-Christophe Pignon

13

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11 June 2020

Pablo M Barrios

14

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11 June 2020

M Dror Michaelson

15

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11 June 2020

Eliezer Van Allen

16

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11 June 2020

Katherine M Krajewski

17

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11 June 2020

Camillo Porta

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11 June 2020

Sumanta Pal

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11 June 2020

Joaquim Bellmunt

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11 June 2020

David F McDermott

21

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11 June 2020

Daniel Y C Heng

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11 June 2020

Kathryn P Gray

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11 June 2020

language of work or name

English

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publication date

1 February 2016

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14 October 2017

Clinical Cancer Research

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11 June 2020

volume

22

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11 June 2020

page(s)

2445-2452

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11 June 2020

issue

10

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Regulation of mTORC1 by PI3K signaling

11 June 2020

cites work

1 reference

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5 June 2018

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Coordinated regulation of protein synthesis and degradation by mTORC1

5 June 2018

1 reference

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A diverse array of cancer-associated MTOR mutations are hyperactivating and can predict rapamycin sensitivity.

5 June 2018

1 reference

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Activating mTOR mutations in a patient with an extraordinary response on a phase I trial of everolimus and pazopanib

5 June 2018

1 reference

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Tumor genetic analyses of patients with metastatic renal cell carcinoma and extended benefit from mTOR inhibitor therapy

5 June 2018

1 reference

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Rapamycin: one drug, many effects

5 June 2018

1 reference

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Discovery and saturation analysis of cancer genes across 21 tumour types

5 June 2018

1 reference

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mTORC1 phosphorylation sites encode their sensitivity to starvation and rapamycin

5 June 2018

1 reference

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Comprehensive molecular characterization of clear cell renal cell carcinoma

5 June 2018

1 reference

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Mutations in Hedgehog pathway genes in fetal rhabdomyomas

5 June 2018

1 reference

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Signal integration by mTORC1 coordinates nutrient input with biosynthetic output.

5 June 2018

1 reference

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A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1

5 June 2018

1 reference

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Equivalent benefit of rapamycin and a potent mTOR ATP-competitive inhibitor, MLN0128 (INK128), in a mouse model of tuberous sclerosis

5 June 2018

1 reference

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Extrarenal perivascular epithelioid cell tumors (PEComas) respond to mTOR inhibition: clinical and molecular correlates

5 June 2018

1 reference

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Genome sequencing identifies a basis for everolimus sensitivity

5 June 2018

1 reference

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The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data

5 June 2018

1 reference

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Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

5 June 2018

1 reference

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Summarizing and correcting the GC content bias in high-throughput sequencing

5 June 2018

1 reference

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Interplay between pVHL and mTORC1 pathways in clear-cell renal cell carcinoma.

5 June 2018

1 reference

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A framework for variation discovery and genotyping using next-generation DNA sequencing data

5 June 2018

1 reference

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5 June 2018

1 reference

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The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data

5 June 2018

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Phase 3 trial of everolimus for metastatic renal cell carcinoma : final results and analysis of prognostic factors

5 June 2018

1 reference

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A method and server for predicting damaging missense mutations

5 June 2018

1 reference

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Fast and accurate long-read alignment with Burrows-Wheeler transform

5 June 2018

1 reference

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Clinical activity of mTOR inhibition with sirolimus in malignant perivascular epithelioid cell tumors: targeting the pathogenic activation of mTORC1 in tumors

5 June 2018

1 reference

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TSC1 loss synergizes with KRAS activation in lung cancer development in the mouse and confers rapamycin sensitivity.

5 June 2018

1 reference

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Common corruption of the mTOR signaling network in human tumors

5 June 2018

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5 June 2018

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Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled phase III trial

5 June 2018

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The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1

5 June 2018

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5 June 2018

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Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis

5 June 2018

1 reference

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Circular binary segmentation for the analysis of array-based DNA copy number data

5 June 2018

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EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy

5 June 2018

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Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb

5 June 2018

1 reference

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Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

5 June 2018

1 reference

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Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4976069

Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4976069

Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4976069

Predicting deleterious amino acid substitutions

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4976069

Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism

5 June 2018

1 reference

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A mammalian protein targeted by G1-arresting rapamycin-receptor complex

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4976069

10.1158/1078-0432.CCR-15-2631

5 June 2018

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26831717%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

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11 June 2020

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