Stability of transmembrane amyloid β-peptide and membrane integrity tested by molecular modeling of site-specific Aβ42 mutations. (Q41970717)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24244308%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

title

Stability of transmembrane amyloid β-peptide and membrane integrity tested by molecular modeling of site-specific Aβ42 mutations (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24244308%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

main subject

transmembrane protein

0 references

author

Chetan S Poojari

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24244308%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

Birgit Strodel

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24244308%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

author name string

Chetan Poojari

1

1 reference

14 October 2017

Birgit Strodel

2

1 reference

14 October 2017

language of work or name

English

0 references

publication date

7 November 2013

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24244308%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24244308%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

volume

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24244308%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

issue

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24244308%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

page(s)

e78399

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24244308%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution 4.0 International

1 March 2020

copyright license

start time

7 November 2013

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

describes a project that uses

1 reference

GROMACS 4: Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation

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Lipid Models for United-Atom Molecular Dynamics Simulations of Proteins.

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How the amyloid-β peptide and membranes affect each other: an extensive simulation study

5 June 2018

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Are Protein Force Fields Getting Better? A Systematic Benchmark on 524 Diverse NMR Measurements

5 June 2018

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Probing structural features of Alzheimer's amyloid-β pores in bilayers using site-specific amino acid substitutions

5 June 2018

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Amphiphilic adsorption of human islet amyloid polypeptide aggregates to lipid/aqueous interfaces

5 June 2018

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Polymorphism of amyloid β peptide in different environments: implications for membrane insertion and pore formation

5 June 2018

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Aggregation of amyloids in a cellular context: modelling and experiment

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Membrane and surface interactions of Alzheimer's Aβ peptide--insights into the mechanism of cytotoxicity

5 June 2018

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Lipid composition influences the release of Alzheimer's amyloid β-peptide from membranes.

5 June 2018

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Antimicrobial protegrin-1 forms amyloid-like fibrils with rapid kinetics suggesting a functional link

5 June 2018

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Point mutations in Aβ result in the formation of distinct polymorphic aggregates in the presence of lipid bilayers

5 June 2018

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Toward a molecular theory of early and late events in monomer to amyloid fibril formation

5 June 2018

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Models of membrane-bound Alzheimer's Abeta peptide assemblies

5 June 2018

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Transmembrane structures for Alzheimer's Aβ(1-42) oligomers.

5 June 2018

1 reference

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Synaptotoxicity of Alzheimer beta amyloid can be explained by its membrane perforating property

5 June 2018

1 reference

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A molecular dynamics study of the early stages of amyloid-beta(1-42) oligomerization: the role of lipid membranes

5 June 2018

1 reference

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Antimicrobial protegrin-1 forms ion channels: molecular dynamic simulation, atomic force microscopy, and electrical conductance studies

5 June 2018

1 reference

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Lipid membranes and beta-amyloid: a harmful connection

5 June 2018

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Structures of beta-amyloid peptide 1-40, 1-42, and 1-55-the 672-726 fragment of APP-in a membrane environment with implications for interactions with gamma-secretase

5 June 2018

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Misfolded amyloid ion channels present mobile beta-sheet subunits in contrast to conventional ion channels

5 June 2018

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Secondary structure propensities in peptide folding simulations: a systematic comparison of molecular mechanics interaction schemes

5 June 2018

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Interaction between amyloid-beta (1-42) peptide and phospholipid bilayers: a molecular dynamics study

5 June 2018

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Amyloid precursor protein trafficking, processing, and function

5 June 2018

1 reference

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Effects of familial Alzheimer's disease mutations on the folding nucleation of the amyloid beta-protein

5 June 2018

1 reference

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Structures and free-energy landscapes of the wild type and mutants of the Abeta(21-30) peptide are determined by an interplay between intrapeptide electrostatic and hydrophobic interactions

5 June 2018

1 reference

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Are current molecular dynamics force fields too helical?

5 June 2018

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Distribution of amino acids in a lipid bilayer from computer simulations.

5 June 2018

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New structures help the modeling of toxic amyloidbeta ion channels

5 June 2018

1 reference

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Systematic in vivo analysis of the intrinsic determinants of amyloid Beta pathogenicity

5 June 2018

1 reference

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Familial Alzheimer's disease mutations alter the stability of the amyloid beta-protein monomer folding nucleus

5 June 2018

1 reference

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Molecular dynamics simulations of rhodopsin in different one-component lipid bilayers.

5 June 2018

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Models of beta-amyloid ion channels in the membrane suggest that channel formation in the bilayer is a dynamic process

5 June 2018

1 reference

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The Arctic Alzheimer mutation favors intracellular amyloid-beta production by making amyloid precursor protein less available to alpha-secretase

5 June 2018

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Setting up and running molecular dynamics simulations of membrane proteins

5 June 2018

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A beta oligomers - a decade of discovery

5 June 2018

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Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide

5 June 2018

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Canonical sampling through velocity rescaling

5 June 2018

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100 years and counting: prospects for defeating Alzheimer's disease

5 June 2018

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5 June 2018

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Experimental constraints on quaternary structure in Alzheimer's beta-amyloid fibrils

5 June 2018

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3D structure of Alzheimer's amyloid-beta(1-42) fibrils

5 June 2018

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Amyloid ion channels: a common structural link for protein-misfolding disease

5 June 2018

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Conformational transition of amyloid beta-peptide

5 June 2018

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Surface behavior and lipid interaction of Alzheimer beta-amyloid peptide 1-42: a membrane-disrupting peptide

5 June 2018

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In silico study of amyloid beta-protein folding and oligomerization

5 June 2018

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A biomolecular force field based on the free enthalpy of hydration and solvation: the GROMOS force-field parameter sets 53A5 and 53A6

5 June 2018

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Novel amyloid precursor protein gene missense mutation (D678N) in probable familial Alzheimer's disease

5 June 2018

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Stabilities and conformations of Alzheimer's beta -amyloid peptide oligomers (Abeta 16-22, Abeta 16-35, and Abeta 10-35): Sequence effects

5 June 2018

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Paradigm shifts in Alzheimer's disease and other neurodegenerative disorders: the emerging role of oligomeric assemblies

5 June 2018

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Long time dynamic simulations: exploring the folding pathways of an Alzheimer's amyloid Abeta-peptide

5 June 2018

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Amyloid beta protein forms ion channels: implications for Alzheimer's disease pathophysiology

5 June 2018

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The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Abeta protofibril formation

5 June 2018

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In vitro studies of amyloid beta-protein fibril assembly and toxicity provide clues to the aetiology of Flemish variant (Ala692-->Gly) Alzheimer's disease

5 June 2018

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Amyloid beta protein (1-40) forms calcium-permeable, Zn2+-sensitive channel in reconstituted lipid vesicles

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Canonical dynamics: Equilibrium phase-space distributions

5 June 2018

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The role of A beta 42 in Alzheimer's disease

5 June 2018

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5 June 2018

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The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease

5 June 2018

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5 June 2018

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5 June 2018

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5 June 2018

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5 June 2018

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Aggregation of Alzheimer's amyloid β-peptide in biological membranes: a molecular dynamics study

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Molecular dynamics simulations of low-ordered alzheimer β-amyloid oligomers from dimer to hexamer on self-assembled monolayers.

18 August 2018

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18 August 2018

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18 August 2018

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A comparative molecular dynamics analysis of the amyloid beta-peptide in a lipid bilayer.

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Permeabilization of lipid bilayers is a common conformation-dependent activity of soluble amyloid oligomers in protein misfolding diseases

18 August 2018

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Architecture of the Alzheimer's A beta P ion channel pore

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Neurotoxicity and physicochemical properties of Abeta mutant peptides from cerebral amyloid angiopathy: implication for the pathogenesis of cerebral amyloid angiopathy and Alzheimer's disease

18 August 2018

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Early onset familial Alzheimer's disease: Mutation frequency in 31 families.

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Novel amyloid precursor protein mutation in an Iowa family with dementia and severe cerebral amyloid angiopathy

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Substitutions at codon 22 of Alzheimer's abeta peptide induce diverse conformational changes and apoptotic effects in human cerebral endothelial cells.

18 August 2018

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The origins of Alzheimer disease: a is for amyloid.

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Protofibrillar intermediates of amyloid beta-protein induce acute electrophysiological changes and progressive neurotoxicity in cortical neurons.

18 August 2018

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Distribution and fluidizing action of soluble and aggregated amyloid beta-peptide in rat synaptic plasma membranes.

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Amyloid beta-protein fibrillogenesis. Detection of a protofibrillar intermediate.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820573

Aggregation and metal-binding properties of mutant forms of the amyloid A beta peptide of Alzheimer's disease.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820573

Particle mesh Ewald: An N⋅log(N) method for Ewald sums in large systems

18 August 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0078399

Amyloid beta protein precursor gene and hereditary cerebral hemorrhage with amyloidosis (Dutch)

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0078399

β-Sheet Structured β-Amyloid(1-40) Perturbs Phosphatidylcholine Model Membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0078399

Lysozyme Amyloid Oligomers and Fibrils Induce Cellular Death via Different Apoptotic/Necrotic Pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0078399

Amyloid beta-protein fibrillogenesis. Structure and biological activity of protofibrillar intermediates

21 January 2018

1 reference

12 December 2020

Protofibrillar islet amyloid polypeptide permeabilizes synthetic vesicles by a pore-like mechanism that may be relevant to type II diabetes

1 reference

12 December 2020

Interaction of Alzheimer beta-amyloid peptide(1-40) with lipid membranes

1 reference

12 December 2020

Solution conformations and aggregational properties of synthetic amyloid beta-peptides of Alzheimer's disease. Analysis of circular dichroism spectra

1 reference

12 December 2020

Structure of the amyloid-beta (1-42) monomer absorbed to model phospholipid bilayers: a molecular dynamics study

1 reference

12 December 2020

Structures of the Amyloid β-Peptides Aβ1–40 and Aβ1–42 as Influenced by pH and a d-Peptide

1 reference

12 December 2020

10.1371/JOURNAL.PONE.0078399

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24244308%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24244308%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24244308%20AND%20SRC:MED&resulttype=core&format=json