Locus control region elements HS1 and HS4 enhance the therapeutic efficacy of globin gene transfer in beta-thalassemic mice. (Q41954465)

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8 January 2020

title

Locus control region elements HS1 and HS4 enhance the therapeutic efficacy of globin gene transfer in beta-thalassemic mice (English)

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1

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author name string

Michel Sadelain

series ordinal

2

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language of work or name

English

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publication date

5 October 2007

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8 January 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17921347%20AND%20SRC:MED&resulttype=core&format=json

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volume

110

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issue

13

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page(s)

4175-4178

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describes a project that uses

8 January 2020

ImageJ

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11 June 2022

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cites work

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Therapeutic options for patients with severe beta-thalassemia: the need for globin gene therapy

5 June 2018

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Differences of globin transgene expression in stably transfected cell lines and transgenic mice

5 June 2018

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High-level beta-globin expression and preferred intragenic integration after lentiviral transduction of human cord blood stem cells

5 June 2018

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Extended beta-globin locus control region elements promote consistent therapeutic expression of a gamma-globin lentiviral vector in murine beta-thalassemia

5 June 2018

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Side effects of retroviral gene transfer into hematopoietic stem cells

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Locus control regions

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Full activity from human beta-globin locus control region transgenes requires 5'HS1, distal beta-globin promoter, and 3' beta-globin sequences.

5 June 2018

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Scaffold/matrix-attached regions act upon transcription in a context-dependent manner

5 June 2018

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The regulatory element 3' to the A gamma-globin gene binds to the nuclear matrix and interacts with special A-T-rich binding protein 1 (SATB1), an SAR/MAR-associating region DNA binding protein.

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The degree of phenotypic correction of murine beta -thalassemia intermedia following lentiviral-mediated transfer of a human gamma-globin gene is influenced by chromosomal position effects and vector copy number

18 August 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/17921347

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Bone marrow transplantation in adult thalassemic patients

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PubMed

https://pubmed.ncbi.nlm.nih.gov/17921347

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1182/BLOOD-2007-08-108647

1 reference

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8 January 2020

1 reference

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8 January 2020

1 reference