The coenzyme specificity of Candida tenuis xylose reductase (AKR2B5) explored by site-directed mutagenesis and X-ray crystallography (Q41954443)

14 October 2017

The coenzyme specificity of Candida tenuis xylose reductase (AKR2B5) explored by site-directed mutagenesis and X-ray crystallography (English)

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14 October 2017

X-ray crystallography

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Candida tenuis

object named as

Candida tenuis

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5

Bernd Nidetzky

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author name string

Barbara Petschacher

1

1 reference

14 October 2017

Stefan Leitgeb

2

1 reference

14 October 2017

Kathryn L Kavanagh

3

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14 October 2017

David K Wilson

4

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14 October 2017

language of work or name

English

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publication date

1 January 2005

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14 October 2017

9

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inferred from page(s)

published in

Biochemical Journal

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14 October 2017

385

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14 October 2017

Pt 1

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14 October 2017

75-83

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describes a project that uses

14 October 2017

site-directed mutagenesis

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Structural alteration of cofactor specificity in Corynebacterium 2,5-diketo-D-gluconic acid reductase

inferred from title

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1 reference

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It is all about metabolic fluxes

5 June 2018

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Cloning and Characterization of the xyl1 Gene, Encoding an NADH-Preferring Xylose Reductase from Candida parapsilosis , and Its Functional Expression in Candida tropicalis

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5 June 2018

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The 2.3-A crystal structure of the shikimate 5-dehydrogenase orthologue YdiB from Escherichia coli suggests a novel catalytic environment for an NAD-dependent dehydrogenase

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5 June 2018

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The structure of apo and holo forms of xylose reductase, a dimeric aldo-keto reductase from Candida tenuis

5 June 2018

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Crystal structure of the malic enzyme from Ascaris suum complexed with nicotinamide adenine dinucleotide at 2.3 A resolution

5 June 2018

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5 June 2018

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Transient-state and steady-state kinetic studies of the mechanism of NADH-dependent aldehyde reduction catalyzed by xylose reductase from the yeast Candida tenuis

5 June 2018

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5 June 2018

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NADP-dependent bacterial alcohol dehydrogenases: crystal structure, cofactor-binding and cofactor specificity of the ADHs of Clostridium beijerinckii and Thermoanaerobacter brockii

5 June 2018

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Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

5 June 2018

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Crystal structure of 2,5-diketo-D-gluconic acid reductase A complexed with NADPH at 2.1-A resolution

5 June 2018

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NAD(P)H-dependent aldose reductase from the xylose-assimilating yeast Candida tenuis. Isolation, characterization and biochemical properties of the enzyme

5 June 2018

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5 June 2018

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5 June 2018

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Involvement of two basic residues (Lys-270 and Arg-276) of human liver 3 alpha-hydroxysteroid dehydrogenase in NADP(H) binding and activation by sulphobromophthalein: site-directed mutagenesis and kinetic analysis

5 June 2018

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5 June 2018

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5 June 2018

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5 June 2018

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5 June 2018

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5 June 2018

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5 June 2018

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5 June 2018

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5 June 2018

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5 June 2018

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Metabolic flux analysis of xylose metabolism in recombinant Saccharomyces cerevisiae using continuous culture

5 June 2018

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18 August 2018

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Fermentation performance and intracellular metabolite patterns in laboratory and industrial xylose-fermenting Saccharomyces cerevisiae

18 August 2018

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Optimizing an artificial metabolic pathway: engineering the cofactor specificity of Corynebacterium 2,5-diketo-D-gluconic acid reductase for use in vitamin C biosynthesis

18 August 2018

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Alteration of the specificity of the cofactor-binding pocket of Corynebacterium 2,5-diketo-D-gluconic acid reductase A.

18 August 2018

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Structural and functional properties of aldose xylose reductase from the D-xylose-metabolizing yeast Candida tenuis

18 August 2018

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The aldo-keto reductase (AKR) superfamily: an update

18 August 2018

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Noncovalent enzyme-substrate interactions in the catalytic mechanism of yeast aldose reductase.

18 August 2018

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Studies on pig aldose reductase. Identification of an essential arginine in the primary and tertiary structure of the enzyme.

18 August 2018

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The arginine 276 anchor for NADP(H) dictates fluorescence kinetic transients in 3 alpha-hydroxysteroid dehydrogenase, a representative aldo-keto reductase

18 August 2018

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12 December 2020

D-Xylose metabolism by Candida intermedia: isolation and characterisation of two forms of aldose reductase with different coenzyme specificities

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12 December 2020

Processing of X-ray diffraction data collected in oscillation mode

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12 December 2020

Studies on human aldose reductase. Probing the role of arginine 268 by site-directed mutagenesis

1 reference

12 December 2020

Mutational analysis of the role of the conserved lysine-270 in the Pichia stipitis xylose reductase

1 reference

12 December 2020

Aldehyde reductase: the role of C-terminal residues in defining substrate and cofactor specificities

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12 December 2020

Identifiers

DOI

10.1042/BJ20040363

1 reference

14 October 2017

1 reference

14 October 2017

PubMed publication ID

15320875

1 reference