Involvement of heparanase in the pathogenesis of acute kidney injury: nephroprotective effect of PG545. (Q41855773)

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17 March 2020

title

Involvement of heparanase in the pathogenesis of acute kidney injury: nephroprotective effect of PG545 (English)

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17 March 2020

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Valentina Masola

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17 March 2020

Maurizio Onisto

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17 March 2020

author name string

Zaid Abassi

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Shadi Hamoud

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Ahmad Hassan

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17 March 2020

Iyad Khamaysi

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Omri Nativ

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Samuel N Heyman

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Rabia Shekh Muhammad

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Neta Ilan

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Preeti Singh

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17 March 2020

Edward Hammond

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Antonio Lupo

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Gloria Bellin

14

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Israel Vlodavsky

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17 March 2020

Giovani Gambaro

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17 March 2020

language of work or name

English

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publication date

1 May 2017

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17 March 2020

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17 March 2020

volume

8

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17 March 2020

issue

21

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17 March 2020

page(s)

34191-34204

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Heparanase: roles in cell survival, extracellular matrix remodelling and the development of kidney disease

17 March 2020

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Heparanase: A Potential New Factor Involved in the Renal Epithelial Mesenchymal Transition (EMT) Induced by Ischemia/Reperfusion (I/R) Injury

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Heparanase mediates renal dysfunction during early sepsis in mice.

5 June 2018

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Mechanisms of heparanase inhibition by the heparan sulfate mimetic PG545 and three structural analogues

5 June 2018

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Versatile role of heparanase in inflammation

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Unexpected new roles for heparanase in Type 1 diabetes and immune gene regulation

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PG545, a heparan sulfate mimetic, reduces heparanase expression in vivo, blocks spontaneous metastases and enhances overall survival in the 4T1 breast carcinoma model

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Macrophage activation by heparanase is mediated by TLR-2 and TLR-4 and associates with plaque progression

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Elevated urine heparanase levels are associated with proteinuria and decreased renal allograft function

5 June 2018

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Heparanase is essential for the development of diabetic nephropathy in mice.

5 June 2018

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5 June 2018

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5 June 2018

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5 June 2018

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5 June 2018

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5 June 2018

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5 June 2018

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5 June 2018

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Subendothelial heparan sulfate proteoglycans become major L-selectin and monocyte chemoattractant protein-1 ligands upon renal ischemia/reperfusion

5 June 2018

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5 June 2018

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5 June 2018

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5 June 2018

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Early growth response gene 1 (EGR1) regulates heparanase gene transcription in tumor cells.

5 June 2018

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5 June 2018

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In vivo fragmentation of heparan sulfate by heparanase overexpression renders mice resistant to amyloid protein A amyloidosis

5 June 2018

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Acute renal failure: definitions, diagnosis, pathogenesis, and therapy

5 June 2018

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Transgenic expression of mammalian heparanase uncovers physiological functions of heparan sulfate in tissue morphogenesis, vascularization, and feeding behavior

5 June 2018

1 reference

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Increased expression of heparanase in puromycin aminonucleoside nephrosis

5 June 2018

1 reference

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Pathophysiology of ischemic acute renal failure

5 June 2018

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Heparanase: a key enzyme involved in cell invasion

5 June 2018

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Functions of cell surface heparan sulfate proteoglycans

5 June 2018

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Renal response to tissue injury: lessons from heme oxygenase-1 GeneAblation and expression

5 June 2018

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Inducible expression of Egr-1-dependent genes. A paradigm of transcriptional activation in vascular endothelium

5 June 2018

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The road from AKI to CKD: the role of endothelin

5 June 2018

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Experimental ischemia-reperfusion: biases and myths-the proximal vs. distal hypoxic tubular injury debate revisited.

18 August 2018

1 reference

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Induction of glomerular heparanase expression in rats with adriamycin nephropathy is regulated by reactive oxygen species and the renin-angiotensin system.

18 August 2018

1 reference

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Heparanase-1 gene expression and regulation by high glucose in renal epithelial cells: a potential role in the pathogenesis of proteinuria in diabetic patients

18 August 2018

1 reference

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Heparanase inhibition reduces proteinuria in a model of accelerated anti-glomerular basement membrane antibody disease.

18 August 2018

1 reference

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Heparanase is involved in the pathogenesis of proteinuria as a result of glomerulonephritis

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5470960

Heparanase Is Essential for the Development of Acute Experimental Glomerulonephritis

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5470960

A synthetic heparanase inhibitor reduces proteinuria in passive Heymann nephritis

2 December 2018

1 reference

12 December 2020

Urinary heparanase activity in patients with Type 1 and Type 2 diabetes

1 reference

12 December 2020

1 reference

12 December 2020

Identification of Neutrophil Gelatinase-Associated Lipocalin as a Novel Early Urinary Biomarker for Ischemic Renal Injury

1 reference

12 December 2020

Gene expression for endothelins and their receptors in glomeruli of diabetic rats

1 reference

12 December 2020

Increased expression of heparanase in overt diabetic nephropathy

1 reference

12 December 2020

10.18632/ONCOTARGET.16573

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28388547%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28388547%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

PubMed publication ID

28388547

1 reference