New models of pulmonary hypertension based on VEGF receptor blockade-induced endothelial cell apoptosis (Q41853468)

13 October 2017

1 reference

title

New models of pulmonary hypertension based on VEGF receptor blockade-induced endothelial cell apoptosis (English)

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13 October 2017

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Mark R Nicolls

1

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13 October 2017

Shiro Mizuno

2

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13 October 2017

Laima Taraseviciene-Stewart

3

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13 October 2017

Laszlo Farkas

4

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13 October 2017

Jennnifer I Drake

5

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13 October 2017

Aysar Al Husseini

6

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13 October 2017

Jose G Gomez-Arroyo

7

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13 October 2017

Norbert F Voelkel

8

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13 October 2017

Herman J Bogaard

9

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13 October 2017

1 October 2012

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13 October 2017

Pulmonary circulation

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13 October 2017

2

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13 October 2017

434-442

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13 October 2017

4

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Severe pulmonary arterial hypertension induced by SU5416 and ovalbumin immunization

13 October 2017

1 reference

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Regulatory T cells and pulmonary hypertension

5 June 2018

1 reference

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Pathobiology of pulmonary arterial hypertension and right ventricular failure

5 June 2018

1 reference

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Predicting the effects of anti-angiogenic agents targeting specific VEGF isoforms.

5 June 2018

1 reference

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5 June 2018

1 reference

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Notch-dependent VEGFR3 upregulation allows angiogenesis without VEGF-VEGFR2 signalling

5 June 2018

1 reference

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Role of shear-stress-induced VEGF expression in endothelial cell survival

5 June 2018

1 reference

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Antiangiogenic agents increase breast cancer stem cells via the generation of tumor hypoxia

5 June 2018

1 reference

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A brief overview of mouse models of pulmonary arterial hypertension: problems and prospects

5 June 2018

1 reference

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Copper dependence of angioproliferation in pulmonary arterial hypertension in rats and humans

5 June 2018

1 reference

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VEGFR2 translocates to the nucleus to regulate its own transcription

5 June 2018

1 reference

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The monocrotaline model of pulmonary hypertension in perspective

5 June 2018

1 reference

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Altered MicroRNA processing in heritable pulmonary arterial hypertension: an important role for Smad-8

5 June 2018

1 reference

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Regulatory T cells limit vascular endothelial injury and prevent pulmonary hypertension.

5 June 2018

1 reference

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Design and validation of an endothelial progenitor cell capture chip and its application in patients with pulmonary arterial hypertension

5 June 2018

1 reference

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Molecular signature of a right heart failure program in chronic severe pulmonary hypertension.

5 June 2018

1 reference

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Inhibitory effects of SU5416, a selective vascular endothelial growth factor receptor tyrosine kinase inhibitor, on experimental corneal neovascularization

5 June 2018

1 reference

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Clinical trials using vasodilators in pulmonary arterial hypertension: where do we go from here?

5 June 2018

1 reference

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Cell-based therapies in pulmonary hypertension: who, what, and when?

5 June 2018

1 reference

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Antiangiogenic therapy: impact on invasion, disease progression, and metastasis.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555413

The effects of antiangiogenic compound SU5416 in a rat model of pulmonary arterial hypertension

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555413

Strategic plan for lung vascular research: An NHLBI-ORDR Workshop Report

5 June 2018

1 reference

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Cardiovascular involvement in patients with different causes of hyperthyroidism

5 June 2018

1 reference

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Targeting the tumour vasculature: insights from physiological angiogenesis

5 June 2018

1 reference

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Endothelial progenitors in pulmonary hypertension: new pathophysiology and therapeutic implications.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555413

Vascular endothelial growth factor receptor-2 inhibition promotes cell death and limits endothelial cell proliferation in a neonatal rodent model of stroke

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555413

Chronic pulmonary artery pressure elevation is insufficient to explain right heart failure.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555413

Animal models of pulmonary arterial hypertension: the hope for etiological discovery and pharmacological cure.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555413

Inflammation, growth factors, and pulmonary vascular remodeling

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555413

VEGF ameliorates pulmonary hypertension through inhibition of endothelial apoptosis in experimental lung fibrosis in rats

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555413

Emerging concepts and translational priorities in pulmonary arterial hypertension

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555413

Molecular pathogenesis of pulmonary arterial hypertension

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555413

The cancer paradigm of severe pulmonary arterial hypertension

5 June 2018

1 reference

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Pulmonary arterial remodeling induced by a Th2 immune response

5 June 2018

1 reference

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A meta-analysis of trials of pulmonary hypertension: a clinical condition looking for drugs and research methodology

5 June 2018

1 reference

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VEGF receptor inhibition blocks liver cyst growth in pkd2(WS25/-) mice

5 June 2018

1 reference

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Absence of T cells confers increased pulmonary arterial hypertension and vascular remodeling

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555413

Distinct roles of VEGFR-1 and VEGFR-2 in the aberrant hematopoiesis associated with elevated levels of VEGF.

5 June 2018

1 reference

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Vascular endothelial growth factor blockade reduces intratumoral regulatory T cells and enhances the efficacy of a GM-CSF-secreting cancer immunotherapy

5 June 2018

1 reference

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Autoimmunity and pulmonary hypertension: a perspective

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555413

Initial apoptosis is followed by increased proliferation of apoptosis-resistant endothelial cells

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555413

Internal and external autocrine VEGF/KDR loops regulate survival of subsets of acute leukemia through distinct signaling pathways

5 June 2018

1 reference

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Peroxisome Proliferator-Activated Receptor Gamma (PPARγ) Expression Is Decreased in Pulmonary Hypertension and Affects Endothelial Cell Growth

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555413

Janus face of vascular endothelial growth factor: the obligatory survival factor for lung vascular endothelium controls precapillary artery remodeling in severe pulmonary hypertension

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555413

Inhibition of VEGF receptors causes lung cell apoptosis and emphysema

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555413

Role of alphavbeta3 integrin in the activation of vascular endothelial growth factor receptor-2.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555413

SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, and growth of multiple tumor types

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555413

Integrin alphavbeta3 requirement for sustained mitogen-activated protein kinase activity during angiogenesis

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555413

Pulmonary hemodynamics modify the rat pulmonary artery response to injury. A neointimal model of pulmonary hypertension

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555413

Thyroid hormone is highly permissive in angioproliferative pulmonary hypertension in rats.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555413

Pulmonary arterial hypertension in patients treated by dasatinib

18 August 2018

1 reference

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Anti-vascular endothelial growth factor treatment in combination with chemotherapy delays hematopoietic recovery due to decreased proliferation of bone marrow hematopoietic progenitor cells

18 August 2018

1 reference

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A novel thiol compound, N-acetylcysteine amide, attenuates allergic airway disease by regulating activation of NF-kappaB and hypoxia-inducible factor-1alpha

18 August 2018

1 reference

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Simvastatin causes endothelial cell apoptosis and attenuates severe pulmonary hypertension.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555413

Matrix-bound sixth Ig-like domain of cell adhesion molecule L1 acts as an angiogenic factor by ligating alphavbeta3-integrin and activating VEGF-R2.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555413

Proangiogenic action of thyroid hormone is fibroblast growth factor-dependent and is initiated at the cell surface

18 August 2018

1 reference

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Athymic nude rats develop severe pulmonary hypertension following monocrotaline administration.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555413

Airway inflammation is augmented by obesity and fatty acids in asthma.

18 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.4103%2F2045-8932.105031

Inhibition of the VEGF receptor 2 combined with chronic hypoxia causes cell death-dependent pulmonary endothelial cell proliferation and severe pulmonary hypertension

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.4103%2F2045-8932.105031

Rho kinase-mediated vasoconstriction is important in severe occlusive pulmonary arterial hypertension in rats

21 January 2018

1 reference

12 December 2020

Inhibition of angiogenesis decreases alveolarization in the developing rat lung

1 reference

12 December 2020

Prolonged hypoxic culture and trypsinization increase the pro-angiogenic potential of human adipose tissue-derived stem cells

1 reference

12 December 2020

VEGF-C promotes immune tolerance in B16 melanomas and cross-presentation of tumor antigen by lymph node lymphatics

1 reference

12 December 2020

Formation of plexiform lesions in experimental severe pulmonary arterial hypertension

1 reference

12 December 2020

Identifiers

DOI

10.4103/2045-8932.105031

1 reference

13 October 2017

1 reference

13 October 2017

1 reference