Nanoparticle-formulated siRNA targeting integrins inhibits hepatocellular carcinoma progression in mice. (Q41847265)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24844798%20AND%20SRC:MED&resulttype=core&format=json

18 March 2020

title

Nanoparticle-formulated siRNA targeting integrins inhibits hepatocellular carcinoma progression in mice (English)

1 reference

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18 March 2020

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3

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18 March 2020

Vera M Ruda

5

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18 March 2020

Victor E. Koteliansky

8

object named as

Victor Koteliansky

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18 March 2020

author name string

Roman L Bogorad

1

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18 March 2020

Hao Yin

2

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18 March 2020

Hidenori Nonaka

4

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18 March 2020

Marino Zerial

6

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18 March 2020

Daniel G Anderson

7

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18 March 2020

language of work or name

English

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publication date

21 May 2014

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18 March 2020

published in

Nature Communications

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18 March 2020

volume

5

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18 March 2020

page(s)

3869

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describes a project that uses

18 March 2020

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4107318/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

exact match

https://scigraph.springernature.com/pub.10.1038/ncomms4869

0 references

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Hepatocellular carcinoma biology

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Treatment of erythropoietin deficiency in mice with systemically administered siRNA.

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αV integrins in angiogenesis and cancer

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Fate tracing of mature hepatocytes in mouse liver homeostasis and regeneration

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Molecular targeting of CSN5 in human hepatocellular carcinoma: a mechanism of therapeutic response

5 June 2018

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Coactivation of AKT and β-catenin in mice rapidly induces formation of lipogenic liver tumors

5 June 2018

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Ligand-independent activation of c-Met by fibronectin and α(5)β(1)-integrin regulates ovarian cancer invasion and metastasis

5 June 2018

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Activation of integrins by urea in perfused rat liver

5 June 2018

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Lipid-like materials for low-dose, in vivo gene silencing

5 June 2018

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Integrins in cancer: biological implications and therapeutic opportunities

5 June 2018

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Off-target and a portion of target-specific siRNA mediated mRNA degradation is Ago2 'Slicer' independent and can be mediated by Ago1.

5 June 2018

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An activating beta1 integrin mutation increases the conversion of benign to malignant skin tumors.

5 June 2018

1 reference

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An oncogenomics-based in vivo RNAi screen identifies tumor suppressors in liver cancer

5 June 2018

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Importance of translation and nonnucleolytic ago proteins for on-target RNA interference

5 June 2018

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Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates

5 June 2018

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Sorafenib in advanced hepatocellular carcinoma

5 June 2018

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Distinct pathways of genomic progression to benign and malignant tumors of the liver.

5 June 2018

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A guided tour into subcellular colocalization analysis in light microscopy

5 June 2018

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Beta1 integrin inhibitory antibody induces apoptosis of breast cancer cells, inhibits growth, and distinguishes malignant from normal phenotype in three dimensional cultures and in vivo

5 June 2018

1 reference

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ECM overrides DNA damage-induced cell cycle arrest and apoptosis in small-cell lung cancer cells through beta1 integrin-dependent activation of PI3-kinase

5 June 2018

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beta 1 integrin function in vivo: adhesion, migration and more

5 June 2018

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Hereditary persistence of alpha-fetoprotein and H19 expression in liver of BALB/cJ mice is due to a retrovirus insertion in the Zhx2 gene.

5 June 2018

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Beta1-integrin orients epithelial polarity via Rac1 and laminin

5 June 2018

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Alterations of beta-catenin pathway in non-melanoma skin tumors: loss of alpha-ABC nuclear reactivity correlates with the presence of beta-catenin gene mutation

5 June 2018

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Beta1 integrins regulate chondrocyte rotation, G1 progression, and cytokinesis

5 June 2018

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Integrins: bidirectional, allosteric signaling machines

5 June 2018

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Matrix assembly, regulation, and survival functions of laminin and its receptors in embryonic stem cell differentiation

5 June 2018

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Sensing the environment: a historical perspective on integrin signal transduction

5 June 2018

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A signaling adapter function for alpha6beta4 integrin in the control of HGF-dependent invasive growth

5 June 2018

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Cross talk between beta(1) and alpha(V) integrins: beta(1) affects beta(3) mRNA stability

5 June 2018

1 reference

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Activation of the Met receptor by cell attachment induces and sustains hepatocellular carcinomas in transgenic mice

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107318

Skin and hair follicle integrity is crucially dependent on beta 1 integrin expression on keratinocytes

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107318

Altered synthesis of laminin 1 and absence of basement membrane component deposition in (beta)1 integrin-deficient embryoid bodies

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107318

Perturbation of beta1-integrin function alters the development of murine mammary gland

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107318

Tyrosines1234-1235 are critical for activation of the tyrosine kinase encoded by the MET proto-oncogene (HGF receptor).

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107318

Anchorage dependence, integrins, and apoptosis

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107318

Co-operative regulation of endocytosis by three Rab5 isoforms

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107318

Consequences of lack of beta 1 integrin gene expression in mice

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107318

Deletion of beta 1 integrins in mice results in inner cell mass failure and peri-implantation lethality

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107318

Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60src

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107318

Parenchymal cells from adult rat liver in nonproliferating monolayer culture. I. Functional studies

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107318

Biosynthesis and acquisition of biological activity of the fibronectin receptor

5 June 2018

1 reference

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Role of cell shape in growth control

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107318

Knockdown and knockout of β1-integrin in hepatocytes impairs liver regeneration through inhibition of growth factor signalling.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107318

Extracellular matrix modulates sensitivity of hepatocytes to fibroblastoid dedifferentiation and transforming growth factor beta-induced apoptosis.

18 August 2018

1 reference

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Hepatocellular carcinoma in Txnip-deficient mice.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107318

Involvement of integrins and Src in tauroursodeoxycholate-induced and swelling-induced choleresis

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107318

Cell proliferation and renewal of normal hepatocytes and bile duct cells in adult mouse liver

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107318

Integrin signaling inhibits paclitaxel-induced apoptosis in breast cancer cells

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107318

Expression and cellular distribution of alpha(v)integrins in beta(1)integrin-deficient embryonic stem cell-derived cardiac cells.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107318

Manifestations of hypercholesterolaemia, hypoglycaemia, erythrocytosis and hypercalcaemia in patients with hepatocellular carcinoma: report of two cases

18 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24844798

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Biosynthesis of the protein encoded by the c-met proto-oncogene

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24844798

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NCOMMS4869

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24844798%20AND%20SRC:MED&resulttype=core&format=json

18 March 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24844798%20AND%20SRC:MED&resulttype=core&format=json

18 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24844798%20AND%20SRC:MED&resulttype=core&format=json