Targeted delivery of antisense oligonucleotides to hepatocytes using triantennary N-acetyl galactosamine improves potency 10-fold in mice. (Q41846059)

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21 March 2020

title

Targeted delivery of antisense oligonucleotides to hepatocytes using triantennary N-acetyl galactosamine improves potency 10-fold in mice (English)

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14

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author name string

Thazha P Prakash

1

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Mark J Graham

2

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21 March 2020

Jinghua Yu

3

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Rick Carty

4

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Audrey Low

5

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Alfred Chappell

6

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Karsten Schmidt

7

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Chenguang Zhao

8

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Mariam Aghajan

9

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Heather F Murray

10

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Stan Riney

11

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Sheri L Booten

12

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Susan F Murray

13

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Jeff Crosby

15

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Walt F Lima

16

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Shuling Guo

17

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Brett P Monia

18

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Eric E Swayze

19

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Punit P Seth

20

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publication date

3 July 2014

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21 March 2020

published in

Nucleic Acids Research

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volume

42

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21 March 2020

page(s)

8796-8807

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issue

13

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Creative Commons Attribution 3.0 Unported

21 March 2020

copyright license

start time

4 October 2016

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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Synthesis of cluster galactosides with high affinity for the hepatic asialoglycoprotein receptor.

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Design and synthesis of novel N-acetylgalactosamine-terminated glycolipids for targeting of lipoproteins to the hepatic asialoglycoprotein receptor

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Gene transfer into hepatocytes using asialoglycoprotein receptor mediated endocytosis of DNA complexed with an artificial tetra-antennary galactose ligand.

21 January 2018

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Targeted delivery of oligodeoxynucleotides to parenchymal liver cells in vivo.

21 January 2018

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TricycloDNA-modified oligo-2'-deoxyribonucleotides reduce scavenger receptor B1 mRNA in hepatic and extra-hepatic tissues--a comparative study of oligonucleotide length, design and chemistry.

21 January 2018

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Targeted suppression of an amyloidogenic transthyretin with antisense oligonucleotides

21 January 2018

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Synthesis and biophysical evaluation of 2',4'-constrained 2'O-methoxyethyl and 2',4'-constrained 2'O-ethyl nucleic acid analogues.

21 January 2018

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Inhibition of the intrinsic coagulation pathway factor XI by antisense oligonucleotides: a novel antithrombotic strategy with lowered bleeding risk.

21 January 2018

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Antithrombotic effect of antisense factor XI oligonucleotide treatment in primates

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Antisense oligonucleotide treatment ameliorates alpha-1 antitrypsin-related liver disease in mice.

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Antisense oligonucleotide inhibition of apolipoprotein C-III reduces plasma triglycerides in rodents, nonhuman primates, and humans

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Cross-species comparison of in vivo PK/PD relationships for second-generation antisense oligonucleotides targeting apolipoprotein B-100.

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In vivo fate of phosphorothioate antisense oligodeoxynucleotides: predominant uptake by scavenger receptors on endothelial liver cells

21 January 2018

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Inducing host protection in pneumococcal sepsis by preactivation of the Ashwell-Morell receptor

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Cellular uptake and intracellular trafficking of oligonucleotides: implications for oligonucleotide pharmacology

21 January 2018

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Short antisense oligonucleotides with novel 2'-4' conformationaly restricted nucleoside analogues show improved potency without increased toxicity in animals

21 January 2018

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Short locked nucleic acid antisense oligonucleotides potently reduce apolipoprotein B mRNA and serum cholesterol in mice and non-human primates

21 January 2018

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Synthesis, Improved Antisense Activity and Structural Rationale for the Divergent RNA Affinities of 3′-Fluoro Hexitol Nucleic Acid (FHNA and Ara-FHNA) Modified Oligonucleotides

21 January 2018

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Identifiers

DOI

10.1093/NAR/GKU531

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21 March 2020

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21 March 2020

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