Mechanism of LDL binding and release probed by structure-based mutagenesis of the LDL receptor (Q41833733)

12 October 2017

Mechanism of LDL binding and release probed by structure-based mutagenesis of the LDL receptor (English)

1 reference

12 October 2017

Sha Huang

1

1 reference

12 October 2017

Lisa Henry

2

1 reference

12 October 2017

Yiu Kee Ho

3

1 reference

12 October 2017

Henry J Pownall

4

1 reference

12 October 2017

Gabby Rudenko

5

1 reference

12 October 2017

11 August 2009

1 reference

Journal of Lipid Research

12 October 2017

1 reference

12 October 2017

51

1 reference

12 October 2017

2

1 reference

12 October 2017

297-308

1 reference

Molecular studies of pH-dependent ligand interactions with the low-density lipoprotein receptor

12 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2803231

Structural requirements for PCSK9-mediated degradation of the low-density lipoprotein receptor

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2803231

The epidermal growth factor homology domain of the LDL receptor drives lipoprotein release through an allosteric mechanism involving H190, H562, and H586.

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2803231

Mechanism of low density lipoprotein (LDL) release in the endosome: implications of the stability and Ca2+ affinity of the fifth binding module of the LDL receptor.

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2803231

Binding site structure of one LRP-RAP complex: implications for a common ligand-receptor binding motif

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2803231

Folding and binding integrity of variants of a prototype ligand-binding module from the LDL receptor possessing multiple alanine substitutions

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2803231

Low-density lipoprotein receptor--its structure, function, and mutations

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2803231

The low-density lipoprotein receptor: ligands, debates and lore

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2803231

Structure of the LDL receptor extracellular domain at endosomal pH

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2803231

The UMD-LDLR database: additions to the software and 490 new entries to the database.

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2803231

pH-dependent regulation of lysosomal calcium in macrophages

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2803231

Calcium coordination and pH dependence of the calcium affinity of ligand-binding repeat CR7 from the LRP. Comparison with related domains from the LRP and the LDL receptor

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2803231

Implications for familial hypercholesterolemia from the structure of the LDL receptor YWTD-EGF domain pair

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2803231

Calcium uptake via endocytosis with rapid release from acidifying endosomes.

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2803231

Identification of the low density lipoprotein receptor-binding site in apolipoprotein B100 and the modulation of its binding activity by the carboxyl terminus in familial defective apo-B100.

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2803231

Molecular basis of familial hypercholesterolaemia from structure of LDL receptor module

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2803231

The human LDL receptor: a cysteine-rich protein with multiple Alu sequences in its mRNA

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2803231

Familial hypercholesterolemia: defective binding of lipoproteins to cultured fibroblasts associated with impaired regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2803231

Acid-dependent ligand dissociation and recycling of LDL receptor mediated by growth factor homology region

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2803231

Mutational analysis of the ligand binding domain of the low density lipoprotein receptor

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2803231

Apolipoprotein E: cholesterol transport protein with expanding role in cell biology

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2803231

Human apolipoprotein B: structure of carboxyl-terminal domains, sites of gene expression, and chromosomal localization

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2803231

Analysis of a recycling-impaired mutant of low density lipoprotein receptor in familial hypercholesterolemia

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2803231

Stoichiometric binding of low density lipoprotein (LDL) and monoclonal antibodies to LDL receptors in a solid phase assay

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2803231

Different combinations of cysteine-rich repeats mediate binding of low density lipoprotein receptor to two different proteins

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2803231

Deletion of two growth-factor repeats from the low-density-lipoprotein receptor accelerates its degradation

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2803231

Update and analysis of the University College London low density lipoprotein receptor familial hypercholesterolemia database

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2803231

Biomedicine. Lowering LDL--not only how low, but how long?

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2803231

Intracellular fate of LDL receptor family members depends on the cooperation between their ligand-binding and EGF domains

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2803231

Cooperation between fixed and low pH-inducible interfaces controls lipoprotein release by the LDL receptor

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2803231

Molecular medicine. The cholesterol quartet

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2803231

Structure of an LDLR-RAP complex reveals a general mode for ligand recognition by lipoprotein receptors

18 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19674976

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Binding characteristics of a panel of monoclonal antibodies against the ligand binding domain of the human LDLr

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19674976

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

19 Receptor-mediated endocytosis of low-density lipoprotein in cultured cells

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19674976

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1194/JLR.M000422

1 reference

12 October 2017

1 reference

12 October 2017

1 reference