A chemical genetic approach reveals that p38alpha MAPK activation by diphosphorylation aggravates myocardial infarction and is prevented by the direct binding of SB203580. (Q41813960)

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scientific article published on 7 December 2009

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English	A chemical genetic approach reveals that p38alpha MAPK activation by diphosphorylation aggravates myocardial infarction and is prevented by the direct binding of SB203580.	scientific article published on 7 December 2009

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19996096%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

A chemical genetic approach reveals that p38alpha MAPK activation by diphosphorylation aggravates myocardial infarction and is prevented by the direct binding of SB203580 (English)

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14 February 2020

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14 February 2020

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14 February 2020

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14 February 2020

Michael S. Marber

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14 February 2020

Stephen J. O'Keefe

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Stephen J O'Keefe

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14 February 2020

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Sarawut Kumphune

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14 February 2020

Rekha Bassi

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14 February 2020

Sebastien Jacquet

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14 February 2020

Sharwari Verma

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14 February 2020

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7 December 2009

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14 February 2020

Journal of Biological Chemistry

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14 February 2020

285

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14 February 2020

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14 February 2020

2968-2975

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14 February 2020

T cell receptor-mediated activation of p38{alpha} by mono-phosphorylation of the activation loop results in altered substrate specificity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2823430

6 June 2018

Enzymatic activity and substrate specificity of mitogen-activated protein kinase p38alpha in different phosphorylation states

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2823430

6 June 2018

The role of RIP2 in p38 MAPK activation in the stressed heart

1 reference

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6 June 2018

Potential of p38-MAPK inhibitors in the treatment of ischaemic heart disease

1 reference

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6 June 2018

A chaperone-dependent GSK3beta transitional intermediate mediates activation-loop autophosphorylation

1 reference

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6 June 2018

cGMP-dependent protein kinase type I inhibits TAB1-p38 mitogen-activated protein kinase apoptosis signaling in cardiac myocytes

1 reference

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6 June 2018

Activation-loop autophosphorylation is mediated by a novel transitional intermediate form of DYRKs

1 reference

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6 June 2018

BIRB796 inhibits all p38 MAPK isoforms in vitro and in vivo.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2823430

6 June 2018

Targeted inhibition of p38 mitogen-activated protein kinase antagonizes cardiac injury and cell death following ischemia-reperfusion in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2823430

6 June 2018

An efficient proteomics method to identify the cellular targets of protein kinase inhibitors.

1 reference

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6 June 2018

Further evidence that the tyrosine phosphorylation of glycogen synthase kinase-3 (GSK3) in mammalian cells is an autophosphorylation event

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2823430

6 June 2018

Diverse mechanisms of myocardial p38 mitogen-activated protein kinase activation: evidence for MKK-independent activation by a TAB1-associated mechanism contributing to injury during myocardial ischemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2823430

6 June 2018

MAPKK-independent activation of p38alpha mediated by TAB1-dependent autophosphorylation of p38alpha

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2823430

6 June 2018

The role of differential activation of p38-mitogen-activated protein kinase in preconditioned ventricular myocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2823430

6 June 2018

Use of a drug-resistant mutant of stress-activated protein kinase 2a/p38 to validate the in vivo specificity of SB 203580.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2823430

6 June 2018

Acquisition of sensitivity of stress-activated protein kinases to the p38 inhibitor, SB 203580, by alteration of one or more amino acids within the ATP binding pocket

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2823430

6 June 2018

Integrin-mediated transfection with peptides containing arginine-glycine-aspartic acid domains

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2823430

6 June 2018

Crystal structure of p38 mitogen-activated protein kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2823430

6 June 2018

MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2823430

6 June 2018

PKC maturation is promoted by nucleotide pocket occupation independently of intrinsic kinase activity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2823430

18 August 2018

Glycogen synthase kinase-3 inactivation is not required for ischemic preconditioning or postconditioning in the mouse

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2823430

18 August 2018

Disruption of a single copy of the p38alpha MAP kinase gene leads to cardioprotection against ischemia-reperfusion.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2823430

18 August 2018

Activation of p38 Mitogen-Activated Protein Kinase Contributes to the Early Cardiodepressant Action of Tumor Necrosis Factor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.079228

21 January 2018

Structures of p38alpha active mutants reveal conformational changes in L16 loop that induce autophosphorylation and activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19996096

12 December 2020

based on heuristic

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Chemical genetics define the roles of p38alpha and p38beta in acute and chronic inflammation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19996096

12 December 2020

based on heuristic

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10.1074/JBC.M109.079228

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19996096%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

release_wokbai2lf5hvzaggaaxdfnqfou

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24 November 2022

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19996096%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

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14 February 2020

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