Pro- and anti-inflammatory actions of thrombin: a distinct role for proteinase-activated receptor-1 (PAR1). (Q41811842)

12 October 2017

Pro- and anti-inflammatory actions of thrombin: a distinct role for proteinase-activated receptor-1 (PAR1). (English)

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12 October 2017

N Vergnolle

1

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author name string

M D Hollenberg

series ordinal

2

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12 October 2017

J L Wallace

series ordinal

3

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12 October 2017

language of work or name

English

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publication date

1 March 1999

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British Journal of Pharmacology

12 October 2017

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12 October 2017

126

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12 October 2017

5

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12 October 2017

1262-1268

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Increased vascular permeability by a specific agonist of protease-activated receptor-2 in rat hindpaw

12 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1565884

A dual thrombin receptor system for platelet activation

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1565884

Proteinase-activated receptor 2 (PAR2)-activating peptides: identification of a receptor distinct from PAR2 that regulates intestinal transport

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1565884

Cloning and characterization of human protease-activated receptor 4

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1565884

Protease-activated receptor 3 is a second thrombin receptor in humans

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1565884

Synergistic actions of a thrombin-derived synthetic peptide and a thrombin receptor-activating peptide in stimulating fibroblast mitogenesis

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1565884

Protease-mediated signalling: new paradigms for cell regulation and drug development

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1565884

Thrombin functions as an inflammatory mediator through activation of its receptor

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1565884

Thrombin induces endothelial cell growth via both a proteolytic and a non-proteolytic pathway

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1565884

Molecular cloning of a potential proteinase activated receptor

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1565884

Contractile actions of thrombin receptor‐derived polypeptides in human umbilical and placental vasculature: evidence for distinct receptor systems

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1565884

Synthetic peptides bind to high-affinity thrombin receptors and modulate thrombin mitogenesis

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1565884

Structure of the hirugen and hirulog 1 complexes of alpha-thrombin

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1565884

Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1565884

Thrombin-Mediated Increase in Vascular Endothelial Permeability

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1565884

Thrombin receptor expression in normal and atherosclerotic human arteries

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1565884

Action of thrombin receptor polypeptide in gastric smooth muscle: identification of a core pentapeptide retaining full thrombin-mimetic intrinsic activity

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1565884

Structure-function relationships in the activation of platelet thrombin receptors by receptor-derived peptides

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1565884

Selective release of archidonic acid from the phospholipids of human platelets in response to thrombin

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1565884

Stimulation of Endothelial Cell Prostacyclin Production by Thrombin, Trypsin, and the Ionophore A 23187

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1565884

Ligand cross-reactivity within the protease-activated receptor family.

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1565884

Studies on the mediators of the acute inflammatory response induced in rats in different sites by carrageenan and turpentine.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1565884

cDNA cloning and expression of a hamster alpha-thrombin receptor coupled to Ca2+ mobilization.

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1565884

Monocyte chemotaxis: stimulation by specific exosite region in thrombin

18 August 2018

1 reference

12 December 2020

Thrombin-induced degranulation of cultured bone marrow-derived mast cells

1 reference

12 December 2020

Thrombin-induced chemotaxis and aggregation of neutrophils

1 reference

12 December 2020

Characterization of the enhanced adhesion of neutrophil leukocytes to thrombin-stimulated endothelial cells

1 reference

12 December 2020

Design and characterization of hirulogs: a novel class of bivalent peptide inhibitors of thrombin

1 reference

12 December 2020

The role of thrombin and thrombin receptor activating peptide (TRAP-508) in initiation of tissue repair

1 reference

12 December 2020

Thrombin-induced phosphorylation and activation of Ca(2+)-sensitive cytosolic phospholipase A2 in human platelets

1 reference

12 December 2020

Tight binding inhibitors of 85-kDa phospholipase A2 but not 14-kDa phospholipase A2 inhibit release of free arachidonate in thrombin-stimulated human platelets

1 reference

12 December 2020

cGMP and nitric oxide modulate thrombin-induced endothelial permeability. Regulation via different pathways in human aortic and umbilical vein endothelial cells

1 reference

12 December 2020

Endothelin 1 and thrombin synergistically stimulate IL-6 mRNA expression and protein production in human umbilical vein endothelial cells

1 reference

12 December 2020

Thrombin stimulates production of interleukin-8 in human umbilical vein endothelial cells

1 reference

12 December 2020

Thrombin potently stimulates cytokine production in human vascular smooth muscle cells but not in mononuclear phagocytes.

1 reference

12 December 2020

Proteinase-activated receptors: structural requirements for activity, receptor cross-reactivity, and receptor selectivity of receptor-activating peptides

1 reference

12 December 2020

Evaluation of proteinase-activated receptor-1 (PAR1) agonists and antagonists using a cultured cell receptor desensitization assay: activation of PAR2 by PAR1-targeted ligands

1 reference

12 December 2020

Localization of a chemotactic domain in human thrombin

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12 December 2020

Identifiers

DOI

10.1038/SJ.BJP.0702408

1 reference

12 October 2017

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12 October 2017

PubMed publication ID

10205017

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