Isolation and characterization of signermycin B, an antibiotic that targets the dimerization domain of histidine kinase WalK (Q41811635)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22526318%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

title

Isolation and characterization of signermycin B, an antibiotic that targets the dimerization domain of histidine kinase WalK (English)

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29 January 2020

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3

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29 January 2020

Ryuichi Sawa

7

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29 January 2020

Tomoyuki Kimura

9

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29 January 2020

author name string

Takafumi Watanabe

1

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29 January 2020

Masayuki Igarashi

2

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29 January 2020

Eiji Ishii

4

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29 January 2020

Hirokazu Kino

5

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29 January 2020

Masaki Hatano

6

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29 January 2020

Maya Umekita

8

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29 January 2020

Sho Okamoto

10

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29 January 2020

Yoko Eguchi

11

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29 January 2020

Yuzuru Akamatsu

12

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29 January 2020

Ryutaro Utsumi

13

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29 January 2020

language of work or name

English

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publication date

23 April 2012

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Antimicrobial Agents and Chemotherapy

29 January 2020

number of pages

7

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based on heuristic

inferred from page(s)

published in

1 reference

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29 January 2020

volume

56

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29 January 2020

page(s)

3657-3663

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29 January 2020

issue

7

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Development of an antivirulence drug against Streptococcus mutans: repression of biofilm formation, acid tolerance, and competence by a histidine kinase inhibitor, walkmycin C

29 January 2020

cites work

1 reference

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Two-component signal transduction as potential drug targets in pathogenic bacteria

6 June 2018

1 reference

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Jamming bacterial communication: new approaches for the treatment of infectious diseases

6 June 2018

1 reference

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Biological insights from structures of two-component proteins

6 June 2018

1 reference

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A matter of life and death: cell wall homeostasis and the WalKR (YycGF) essential signal transduction pathway

6 June 2018

1 reference

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Response regulator YycF essential for bacterial growth: X-ray crystal structure of the DNA-binding domain and its PhoB-like DNA recognition motif

6 June 2018

1 reference

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Targeting QseC signaling and virulence for antibiotic development

6 June 2018

1 reference

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The biology and future prospects of antivirulence therapies

6 June 2018

1 reference

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New insights into the WalK/WalR (YycG/YycF) essential signal transduction pathway reveal a major role in controlling cell wall metabolism and biofilm formation in Staphylococcus aureus

6 June 2018

1 reference

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Characterization of IsaA and SceD, two putative lytic transglycosylases of Staphylococcus aureus

6 June 2018

1 reference

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An antibiotic-inducible cell wall-associated protein that protects Bacillus subtilis from autolysis

6 June 2018

1 reference

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Targeting protein homodimerization: a novel drug discovery system

6 June 2018

1 reference

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Developing inhibitors to selectively target two-component and phosphorelay signal transduction systems of pathogenic microorganisms

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3393415

Identification of genes controlled by the essential YycG/YycF two-component system of Staphylococcus aureus

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3393415

Competence repression under oxygen limitation through the two-component MicAB signal-transducing system in Streptococcus pneumoniae and involvement of the PAS domain of MicB.

6 June 2018

1 reference

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Inhibitors of bacterial two-component signalling systems

6 June 2018

1 reference

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The mechanism of action of inhibitors of bacterial two-component signal transduction systems

6 June 2018

1 reference

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The essential two-component regulatory system encoded by yycF and yycG modulates expression of the ftsAZ operon in Bacillus subtilis

6 June 2018

1 reference

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Solution structure of the homodimeric core domain of Escherichia coli histidine kinase EnvZ

6 June 2018

1 reference

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Multiple mechanisms of action for inhibitors of histidine protein kinases from bacterial two-component systems

6 June 2018

1 reference

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A two-component signal transduction system essential for growth of Bacillus subtilis: implications for anti-infective therapy.

6 June 2018

1 reference

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X-ray crystal structure of the DNA-binding domain of response regulator WalR essential to the cell viability of staphylococcus aureus and interaction with target DNA.

6 June 2018

1 reference

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Novel antibacterial compounds specifically targeting the essential WalR response regulator.

18 August 2018

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Walkmycin B targets WalK (YycG), a histidine kinase essential for bacterial cell growth.

18 August 2018

1 reference

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Targeting two-component signal transduction: a novel drug discovery system.

18 August 2018

1 reference

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The essential YycFG two-component system controls cell wall metabolism in Bacillus subtilis.

18 August 2018

1 reference

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Isolation and characterization of inhibitors of the essential histidine kinase, YycG in Bacillus subtilis and Staphylococcus aureus.

18 August 2018

1 reference

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Genes controlled by the essential YycG/YycF two-component system of Bacillus subtilis revealed through a novel hybrid regulator approach

18 August 2018

1 reference

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Antibacterial agents that inhibit histidine protein kinase YycG of Bacillus subtilis

18 August 2018

1 reference

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Demonstration of dimer formation of the cytoplasmic domain of a transmembrane osmosensor protein, EnvZ, of Escherichia coli using Ni-histidine tag affinity chromatography

18 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22526318

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1128/AAC.06467-11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22526318%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

1 reference

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29 January 2020

1 reference