Ca(2+)-synaptotagmin directly regulates t-SNARE function during reconstituted membrane fusion. (Q41791620)

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18 January 2020

title

Ca(2+)-synaptotagmin directly regulates t-SNARE function during reconstituted membrane fusion (English)

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Synaptosomal-associated protein 25

18 January 2020

main subject

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Vesicle-associated membrane protein 2

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Syntaxin YPL232W

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Sec9p YGR009C

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author

Edwin Chapman

4

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18 January 2020

author name string

Akhil Bhalla

1

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18 January 2020

Michael C Chicka

2

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18 January 2020

Ward C Tucker

3

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18 January 2020

publication date

26 March 2006

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Nature Structural & Molecular Biology

18 January 2020

published in

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18 January 2020

volume

13

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18 January 2020

page(s)

323-330

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18 January 2020

issue

4

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https://scigraph.springernature.com/pub.10.1038/nsmb1076

18 January 2020

exact match

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cites work

Mechanisms of intracellular protein transport

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SNARE-mediated membrane fusion

21 January 2018

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Membrane fusion and exocytosis

21 January 2018

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Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 A resolution

21 January 2018

1 reference

The synaptic SNARE complex is a parallel four-stranded helical bundle

21 January 2018

1 reference

Structural organization of the synaptic exocytosis core complex

21 January 2018

1 reference

Structure and conformational changes in NSF and its membrane receptor complexes visualized by quick-freeze/deep-etch electron microscopy

21 January 2018

1 reference

SNAREpins: minimal machinery for membrane fusion

21 January 2018

1 reference

Folding intermediates of SNARE complex assembly

21 January 2018

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Sequential SNARE assembly underlies priming and triggering of exocytosis.

21 January 2018

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Regulation of membrane fusion by the membrane-proximal coil of the t-SNARE during zippering of SNAREpins

21 January 2018

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SNARE assembly and membrane fusion, a kinetic analysis

21 January 2018

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Compartmental specificity of cellular membrane fusion encoded in SNARE proteins

21 January 2018

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SNARE complex formation is triggered by Ca2+ and drives membrane fusion

21 January 2018

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Synaptotagmin I, a Ca2+ sensor for neurotransmitter release

21 January 2018

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Synaptotagmin: a Ca(2+) sensor that triggers exocytosis?

21 January 2018

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Identification of a synaptic vesicle-specific membrane protein with a wide distribution in neuronal and neurosecretory tissue

21 January 2018

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Phospholipid binding by a synaptic vesicle protein homologous to the regulatory region of protein kinase C

21 January 2018

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Syntaxin: a synaptic protein implicated in docking of synaptic vesicles at presynaptic active zones

21 January 2018

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A protein assembly-disassembly pathway in vitro that may correspond to sequential steps of synaptic vesicle docking, activation, and fusion

21 January 2018

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Fusion pore dynamics are regulated by synaptotagmin*t-SNARE interactions.

21 January 2018

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Ca2+ regulates the interaction between synaptotagmin and syntaxin 1.

21 January 2018

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Binding of the synaptic vesicle v-SNARE, synaptotagmin, to the plasma membrane t-SNARE, SNAP-25, can explain docked vesicles at neurotoxin-treated synapses

21 January 2018

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Synaptotagmin: a calcium sensor on the synaptic vesicle surface.

21 January 2018

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PIP2 increases the speed of response of synaptotagmin and steers its membrane-penetration activity toward the plasma membrane.

21 January 2018

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Synaptotagmin I functions as a calcium regulator of release probability

21 January 2018

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Examining synaptotagmin 1 function in dense core vesicle exocytosis under direct control of Ca2+

21 January 2018

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Reconstitution of Ca2+-regulated membrane fusion by synaptotagmin and SNAREs.

21 January 2018

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Synaptotagmin isoforms couple distinct ranges of Ca2+, Ba2+, and Sr2+ concentration to SNARE-mediated membrane fusion

21 January 2018

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C2A activates a cryptic Ca(2+)-triggered membrane penetration activity within the C2B domain of synaptotagmin I.

21 January 2018

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Visualization of synaptotagmin I oligomers assembled onto lipid monolayers.

21 January 2018

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Sec9 is a SNAP-25-like component of a yeast SNARE complex that may be the effector of Sec4 function in exocytosis

21 January 2018

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SNARE-driven, 25-millisecond vesicle fusion in vitro

21 January 2018

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Calmodulin and lipid binding to synaptobrevin regulates calcium-dependent exocytosis

21 January 2018

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SNARE assembly and disassembly exhibit a pronounced hysteresis

21 January 2018

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Hemifusion in SNARE-mediated membrane fusion

21 January 2018

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Selective phosphatidylethanolamine translocation across vesicle membranes using synthetic translocases.

21 January 2018

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Pore formation and translocation of melittin

21 January 2018

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Ca2+-dependent synaptotagmin binding to SNAP-25 is essential for Ca2+-triggered exocytosis

21 January 2018

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Unexpected Ca2+-binding properties of synaptotagmin 9

21 January 2018

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Sr2+ binding to the Ca2+ binding site of the synaptotagmin 1 C2B domain triggers fast exocytosis without stimulating SNARE interactions

21 January 2018

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Membrane fusion induced by neuronal SNAREs transits through hemifusion.

21 January 2018

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SNAREs can promote complete fusion and hemifusion as alternative outcomes

21 January 2018

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Specificity and regulation of a synaptic vesicle docking complex

21 January 2018

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Different domains of synaptotagmin control the choice between kiss-and-run and full fusion.

21 January 2018

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Synaptotagmin modulation of fusion pore kinetics in regulated exocytosis of dense-core vesicles

21 January 2018

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Transmembrane segments of syntaxin line the fusion pore of Ca2+-triggered exocytosis.

21 January 2018

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The C2B domain of synaptotagmin is a Ca(2+)-sensing module essential for exocytosis

21 January 2018

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A novel function for the second C2 domain of synaptotagmin. Ca2+-triggered dimerization.

21 January 2018

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Human cDNA clones encoding two different isoforms of the nerve terminal protein SNAP-25

21 January 2018

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Trans-SNARE pairing can precede a hemifusion intermediate in intracellular membrane fusion

21 January 2018

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The length of the flexible SNAREpin juxtamembrane region is a critical determinant of SNARE-dependent fusion

21 January 2018

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Mutations in the effector binding loops in the C2A and C2B domains of synaptotagmin I disrupt exocytosis in a nonadditive manner

31 March 2020

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Kinetics of synaptotagmin responses to Ca2+ and assembly with the core SNARE complex onto membranes

31 March 2020

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synaptotagmin mutants reveal essential functions for the C2B domain in Ca2+-triggered fusion and recycling of synaptic vesicles in vivo

31 March 2020

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Synaptic vesicle membrane fusion complex: action of clostridial neurotoxins on assembly

31 March 2020

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Fluorescence assay for phospholipid membrane asymmetry

31 March 2020

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Synaptotagmin-Ca2+ triggers two sequential steps in regulated exocytosis in rat PC12 cells: fusion pore opening and fusion pore dilation

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NSMB1076

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16565726%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

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