Hax1-mediated processing of HtrA2 by Parl allows survival of lymphocytes and neurons (Q41791615)

10 October 2017

Hax1-mediated processing of HtrA2 by Parl allows survival of lymphocytes and neurons (English)

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Presenilin associated, rhomboid-like

10 October 2017

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GOA release 2020-03-11

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GOA release 2020-03-11

HtrA serine peptidase 2

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GOA release 2020-03-11

3

Kelli Boyd

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10 October 2017

Jyh-Rong Chao

1

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10 October 2017

Evan Parganas

2

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10 October 2017

Cheol Yi Hong

4

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10 October 2017

Joseph T Opferman

5

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10 October 2017

James N Ihle

6

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10 October 2017

language of work or name

English

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publication date

20 February 2008

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10 October 2017

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10 October 2017

452

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10 October 2017

7183

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10 October 2017

98-102

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https://scigraph.springernature.com/pub.10.1038/nature06604

10 October 2017

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cites work

Cytokine receptor signalling

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https://api.crossref.org/works/10.1038%2FNATURE06604

7 January 2021

K15 protein of Kaposi's sarcoma-associated herpesvirus is latently expressed and binds to HAX-1, a protein with antiapoptotic function

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06604

7 January 2021

HAX1 deficiency causes autosomal recessive severe congenital neutropenia (Kostmann disease)

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06604

7 January 2021

Severe developmental delay and epilepsy in a Japanese patient with severe congenital neutropenia due to HAX1 deficiency.

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https://api.crossref.org/works/10.1038%2FNATURE06604

7 January 2021

Infantile genetic agranulocytosis, morbus Kostmann: presentation of six cases from the original "Kostmann family" and a review

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https://api.crossref.org/works/10.1038%2FNATURE06604

7 January 2021

Loss of Omi mitochondrial protease activity causes the neuromuscular disorder of mnd2 mutant mice

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https://api.crossref.org/works/10.1038%2FNATURE06604

7 January 2021

Neuroprotective role of the Reaper-related serine protease HtrA2/Omi revealed by targeted deletion in mice

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https://api.crossref.org/works/10.1038%2FNATURE06604

7 January 2021

Regulation of HAX-1 anti-apoptotic protein by Omi/HtrA2 protease during cell death

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https://api.crossref.org/works/10.1038%2FNATURE06604

7 January 2021

Structural insights into the pro-apoptotic function of mitochondrial serine protease HtrA2/Omi

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https://api.crossref.org/works/10.1038%2FNATURE06604

7 January 2021

Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1-dependent cristae remodeling

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06604

7 January 2021

HtrA2/Omi, a sheep in wolf's clothing

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06604

7 January 2021

OPA1 controls apoptotic cristae remodeling independently from mitochondrial fusion

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06604

7 January 2021

Growth factor withdrawal and apoptosis: the middle game

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06604

7 January 2021

BAX is required for neuronal death after trophic factor deprivation and during development

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https://api.crossref.org/works/10.1038%2FNATURE06604

7 January 2021

Placement of the BCL2 family member BAX in the death pathway of sympathetic neurons activated by trophic factor deprivation.

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https://api.crossref.org/works/10.1038%2FNATURE06604

7 January 2021

Widespread elimination of naturally occurring neuronal death in Bax-deficient mice

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https://api.crossref.org/works/10.1038%2FNATURE06604

7 January 2021

The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues

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https://api.crossref.org/works/10.1038%2FNATURE06604

7 January 2021

Survival factor-induced extracellular signal-regulated kinase phosphorylates BIM, inhibiting its association with BAX and proapoptotic activity.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06604

7 January 2021

Extracellular signal-regulated kinases 1/2 are serum-stimulated "Bim(EL) kinases" that bind to the BH3-only protein Bim(EL) causing its phosphorylation and turnover

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06604

7 January 2021

Phosphorylation of Bim-EL by Erk1/2 on serine 69 promotes its degradation via the proteasome pathway and regulates its proapoptotic function.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06604

7 January 2021

Phosphorylation of the pro-apoptotic protein Bim in lymphocytes is associated with protection from apoptosis

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https://api.crossref.org/works/10.1038%2FNATURE06604

7 January 2021

Conformation of the Bax C-terminus regulates subcellular location and cell death

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https://api.crossref.org/works/10.1038%2FNATURE06604

7 January 2021

Movement of Bax from the cytosol to mitochondria during apoptosis

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https://api.crossref.org/works/10.1038%2FNATURE06604

7 January 2021

The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase PINK1.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE06604

7 January 2021

Jak2 is essential for signaling through a variety of cytokine receptors

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https://api.crossref.org/works/10.1038%2FNATURE06604

7 January 2021

Identifiers

DOI

10.1038/NATURE06604

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Dimensions Publication ID

10 October 2017

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