Pegylated derivatives of recombinant human arginase (rhArg1) for sustained in vivo activity in cancer therapy: preparation, characterization and analysis of their pharmacodynamics in vivo and in vitro and action upon hepatocellular carcinoma cell (H (Q41779635)

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scientific article published on 17 April 2009

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English	Pegylated derivatives of recombinant human arginase (rhArg1) for sustained in vivo activity in cancer therapy: preparation, characterization and analysis of their pharmacodynamics in vivo and in vitro and action upon hepatocellular carcinoma cell (H	scientific article published on 17 April 2009

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scholarly article

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26 January 2020

Pegylated derivatives of recombinant human arginase (rhArg1) for sustained in vivo activity in cancer therapy: preparation, characterization and analysis of their pharmacodynamics in vivo and in vitro and action upon hepatocellular carcinoma cell (HCC) (English)

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26 January 2020

pharmacodynamics

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1

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26 January 2020

Yun-Chung Leung

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26 January 2020

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Wai-Man Lam

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26 January 2020

Tin-Lun Lam

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26 January 2020

Hiu-Chi Chong

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26 January 2020

Pui-Kin So

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26 January 2020

Sui-Yi Kwok

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26 January 2020

Simon Arnold

7

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26 January 2020

Paul Ning-Man Cheng

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26 January 2020

Denys N Wheatley

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26 January 2020

Wai-Hung Lo

10

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26 January 2020

publication date

17 April 2009

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26 January 2020

Cancer Cell International

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26 January 2020

9

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26 January 2020

9

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26 January 2020

Structure and function of arginases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2679726

6 June 2018

Controlling cancer by restricting arginine availability--arginine-catabolizing enzymes as anticancer agents

1 reference

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6 June 2018

Pegvisomant Pfizer/Sensus

1 reference

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6 June 2018

In vivo efficacy of recombinant methioninase is enhanced by the combination of polyethylene glycol conjugation and pyridoxal 5'-phosphate supplementation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2679726

6 June 2018

Effect of pegylation on pharmaceuticals

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2679726

6 June 2018

Arginine deprivation, growth inhibition and tumour cell death: 2. Enzymatic degradation of arginine in normal and malignant cell cultures

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2679726

6 June 2018

Pegylated interferons.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2679726

6 June 2018

Chemistry for peptide and protein PEGylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2679726

6 June 2018

Pegylation: a novel process for modifying pharmacokinetics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2679726

6 June 2018

Arginine deiminase inhibits proliferation of human leukemia cells more potently than asparaginase by inducing cell cycle arrest and apoptosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2679726

6 June 2018

Expression of human liver arginase in Escherichia coli. Purification and properties of the product

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2679726

6 June 2018

In vivo anti-tumor activity of arginine deiminase purified from Mycoplasma arginini

1 reference

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6 June 2018

Preparation of a non-immunogenic arginase by the covalent attachment of polyethylene glycol

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2679726

6 June 2018

Pegylated arginine deiminase treatment of patients with metastatic melanoma: results from phase I and II studies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2679726

18 August 2018

Remission of hepatocellular carcinoma with arginine depletion induced by systemic release of endogenous hepatic arginase due to transhepatic arterial embolisation, augmented by high-dose insulin: arginase as a potential drug candidate for hepatocell

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2679726

18 August 2018

Pegylated arginine deiminase treatment of patients with unresectable hepatocellular carcinoma: results from phase I/II studies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2679726

18 August 2018

Pegylated arginine deiminase (ADI-SS PEG20,000 mw) inhibits human melanomas and hepatocellular carcinomas in vitro and in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2679726

18 August 2018

Poly(ethylene glycol) (PEG) conjugated arginine deiminase: effects of PEG formulations on its pharmacological properties

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2679726

18 August 2018

Attachment of degradable poly(ethylene glycol) to proteins has the potential to increase therapeutic efficacy

1 reference

https://pubmed.ncbi.nlm.nih.gov/19374748

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cancer therapy with chemically modified enzymes. II. The therapeutic effectiveness of arginase, and arginase modified by the covalent attachment of polyethylene glycol, on the taper liver tumor and the L5178Y murine leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/19374748

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Relationship between molecular mass and duration of activity of polyethylene glycol conjugated granulocyte colony-stimulating factor mutein

1 reference

https://pubmed.ncbi.nlm.nih.gov/19374748

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Estimation of protein secondary structure from circular dichroism spectra: inclusion of denatured proteins with native proteins in the analysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19374748

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Purification and properties of human erythrocyte arginase

1 reference

https://pubmed.ncbi.nlm.nih.gov/19374748

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Site-directed pegylation of recombinant interleukin-2 at its glycosylation site

1 reference

https://pubmed.ncbi.nlm.nih.gov/19374748

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antitumor activity of tumor necrosis factor-alpha conjugated with polyvinylpyrrolidone on solid tumors in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/19374748

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Studies on the mechanism of tumor inhibition by L-asparaginase. Effects of the enzyme on asparagine levels in the blood, normal tissues, and 6C3HED lymphomas of mice: differences in asparagine formation and utilization in asparaginase-sensitive and

1 reference

https://pubmed.ncbi.nlm.nih.gov/19374748

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Manganese-dependent inhibition of human liver arginase by borate

1 reference

https://pubmed.ncbi.nlm.nih.gov/19374748

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pegylated recombinant human arginase (rhArg-peg5,000mw) inhibits the in vitro and in vivo proliferation of human hepatocellular carcinoma through arginine depletion

1 reference

https://pubmed.ncbi.nlm.nih.gov/19374748

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1186/1475-2867-9-9

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Europe PubMed Central

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26 January 2020

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26 January 2020

PubMed publication ID

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26 January 2020

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