A 13C-n.m.r. investigation of the ionizations within an inhibitor--alpha-chymotrypsin complex. Evidence that both alpha-chymotrypsin and trypsin stabilize a hemiketal oxyanion by similar mechanisms (Q41763599)

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scientific article published on March 1989

Language	Label	Description	Also known as
English	A 13C-n.m.r. investigation of the ionizations within an inhibitor--alpha-chymotrypsin complex. Evidence that both alpha-chymotrypsin and trypsin stabilize a hemiketal oxyanion by similar mechanisms	scientific article published on March 1989

Statements

scholarly article

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

A 13C-n.m.r. investigation of the ionizations within an inhibitor--alpha-chymotrypsin complex. Evidence that both alpha-chymotrypsin and trypsin stabilize a hemiketal oxyanion by similar mechanisms (English)

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

author name string

Finucane MD

1

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

Hudson EA

2

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

Malthouse JP

3

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

language of work or name

0 references

publication date

1 March 1989

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

Biochemical Journal

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Europe PubMed Central

PMC publication ID

9 October 2017

258

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

3

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

853-859

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

Direct determination of the protonation states of aspartic acid-102 and histidine-57 in the tetrahedral intermediate of the serine proteases: neutron structure of trypsin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1138442

6 June 2018

Current problems in mechanistic studies of serine and cysteine proteinases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1138442

6 June 2018

Transition-state stabilization at the oxyanion binding sites of serine and thiol proteinases: hydrolyses of thiono and oxygen esters

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1138442

6 June 2018

A Proton-Magnetic-Resonance Study of N-Trifluoroacetyl-l-alanyl-l-phenylalaninal Binding to alpha-Chymotrypsin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1138442

6 June 2018

Structure of crystalline -chymotrypsin. II. A preliminary report including a hypothesis for the activation mechanism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1138442

6 June 2018

High resolution nuclear magnetic resonance studies of the active site of chymotrypsin. II. Polarization of histidine 57 by substrate analogues and competitive inhibitors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1138442

6 June 2018

Changes in the tertiary structure of alpha-chymotrypsin with change in pH: p4 4.2-6.7.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1138442

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The mechanism of the aminolysis of acetate esters.

1 reference

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6 June 2018

Affinity labelling of proteinases with tryptic specificity by peptides with C-terminal lysine chloromethyl ketone

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1138442

6 June 2018

Studies of the activity of chymotrypsin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1138442

6 June 2018

A 13C-n.m.r. investigation of ionizations within a trypsin-inhibitor complex. Evidence that the pKa of histidine-57 is raised by interaction with the hemiketal oxyanion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1138442

6 June 2018

13C NMR study of the ionizations within a trypsin-chloromethyl ketone inhibitor complex.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1138442

6 June 2018

Site-directed mutagenesis and the role of the oxyanion hole in subtilisin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1138442

6 June 2018

Subtilisin--an enzyme designed to be engineered

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1138442

6 June 2018

Evidence for hemiacetal formation between N-acyl-L-phenylalaninals and .alpha.-chymotrypsin by cross-saturation nuclear magnetic resonance spectroscopy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1138442

6 June 2018

Serine Proteases: Structure and Mechanism of Catalysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1138442

6 June 2018

Do cleavages of amides by serine proteases occur through a stepwise pathway involving tetrahedral intermediates?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1138442

6 June 2018

Implication of an Ionizing Group in the Control of Conformation and Activity of Chymotrypsin

1 reference

https://pubmed.ncbi.nlm.nih.gov/2730570

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

THE IDENTIFICATION OF THE HISTIDINE RESIDUE AT THE ACTIVE CENTER OF CHYMOTRYPSIN

1 reference

https://pubmed.ncbi.nlm.nih.gov/2730570

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of the histidine residue at the active center of trypsin labelled by TLCK

1 reference

https://pubmed.ncbi.nlm.nih.gov/2730570

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Studies on the Reaction of Chymotrypsin and L-1-Chloro-3-tosylamido-4-phenyl-2-butanone

1 reference

https://pubmed.ncbi.nlm.nih.gov/2730570

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Inhibition of chymotrypsins A4 and B with chloromethyl ketone reagents

1 reference

https://pubmed.ncbi.nlm.nih.gov/2730570

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Conformation of the high pH form of chymotrypsin

1 reference

https://pubmed.ncbi.nlm.nih.gov/2730570

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Binding interactions between two ligands and a monomeric protein. Study on indole, protons and chymotrypsin

1 reference

https://pubmed.ncbi.nlm.nih.gov/2730570

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sedimentation of chemically modified chymotrypsin

1 reference

https://pubmed.ncbi.nlm.nih.gov/2730570

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure of crystalline alpha-chymotrypsin. IV. The structure of indoleacryloyl-alpha-chyotrypsin and its relevance to the hydrolytic mechanism of the enzyme

1 reference

https://pubmed.ncbi.nlm.nih.gov/2730570

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activity and conformation of the alkaline form of δ-chymotrypsin studied by the specific acylation of isoleucine-16

1 reference

https://pubmed.ncbi.nlm.nih.gov/2730570

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Equilibrium and rate constants for the interconversion of two conformations of -chymotrypsin. The existence of a catalytically inactive conformation at neutral p H

1 reference

https://pubmed.ncbi.nlm.nih.gov/2730570

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regeneration of methionyl residues from their sulfonium salts in peptides and proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/2730570

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High resolution nuclear magnetic resonance studies of the active site of chymotrypsin. I. The hydrogen bonded protons of the "charge relay" system

1 reference

https://pubmed.ncbi.nlm.nih.gov/2730570

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for hemiketals as intermediates in the inactivation of serine proteinases with halomethyl ketones

1 reference

https://pubmed.ncbi.nlm.nih.gov/2730570

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Complex of alpha-chymotrypsin and N-acetyl-L-leucyl-L-phenylalanyl trifluoromethyl ketone: structural studies with NMR spectroscopy

1 reference

https://pubmed.ncbi.nlm.nih.gov/2730570

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acylation of the enzymatic site of delta-chymotrypsin by esters, acid anhydrides, and acid chlorides

1 reference

https://pubmed.ncbi.nlm.nih.gov/2730570

12 December 2020

based on heuristic

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The spectrophotometric determination of the operational normality of an alpha-chymotrypsin solution

1 reference

https://pubmed.ncbi.nlm.nih.gov/2730570

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Direct evidence for the presence of histidine in the active center of chymotrypsin

1 reference

https://pubmed.ncbi.nlm.nih.gov/2730570

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Investigations of the chymotrypsin-catalyzed hydrolysis of specific substrates. I. The pH dependence of the catalytic hydrolysis of N-acetyl-L-tryptophanamide by three forms of the enzyme at alkaline pH

1 reference

https://pubmed.ncbi.nlm.nih.gov/2730570

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1042/BJ2580853

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

9 October 2017

ResearchGate publication ID

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