Identification of Mithramycin Analogues with Improved Targeting of the EWS-FLI1 Transcription Factor (Q41739827)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26979396%20AND%20SRC:MED&resulttype=core&format=json

11 March 2020

title

Identification of Mithramycin Analogues with Improved Targeting of the EWS-FLI1 Transcription Factor (English)

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11 March 2020

11

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11 March 2020

Malcolm A Smith

12

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18

Lee J Helman

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11 March 2020

10

Stephen L Lessnick

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20

Patrick J Grohar

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11 March 2020

author name string

Christy L Osgood

1

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11 March 2020

Nichole Maloney

2

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11 March 2020

Christopher G Kidd

3

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11 March 2020

Susan Kitchen-Goosen

4

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11 March 2020

Laura Segars

5

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11 March 2020

Meti Gebregiorgis

6

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11 March 2020

Girma M Woldemichael

7

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11 March 2020

Min He

8

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11 March 2020

Savita Sankar

9

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11 March 2020

Lisa Turner

13

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11 March 2020

Zachary B Madaj

14

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11 March 2020

Mary E Winn

15

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11 March 2020

Luz-Elena Núñez

16

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11 March 2020

Javier González-Sabín

17

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11 March 2020

Francisco Morís

19

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11 March 2020

language of work or name

English

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publication date

15 March 2016

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11 March 2020

published in

Clinical Cancer Research

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11 March 2020

volume

22

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11 March 2020

issue

16

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11 March 2020

page(s)

4105-4118

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Expanding the Chemical Diversity of the Antitumoral Compound Mithramycin by Combinatorial Biosynthesis and Biocatalysis: The Quest for Mithralogs with Improved Therapeutic Window

11 March 2020

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Tumoral TP53 and/or CDKN2A alterations are not reliable prognostic biomarkers in patients with localized Ewing sarcoma: a report from the Children's Oncology Group

6 June 2018

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EWS-FLI1 utilizes divergent chromatin remodeling mechanisms to directly activate or repress enhancer elements in Ewing sarcoma

6 June 2018

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Reversible LSD1 inhibition interferes with global EWS/ETS transcriptional activity and impedes Ewing sarcoma tumor growth.

6 June 2018

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Drug-induced endoplasmic reticulum and oxidative stress responses independently sensitize toward TNFα-mediated hepatotoxicity

6 June 2018

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Hypoxia shifts activity of neuropeptide Y in Ewing sarcoma from growth-inhibitory to growth-promoting effects.

6 June 2018

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Dual targeting of EWS-FLI1 activity and the associated DNA damage response with trabectedin and SN38 synergistically inhibits Ewing sarcoma cell growth

6 June 2018

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Oncogenic ETS fusions deregulate E2F3 target genes in Ewing sarcoma and prostate cancer

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Differential disruption of EWS-FLI1 binding by DNA-binding agents

6 June 2018

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Lysyl oxidase is downregulated by the EWS/FLI1 oncoprotein and its propeptide domain displays tumor supressor activities in Ewing sarcoma cells

6 June 2018

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Mechanism and relevance of EWS/FLI-mediated transcriptional repression in Ewing sarcoma

6 June 2018

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Randomized controlled trial of interval-compressed chemotherapy for the treatment of localized Ewing sarcoma: a report from the Children's Oncology Group

6 June 2018

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A novel mithramycin analogue with high antitumor activity and less toxicity generated by combinatorial biosynthesis

6 June 2018

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Small-molecule screen identifies modulators of EWS/FLI1 target gene expression and cell survival in Ewing's sarcoma

6 June 2018

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Tumor-specific retargeting of an oncogenic transcription factor chimera results in dysregulation of chromatin and transcription.

6 June 2018

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STEAP1 is associated with the invasive and oxidative stress phenotype of Ewing tumors

6 June 2018

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Identification of an inhibitor of the EWS-FLI1 oncogenic transcription factor by high-throughput screening.

6 June 2018

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Ecteinascidin 743 interferes with the activity of EWS-FLI1 in Ewing sarcoma cells

6 June 2018

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6 June 2018

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6 June 2018

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EWS/FLI and its downstream target NR0B1 interact directly to modulate transcription and oncogenesis in Ewing's sarcoma

6 June 2018

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GSTM4 is a microsatellite-containing EWS/FLI target involved in Ewing's sarcoma oncogenesis and therapeutic resistance

6 June 2018

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A small molecule blocking oncogenic protein EWS-FLI1 interaction with RNA helicase A inhibits growth of Ewing's sarcoma

6 June 2018

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A molecular function map of Ewing's sarcoma

6 June 2018

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The oncogenic EWS-FLI1 protein binds in vivo GGAA microsatellite sequences with potential transcriptional activation function

6 June 2018

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EZH2 is a mediator of EWS/FLI1 driven tumor growth and metastasis blocking endothelial and neuro-ectodermal differentiation

6 June 2018

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Phase II study of intermediate-dose cytarabine in patients with relapsed or refractory Ewing sarcoma: a report from the Children's Oncology Group

6 June 2018

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Microsatellites as EWS/FLI response elements in Ewing's sarcoma

6 June 2018

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6 June 2018

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A transcriptional profiling meta-analysis reveals a core EWS-FLI gene expression signature

6 June 2018

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Signature-based small molecule screening identifies cytosine arabinoside as an EWS/FLI modulator in Ewing sarcoma

6 June 2018

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Caveolin-1 (CAV1) is a target of EWS/FLI-1 and a key determinant of the oncogenic phenotype and tumorigenicity of Ewing's sarcoma cells.

6 June 2018

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Expression profiling of EWS/FLI identifies NKX2.2 as a critical target gene in Ewing's sarcoma

6 June 2018

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The orphan nuclear receptor DAX1 is up-regulated by the EWS/FLI1 oncoprotein and is highly expressed in Ewing tumors

6 June 2018

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Oncogene-targeted antisense oligonucleotides for the treatment of Ewing sarcoma

6 June 2018

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Integrating pharmacology and in vivo cancer models in preclinical and clinical drug development

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4987166

MITHRAMYCIN IN THE TREATMENT OF EMBRYONAL CANCER.

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4987166

MITHRAMYCIN IN THE TREATMENT OF DISSEMINATED CANCER

6 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4987166

Identification of p21WAF1/CIP1 as a direct target of EWS-Fli1 oncogenic fusion protein

6 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4987166

The Id2 gene is a novel target of transcriptional activation by EWS-ETS fusion proteins in Ewing family tumors.

6 June 2018

1 reference

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Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours

6 June 2018

1 reference

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A high content screening assay to predict human drug-induced liver injury during drug discovery

6 June 2018

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A phase 2 trial of trabectedin in children with recurrent rhabdomyosarcoma, Ewing sarcoma and non-rhabdomyosarcoma soft tissue sarcomas: a report from the Children's Oncology Group.

18 August 2018

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EWS-FLI-1 expression triggers a Ewing's sarcoma initiation program in primary human mesenchymal stem cells.

18 August 2018

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Treatment of metastatic Ewing sarcoma/primitive neuroectodermal tumor of bone: evaluation of increasing the dose intensity of chemotherapy--a report from the Children's Oncology Group

18 August 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4987166

NR0B1 is required for the oncogenic phenotype mediated by EWS/FLI in Ewing's sarcoma

18 August 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4987166

Addition of ifosfamide and etoposide to standard chemotherapy for Ewing's sarcoma and primitive neuroectodermal tumor of bone

18 August 2018

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10.1158/1078-0432.CCR-15-2624

18 August 2018

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26979396%20AND%20SRC:MED&resulttype=core&format=json

11 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26979396%20AND%20SRC:MED&resulttype=core&format=json

11 March 2020

PubMed publication ID

26979396

1 reference