Hypoxia-inducible factor 1 and the molecular physiology of oxygen homeostasis (Q41730288)

8 October 2017

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title

Hypoxia-inducible factor 1 and the molecular physiology of oxygen homeostasis (English)

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8 October 2017

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1

G L Semenza

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8 October 2017

1 March 1998

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8 October 2017

Translational Research

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8 October 2017

131

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8 October 2017

3

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8 October 2017

207-214

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A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation

8 October 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2143%2898%2990091-9

Effect of protein kinase and phosphatase inhibitors on expression of hypoxia-inducible factor 1.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2143%2898%2990091-9

Effect of altered redox states on expression and DNA-binding activity of hypoxia-inducible factor 1.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2143%2898%2990091-9

Purification and characterization of hypoxia-inducible factor 1

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2143%2898%2990091-9

The Drosophila single-minded gene encodes a helix-loop-helix protein that acts as a master regulator of CNS midline development

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2143%2898%2990091-9

Cloning of a Factor Required for Activity of the Ah (Dioxin) Receptor

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2143%2898%2990091-9

Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2143%2898%2990091-9

Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2143%2898%2990091-9

Hypoxia Response Elements in the Aldolase A, Enolase 1, and Lactate Dehydrogenase A Gene Promoters Contain Essential Binding Sites for Hypoxia-inducible Factor 1

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2143%2898%2990091-9

Nucleotide sequence, chromosomal assignment and mRNA expression of mouse hypoxia-inducible factor-1 alpha

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0022-2143%2898%2990091-9

In vivo expression of mRNAs encoding hypoxia-inducible factor 1

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0022-2143%2898%2990091-9

Functional interference between hypoxia and dioxin signal transduction pathways: competition for recruitment of the Arnt transcription factor

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0022-2143%2898%2990091-9

Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its alpha subunit

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2143%2898%2990091-9

Transactivation and inhibitory domains of hypoxia-inducible factor 1alpha. Modulation of transcriptional activity by oxygen tension

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2143%2898%2990091-9

Induction of phosphoglycerate kinase 1 gene expression by hypoxia. Roles of Arnt and HIF1alpha

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2143%2898%2990091-9

Activation of Hypoxia-inducible Factor-1; Definition of Regulatory Domains within the α Subunit

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2143%2898%2990091-9

Regulation of the erythropoietin gene: evidence that the oxygen sensor is a heme protein

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2143%2898%2990091-9

Cobalt and desferrioxamine reveal crucial members of the oxygen sensing pathway in HepG2 cells

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0022-2143%2898%2990091-9

Cobalt chloride and desferrioxamine antagonize the inhibition of erythropoietin production by reactive oxygen species.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2143%2898%2990091-9

Oxygen regulated gene expression: erythropoietin as a model system

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2143%2898%2990091-9

Diphenylene iodonium inhibits the induction of erythropoietin and other mammalian genes by hypoxia. Implications for the mechanism of oxygen sensing

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2143%2898%2990091-9

Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2143%2898%2990091-9

Hypoxia-inducible Factor-1 Mediates Transcriptional Activation of the Heme Oxygenase-1 Gene in Response to Hypoxia

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2143%2898%2990091-9

A hypoxia-responsive element mediates a novel pathway of activation of the inducible nitric oxide synthase promoter

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2143%2898%2990091-9

Hypoxia and mitochondrial inhibitors regulate expression of glucose transporter-1 via distinct Cis-acting sequences

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2143%2898%2990091-9

Hypoxic Regulation of Lactate Dehydrogenase A

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2143%2898%2990091-9

Absolute requirement of aryl hydrocarbon receptor nuclear translocator protein for gene activation by hypoxia

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2143%2898%2990091-9

The role of the aryl hydrocarbon receptor nuclear translocator (ARNT) in hypoxic induction of gene expression. Studies in ARNT-deficient cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2143%2898%2990091-9

Transcriptional regulation by hypoxia-inducible factor 1 molecular mechanisms of oxygen homeostasis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2143%2898%2990091-9

Hypoxia regulates vascular endothelial growth factor gene expression in endothelial cells. Identification of a 5' enhancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2143%2898%2990091-9

Neuroprotection from ischemic brain injury by hypoxic preconditioning in the neonatal rat.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2143%2898%2990091-9

Acute ischaemic preconditioning and chronic hypoxia independently increase myocardial tolerance to ischaemia

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2143%2898%2990091-9

Angiogenic-induced enhancement of collateral blood flow to ischemic myocardium by vascular endothelial growth factor in dogs

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0022-2143%2898%2990091-9

Upregulation of vascular endothelial growth factor expression induced by myocardial ischaemia: implications for coronary angiogenesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2143%2898%2990091-9

Cardiac hypertrophy in chronically anemic fetal sheep: Increased vascularization is associated with increased myocardial expression of vascular endothelial growth factor and hypoxia-inducible factor 1

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2143%2898%2990091-9

Tumor dormancy in vivo by prevention of neovascularization

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0022-2143%2898%2990091-9

Tumour angiogenesis and prognosis.

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0022-2143%2898%2990091-9

Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0022-2143%2898%2990091-9

Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0022-2143%2898%2990091-9

Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2143%2898%2990091-9

Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2143%2898%2990091-9

Interstitial pH and pO2 gradients in solid tumors in vivo: high-resolution measurements reveal a lack of correlation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2143%2898%2990091-9

Targeting gene expression to hypoxic tumor cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0022-2143%2898%2990091-9

10.1016/S0022-2143(98)90091-9

7 January 2021

Identifiers

DOI

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8 October 2017

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PubMed ID

9523843