Infrequent development of resistance in genotype 1-6 hepatitis C virus-infected subjects treated with sofosbuvir in phase 2 and 3 clinical trials. (Q41722679)

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scientific article published on 28 September 2014

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English	Infrequent development of resistance in genotype 1-6 hepatitis C virus-infected subjects treated with sofosbuvir in phase 2 and 3 clinical trials.	scientific article published on 28 September 2014

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20 February 2020

Infrequent development of resistance in genotype 1-6 hepatitis C virus-infected subjects treated with sofosbuvir in phase 2 and 3 clinical trials (English)

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20 February 2020

phase II clinical trial

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Hepatitis C virus

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Hadas Dvory-Sobol

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Hadas Dvory-Sobol

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David L Wyles

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Evguenia S Svarovskaia

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Hadas Dvory-Sobol

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Neil Parkin

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Christy Hebner

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Viktoria Gontcharova

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Ross Martin

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Wen Ouyang

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Bin Han

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Simin Xu

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Karin Ku

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Sophia Chiu

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Edward Gane

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Ira M Jacobson

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David R Nelson

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Eric Lawitz

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Neby Bekele

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Diana Brainard

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William T Symonds

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John G McHutchison

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Michael D Miller

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Hongmei Mo

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28 September 2014

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Clinical Infectious Diseases

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1666-1674

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20 February 2020

Global epidemiology of hepatitis C virus infection: new estimates of age-specific antibody to HCV seroprevalence

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21 January 2018

Expanded classification of hepatitis C virus into 7 genotypes and 67 subtypes: updated criteria and genotype assignment web resource

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21 January 2018

Hepatitis C virus: standard-of-care treatment

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Review of direct-acting antiviral agents for the treatment of chronic hepatitis C.

1 reference

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Telaprevir for previously treated chronic HCV infection

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Telaprevir for previously untreated chronic hepatitis C virus infection

1 reference

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Boceprevir for untreated chronic HCV genotype 1 infection

1 reference

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21 January 2018

Boceprevir for previously treated chronic HCV genotype 1 infection

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Simeprevir with pegylated interferon alfa 2a or 2b plus ribavirin in treatment-naive patients with chronic hepatitis C virus genotype 1 infection (QUEST-2): a randomised, double-blind, placebo-controlled phase 3 trial

1 reference

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21 January 2018

Simeprevir with pegylated interferon alfa 2a plus ribavirin in treatment-naive patients with chronic hepatitis C virus genotype 1 infection (QUEST-1): a phase 3, randomised, double-blind, placebo-controlled trial

1 reference

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21 January 2018

Sofosbuvir with pegylated interferon alfa-2a and ribavirin for treatment-naive patients with hepatitis C genotype-1 infection (ATOMIC): an open-label, randomised, multicentre phase 2 trial

1 reference

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21 January 2018

Sofosbuvir for hepatitis C genotype 2 or 3 in patients without treatment options

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Sofosbuvir for previously untreated chronic hepatitis C infection

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Current and future therapies for hepatitis C virus infection

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New hepatitis C virus (HCV) drugs and the hope for a cure: concepts in anti-HCV drug development

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Evolution of treatment-emergent resistant variants in telaprevir phase 3 clinical trials

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Genotypic and phenotypic analysis of variants resistant to hepatitis C virus nonstructural protein 5A replication complex inhibitor BMS-790052 in humans: in vitro and in vivo correlations.

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Antiviral therapy of hepatitis C in 2014: do we need resistance testing?

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Sofosbuvir in combination with peginterferon alfa-2a and ribavirin for non-cirrhotic, treatment-naive patients with genotypes 1, 2, and 3 hepatitis C infection: a randomised, double-blind, phase 2 trial

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Nucleotide polymerase inhibitor sofosbuvir plus ribavirin for hepatitis C.

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Characterization of resistance to non-obligate chain-terminating ribonucleoside analogs that inhibit hepatitis C virus replication in vitro

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Inhibition of hepatitis C replicon RNA synthesis by beta-D-2'-deoxy-2'-fluoro-2'-C-methylcytidine: a specific inhibitor of hepatitis C virus replication

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General Catalytic Deficiency of Hepatitis C Virus RNA Polymerase with an S282T Mutation and Mutually Exclusive Resistance towards 2'-Modified Nucleotide Analogues

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Natural variation in drug susceptibility to HCV polymerase inhibitors in treatment-naïve HCV patient isolates

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In vivo emergence of a novel mutant L159F/L320F in the NS5B polymerase confers low-level resistance to the HCV polymerase inhibitors mericitabine and sofosbuvir

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Activity of a Potent Hepatitis C Virus Polymerase Inhibitor in the Chimpanzee Model

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Natural polymorphisms associated with resistance to new antivirals against HCV in newly diagnosed HIV-HCV-coinfected patients

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Susceptibility of treatment-naive hepatitis C virus (HCV) clinical isolates to HCV protease inhibitors

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Characterization of Hepatitis C virus resistance from a multiple-dose clinical trial of the novel NS5A inhibitor GS-5885.

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Antiviral activity of the new DAAs for the treatment of hepatitis C virus infection: virology and resistance

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https://pubmed.ncbi.nlm.nih.gov/25266287

12 December 2020

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Phylogeny and molecular evolution of the hepatitis C virus

1 reference

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12 December 2020

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Identifiers

10.1093/CID/CIU697

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20 February 2020

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20 February 2020

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20 February 2020

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