Prenylation of Ras GTPase superfamily proteins and their function in immunobiology. (Q41722127)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9505089%20AND%20SRC:MED&resulttype=core&format=json

10 November 2019

review article

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title

Prenylation of Ras GTPase superfamily proteins and their function in immunobiology (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9505089%20AND%20SRC:MED&resulttype=core&format=json

10 November 2019

author name string

R B Lobell

series ordinal

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9505089%20AND%20SRC:MED&resulttype=core&format=json

10 November 2019

publication date

1 January 1998

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10 November 2019

published in

Advances in Immunology

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9505089%20AND%20SRC:MED&resulttype=core&format=json

10 November 2019

volume

68

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10 November 2019

page(s)

145-189

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Activation of the NADPH oxidase involves the small GTP-binding protein p21rac1

10 November 2019

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Activation of NADPH oxidase involves the dissociation of p21rac from its inhibitory GDP/GTP exchange protein (rhoGDI) followed by its translocation to the plasma membrane.

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Phosphatidic acid as a second messenger in human polymorphonuclear leukocytes. Effects on activation of NADPH oxidase

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Activation of the cellular proto-oncogene product p21Ras by addition of a myristylation signal

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p21ras is modified by a farnesyl isoprenoid

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Calcium-dependent immediate-early gene induction in lymphocytes is negatively regulated by p21Ha-ras

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Cloning and expression of a cDNA encoding the alpha subunit of rat p21ras protein farnesyltransferase

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cDNA cloning and expression of the peptide-binding β subunit of rat p21rasfarnesyltransferase, the counterpart of yeast DPR1/RAM1

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Solubilization, partial purification, and affinity labeling of the membrane-bound isoprenylated protein endoprotease

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Two cytosolic components of the human neutrophil respiratory burst oxidase translocate to the plasma membrane during cell activation

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The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway

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Amino acid substitutions that convert the protein substrate specificity of farnesyltransferase to that of geranylgeranyltransferase type I.

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Activation of mitogen-activated protein kinase kinase by v-Raf in NIH 3T3 cells and in vitro

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Isolation of a novel gene mutated in Wiskott-Aldrich syndrome

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Geranylgeranylation of Rab proteins

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Interaction of Rac with p67phox and regulation of phagocytic NADPH oxidase activity

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The respiratory burst oxidase and the molecular genetics of chronic granulomatous disease

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Purification of a protein palmitoyltransferase that acts on H-Ras protein and on a C-terminal N-Ras peptide

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p190 RhoGAP, the major RasGAP-associated protein, binds GTP directly

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Aberrant function of the Ras-related protein TC21/R-Ras2 triggers malignant transformation.

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FAS-induced apoptosis is mediated via a ceramide-initiated RAS signaling pathway

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Fas-induced programmed cell death is mediated by a Ras-regulated O2- synthesis

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Identification of Ras farnesyltransferase inhibitors by microbial screening

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Requirement for posttranslational processing of Rac GTP-binding proteins for activation of human neutrophil NADPH oxidase

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The role of prenylation in G-protein assembly and function

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Evidence for a catalytic role of zinc in protein farnesyltransferase. Spectroscopy of Co2+-farnesyltransferase indicates metal coordination of the substrate thiolate

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Mitogenic signaling mediated by oxidants in Ras-transformed fibroblasts

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Evidence that farnesyltransferase inhibitors suppress Ras transformation by interfering with Rho activity

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Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane

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Differential expression of the ras gene family in mice

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Disruption of Oncogenic K-Ras4B Processing and Signaling by a Potent Geranylgeranyltransferase I Inhibitor

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Inhibition of Rab3B expression attenuates Ca(2+)-dependent exocytosis in rat anterior pituitary cells

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Function and regulation of ras.

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Mechanistic studies on human platelet isoprenylated protein methyltransferase: farnesylcysteine analogs block platelet aggregation without inhibiting the methyltransferase

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Evidence for Rho-mediated agonist stimulation of phospholipase D in rat1 fibroblasts. Effects of Clostridium botulinum C3 exoenzyme.

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A non-receptor tyrosine kinase that inhibits the GTPase activity of p21cdc42

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The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain

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Activation of phospholipase D and phosphatidylinositol 4-phosphate 5-kinase in HL60 membranes is mediated by endogenous Arf but not Rho

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7 January 2021

Platelet-derived growth factor receptor tyrosine phosphorylation requires protein geranylgeranylation but not farnesylation

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7 January 2021

Selective activation of the JNK signaling cascadeand c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs

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7 January 2021

T cell lines characterize events in the pathogenesis of the Wiskott-Aldrich syndrome

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Complexes of Ras.GTP with Raf-1 and mitogen-activated protein kinase kinase

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G protein gamma subunits contain a 20-carbon isoprenoid

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Endosome dynamics regulated by a Rho protein.

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Prenylation of an interferon-gamma-induced GTP-binding protein: the human guanylate binding protein, huGBP1

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7 January 2021

Regulation and function of the Rho subfamily of small GTPases

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Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

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7 January 2021

GTPases: multifunctional molecular switches regulating vesicular traffic

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7 January 2021

The dynamics of exocytosis in human neutrophils

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7 January 2021

Intracellular application of guanosine-5'-O-(3-thiotriphosphate) induces exocytotic granule fusion in guinea pig eosinophils

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7 January 2021

Exocytotic fusion is activated by Rab3a peptides

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7 January 2021

RT-PCR cloning of Rab3 isoforms expressed in peritoneal mast cells

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7 January 2021

Suppression of yeast geranylgeranyl transferase I defect by alternative prenylation of two target GTPases, Rho1p and Cdc42p

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7 January 2021

Effect of Clostridium difficile toxin B on IgE receptor-mediated signal transduction in rat basophilic leukemia cells: inhibition of phospholipase D activation

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7 January 2021

Characterization of recombinant human farnesyl-protein transferase: cloning, expression, farnesyl diphosphate binding, and functional homology with yeast prenyl-protein transferases

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7 January 2021

T cell activation via the disialoganglioside GD3: analysis of signal transduction

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7 January 2021

Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27

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Functional significance of G protein carboxymethylation

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Functional significance of beta gamma-subunit carboxymethylation for the activation of phospholipase C and phosphoinositide 3-kinase

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Crystal structure of protein farnesyltransferase at 2.25 angstrom resolution

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Purified cytochrome b from human granulocyte plasma membrane is comprised of two polypeptides with relative molecular weights of 91,000 and 22,000

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The regulation and function of p21ras during T-cell activation and growth.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960559-3

7 January 2021

Phosphinyl acid-based bisubstrate analog inhibitors of Ras farnesyl protein transferase

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960559-3

7 January 2021

Rac mediates growth factor-induced arachidonic acid release.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960559-3

7 January 2021

Rab GTPases: master regulators of membrane trafficking

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960559-3

7 January 2021

Rab GDP dissociation inhibitor: putting rab GTPases in the right place.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960559-3

7 January 2021

Carboxyl methylation of Ras-related proteins during signal transduction in neutrophils

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960559-3

7 January 2021

Activation-dependent carboxyl methylation of neutrophil G-protein gamma subunit

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960559-3

7 January 2021

RAM, a gene of yeast required for a functional modification of RAS proteins and for production of mating pheromone a-factor

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960559-3

7 January 2021

Farnesyltransferase inhibition causes morphological reversion of ras-transformed cells by a complex mechanism that involves regulation of the actin cytoskeleton

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960559-3

7 January 2021

G protein-coupled chemoattractant receptors regulate Lyn tyrosine kinase.Shc adapter protein signaling complexes

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960559-3

7 January 2021

A role for Rho in Ras transformation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960559-3

7 January 2021

An essential role for Rac in Ras transformation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960559-3

7 January 2021

Guanine nucleotide exchange factors: activators of the Ras superfamily of proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960559-3

7 January 2021

Association of a Ras-related protein with cytochrome b of human neutrophils

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960559-3

7 January 2021

NF-ATp: a transcription factor required for the co-ordinate induction of several cytokine genes

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960559-3

7 January 2021

Prenylcysteine analogs mimicking the C-terminus of GTP-binding proteins stimulate exocytosis from permeabilized HIT-T15 cells: comparison with the effect of Rab3AL peptide.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960559-3

7 January 2021

Inhibition of purified p21ras farnesyl:protein transferase by Cys-AAX tetrapeptides

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960559-3

7 January 2021

Sequence requirement for peptide recognition by rat brain p21ras protein farnesyltransferase

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960559-3

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960559-3

7 January 2021

Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960559-3

7 January 2021

GTPase activity of Rab5 acts as a timer for endocytic membrane fusion

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960559-3

7 January 2021

Genetic and pharmacological suppression of oncogenic mutations in ras genes of yeast and humans.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960559-3

7 January 2021

Structure and mutational analysis of Rab GDP-dissociation inhibitor

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960559-3

7 January 2021

Crystal structure of the GTPase-activating domain of human p120GAP and implications for the interaction with Ras

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960559-3

7 January 2021

Genomic cloning and characterization of the human thrombin receptor gene. Structural similarity to the proteinase activated receptor-2 gene

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960559-3

7 January 2021

A study of the Influence of mevalonic acid and its metabolites on the morphology of swiss 3T3 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960559-3

7 January 2021

Protein farnesyltransferase and geranylgeranyltransferase share a common alpha subunit

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960559-3

7 January 2021

Deficient geranylgeranylation of Ram/Rab27 in choroideremia.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960559-3

7 January 2021

Mechanism of digeranylgeranylation of Rab proteins. Formation of a complex between monogeranylgeranyl-Rab and Rab escort protein

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960559-3

7 January 2021

GRB2 and phospholipase C-gamma 1 associate with a 36- to 38-kilodalton phosphotyrosine protein after T-cell receptor stimulation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960559-3

7 January 2021

Fluorimetric evaluation of the affinities of isoprenylated peptides for lipid bilayers.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960559-3

7 January 2021

Coexpression of MMTV/v-Ha-ras and MMTV/c-myc genes in transgenic mice: synergistic action of oncogenes in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960559-3

7 January 2021

Geranylgeranylated Rab proteins terminating in Cys-Ala-Cys, but not Cys-Cys, are carboxyl-methylated by bovine brain membranes in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960559-3

7 January 2021

Membrane targeting of the small GTPase Rab9 is accompanied by nucleotide exchange

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960559-3

7 January 2021

Rab7 and Rab9 are recruited onto late endosomes by biochemically distinguishable processes

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960559-3

7 January 2021

ADP-ribosylation of a small size GTP-binding protein in bovine neutrophils by the C3 exoenzyme of Clostridium botulinum and effect on the cell motility

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960559-3

7 January 2021

Activation of Raf as a result of recruitment to the plasma membrane

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960559-3

7 January 2021

On the crawling of animal cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960559-3

7 January 2021

Regulation of the polarization of T cells toward antigen-presenting cells by Ras-related GTPase CDC42

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960559-3

7 January 2021

The C. elegans ksr-1 gene encodes a novel Raf-related kinase involved in Ras-mediated signal transduction

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960559-3

7 January 2021

Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960559-3

7 January 2021

Identification of an isoprenylated cysteine methyl ester hydrolase activity in bovine rod outer segment membranes

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960559-3

7 January 2021

KSR, a novel protein kinase required for RAS signal transduction

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960559-3

7 January 2021

Inhibition of PMA-induced, LFA-1-dependent lymphocyte aggregation by ADP ribosylation of the small molecular weight GTP binding protein, rho.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960559-3

7 January 2021

Ras signaling in tumor necrosis factor-induced apoptosis.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960559-3

7 January 2021

Genetic evidence for in vivo cross-specificity of the CaaX-box protein prenyltransferases farnesyltransferase and geranylgeranyltransferase-I in Saccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960559-3

7 January 2021

Distinct Ras effector pathways are involved in Fc epsilon R1 regulation of the transcriptional activity of Elk-1 and NFAT in mast cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960559-3

7 January 2021

The alpha 6A beta 1 and alpha 6B beta 1 integrin variants signal differences in the tyrosine phosphorylation of paxillin and other proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960559-3

7 January 2021

Membrane association of Rab5 mediated by GDP-dissociation inhibitor and accompanied by GDP/GTP exchange

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960559-3

7 January 2021

Lovastatin inhibits gene expression of type-I scavenger receptor in THP-1 human macrophages

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960559-3

7 January 2021

Complex formation between RAS and RAF and other protein kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960559-3

7 January 2021

Subcellular localization of the small GTPase Rab5a in resting and stimulated human neutrophils.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960559-3

7 January 2021

A non-peptide mimetic of Ras-CAAX: selective inhibition of farnesyltransferase and Ras processing

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960559-3

7 January 2021

Mammalian Ras interacts directly with the serine/threonine kinase Raf

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960559-3

7 January 2021

Selection of potent inhibitors of farnesyl-protein transferase from a synthetic tetrapeptide combinatorial library

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960559-3

7 January 2021

Signal transduction by lymphocyte antigen receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960559-3

7 January 2021

Multiple Ras functions can contribute to mammalian cell transformation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960559-3

7 January 2021

2-substituted piperazines as constrained amino acids. Application to the synthesis of potent, non carboxylic acid inhibitors of farnesyltransferase

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960559-3

7 January 2021

Association of Rab1B with GDP-dissociation inhibitor (GDI) is required for recycling but not initial membrane targeting of the Rab protein

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960559-3

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960559-3

7 January 2021

FMLP activates Ras and Raf in human neutrophils. Potential role in activation of MAP kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960559-3

7 January 2021

Structural insights into the function of the Rab GDI superfamily

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960559-3

7 January 2021

The molecular chaperone Ydj1 is required for the p34CDC28-dependent phosphorylation of the cyclin Cln3 that signals its degradation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960559-3

7 January 2021

Phosphorylation of Raf by ceramide-activated protein kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960559-3

7 January 2021

A protein geranylgeranyltransferase from bovine brain: implications for protein prenylation specificity

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960559-3

7 January 2021

Functional analysis of microphthalmia-associated transcription factor in pigment cell-specific transcription of the human tyrosinase family genes

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960559-3

7 January 2021

Protein prenylation: molecular mechanisms and functional consequences

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960559-3

7 January 2021

Characterization of Ha-ras, N-ras, Ki-Ras4A, and Ki-Ras4B as in vitro substrates for farnesyl protein transferase and geranylgeranyl protein transferase type I

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960559-3

7 January 2021

Kinase suppressor of Ras is ceramide-activated protein kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960559-3

7 January 2021

A small GTP-binding protein, Rho, associates with the platelet-derived growth factor type-beta receptor upon ligand binding.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960559-3

7 January 2021

Isoprenylation mediates direct protein-protein interactions between hepatitis large delta antigen and hepatitis B virus surface antigen.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2808%2960559-3

7 January 2021

10.1016/S0065-2776(08)60559-3

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9505089%20AND%20SRC:MED&resulttype=core&format=json

10 November 2019

1 reference