The inhibition of cell signaling pathways by antitumor ether lipids (Q41714674)

7 October 2017

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title

The inhibition of cell signaling pathways by antitumor ether lipids (English)

1 reference

7 October 2017

G Arthur

1

1 reference

PubMed ID

9487143

7 October 2017

R Bittman

series ordinal

2

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7 October 2017

1 February 1998

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Biochimica et Biophysica Acta

7 October 2017

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7 October 2017

1390

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7 October 2017

1

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7 October 2017

85-102

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Cytotoxic activity of the thioether phospholipid analogue BM 41.440 in primary human tumor cultures

7 October 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2897%2900163-X

Inhibition of protein kinase C by ether-linked lipids is not correlated with their antineoplastic activity on WEHI-3B and R6X-B15 cells.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2897%2900163-X

Antitumor activity of SRI 62-834, a cyclic ether analog of ET-18-OCH3.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2897%2900163-X

Inhibition of the growth of human lung cancer cells by alkyl-lysophospholipid analogs

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2897%2900163-X

Phospholipid antitumor agents

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2897%2900163-X

Analogs of alkyllysophospholipids: chemistry, effects on the molecular level and their consequences for normal and malignant cells.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2897%2900163-X

Advances in either phospholipids treatment of cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2897%2900163-X

Unidirectional membrane uptake of the ether lipid antineoplastic agent edelfosine by L1210 cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2897%2900163-X

Membrane-interactive lipids as experimental anticancer drugs

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2897%2900163-X

The phospholipid analogue hexadecylphosphocholine inhibits phosphatidylcholine biosynthesis in Madin-Darby canine kidney cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2897%2900163-X

Modulation of CTP:phosphocholine cytidylyltransferase translocation by oleic acid and the antitumoral alkylphospholipid in HL-60 cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2897%2900163-X

The effect of edelfosine on CTP:cholinephosphate cytidylyltransferase activity in leukemic cell lines

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2897%2900163-X

The ether lipid 1-octadecyl-2-methyl-rac-glycero-3-phosphocholine induces expression of fos and jun proto-oncogenes and activates AP-1 transcription factor in human leukaemic cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2897%2900163-X

Platelet-activating factor and its methoxy-analogue ET-18-OCH3 stimulate immediate early gene expression in rat astroglial cultures

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2897%2900163-X

Effect of 1-O -Octadecyl-2-O -Methyl-Glycerophosphocholine on Phosphatidylcholine and Phosphatidylethanolamine Synthesis in MCF-7 and A549 Cells and its Relationship to Inhibition of Cell Proliferation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2897%2900163-X

O-alkyl-O-methylglycerophosphocholine, an antineoplastic lipid, undergoes spontaneous redistribution between biological membranes prepared from HL-60 cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2897%2900163-X

The regulation of tyrosine kinase signalling pathways by growth factor and G-protein-coupled receptors.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2897%2900163-X

Signal-transducing protein phosphorylation cascades mediated by Ras/Rho proteins in the mammalian cell: the potential for multiplex signalling

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2897%2900163-X

7 January 2021

Phospholipid signaling

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https://api.crossref.org/works/10.1016%2FS0005-2760%2897%2900163-X

Dimerization of cell surface receptors in signal transduction

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2897%2900163-X

Protein modules and signalling networks

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2897%2900163-X

Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2897%2900163-X

Transcriptional regulation by extracellular signals: mechanisms and specificity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2897%2900163-X

G beta gamma interactions with PH domains and Ras-MAPK signaling pathways

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2897%2900163-X

Tyrosine phosphorylation: past, present and future

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2897%2900163-X

Signal transduction and TGF-beta superfamily receptors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2897%2900163-X

Cytokine signaling through nonreceptor protein tyrosine kinases

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2897%2900163-X

Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2897%2900163-X

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2897%2900163-X

Signal integration at the level of protein kinases, protein phosphatases and their substrates

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2897%2900163-X

1-O-octadecyl-2-O-methyl-glycerophosphocholine inhibits the transduction of growth signals via the MAPK cascade in cultured MCF-7 cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2897%2900163-X

Characterization of a scintillation proximity assay to detect modulators of transforming growth factor alpha (TGF alpha) binding

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2897%2900163-X

Hemopoietic cell growth factors and their receptors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2897%2900163-X

Receptor for transferrin may be a "target" structure for natural killer cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2897%2900163-X

7 January 2021

Lipid second messengers

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2897%2900163-X

Inositol trisphosphate and calcium signalling

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2897%2900163-X

Inositol-lipid-specific phospholipase C isoenzymes and their differential regulation by receptors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2897%2900163-X

Activation of the β1 isozyme of phospholipase C by α subunits of the Gq class of G proteins

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2897%2900163-X

Stimulation of phospholipase C by guanine-nucleotide-binding protein beta gamma subunits.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2897%2900163-X

Subunits beta gamma of heterotrimeric G protein activate beta 2 isoform of phospholipase C

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2897%2900163-X

Regulation of polyphosphoinositide-specific phospholipase C activity by purified Gq.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2897%2900163-X

Phospholipase C-gamma is a substrate for the PDGF and EGF receptor protein-tyrosine kinases in vivo and in vitro

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2897%2900163-X

Oncogenes and signal transduction

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2897%2900163-X

A dual functional signal mediator showing RhoGAP and phospholipase C-delta stimulating activities

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2897%2900163-X

Inhibition of phospholipase C delta by hexadecylphosphorylcholine and lysophospholipids with antitumor activity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2897%2900163-X

A new phospholipase C delta 4 is induced at S-phase of the cell cycle and appears in the nucleus

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2897%2900163-X

Inhibition of cellular transport systems by alkyl phospholipid analogs in HL-60 human leukemia cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2897%2900163-X

S-phase induction and transformation of quiescent NIH 3T3 cells by microinjection of phospholipase C

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2897%2900163-X

Inhibition of serum- and ras-stimulated DNA synthesis by antibodies to phospholipase C.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2897%2900163-X

Point mutation in FGF receptor eliminates phosphatidylinositol hydrolysis without affecting mitogenesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2897%2900163-X

Effect of phospholipase C-gamma overexpression on PDGF-induced second messengers and mitogenesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2897%2900163-X

Overexpression of phospholipase C-gamma in NIH 3T3 fibroblasts results in increased phosphatidylinositol hydrolysis in response to platelet-derived growth factor and basic fibroblast growth factor

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2897%2900163-X

Point mutation of an FGF receptor abolishes phosphatidylinositol turnover and Ca2+ flux but not mitogenesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2897%2900163-X

Colworth Medal Lecture. Molecules mediating signals

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2897%2900163-X

Phosphatidylinositol 3-kinase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2897%2900163-X

Role of PI 3-kinase in mitogenesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2897%2900163-X

Activation of phosphatidylinositol 3-kinase by insulin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2897%2900163-X

R-Ras can activate the phosphoinositide 3-kinase but not the MAP kinase arm of the Ras effector pathways.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2897%2900163-X

Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2897%2900163-X

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2897%2900163-X

A target for Pl(3) kinase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2897%2900163-X

p70 S6 kinase: an enigma with variations

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2897%2900163-X

Phospholipase D: role in signal transduction and membrane traffic

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2897%2900163-X

The antitumor phospholipid analog, hexadecylphosphocholine, activates cellular phospholipase D

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2897%2900163-X

Role of Ca2+ in toxic cell killing

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2897%2900163-X

Interactions between alkylglycerols and human neutrophil granulocytes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2897%2900163-X

The role of intracellular free calcium mobilization in the mechanism of action of antitumour ether lipids SRI 62-834 and ET18-OMe.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2897%2900163-X

Ether lipid-induced cell damage of neuroblastoma cells is only weakly correlated with increased intracellular Ca2+ levels.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2897%2900163-X

Protein kinase C and lipid signaling for sustained cellular responses

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2897%2900163-X

Mechanism of interaction of protein kinase C with phorbol esters. Reversibility and nature of membrane association

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2897%2900163-X

Protein kinase C in the transduction of signals toward and within the cell nucleus

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2897%2900163-X

Protein kinase C activates the MEK-ERK pathway in a manner independent of Ras and dependent on Raf.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2897%2900163-X

Protein kinase C alpha activates RAF-1 by direct phosphorylation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2897%2900163-X

Role of diacylglycerol-regulated protein kinase C isotypes in growth factor activation of the Raf-1 protein kinase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2897%2900163-X

G(o)-protein alpha-subunits activate mitogen-activated protein kinase via a novel protein kinase C-dependent mechanism.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2897%2900163-X

Regulation of the NF-kappa B/rel transcription factor and I kappa B inhibitor system

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2897%2900163-X

NF-kappa B: a lesson in family values

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2897%2900163-X

Phosphatidylcholine breakdown and signal transduction

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2897%2900163-X

The phospholipid analogue, hexadecylphosphocholine, inhibits protein kinase C in vitro and antagonises phorbol ester-stimulated cell proliferation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2897%2900163-X

Inhibition of calcium-dependent protein kinase C by hexadecylphosphocholine and 1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine do not correlate with inhibition of proliferation of HL60 and K562 cell lines

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2897%2900163-X

Alkyllysophospholipid ET-18-OCH3 acts as an activator of protein kinase C in HL-60 cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2897%2900163-X

Effects of hexadecylphosphocholine on protein kinase C and TPA-induced differentiation of HL60 cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2897%2900163-X

Effect of a selective protein kinase C inhibitor, Ro 31-8425, on Mac-1 expression and adhesion of human neutrophils

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2897%2900163-X

Protein kinase C: is its pivotal role in cellular activation over-stated?

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2897%2900163-X

Protein kinase C is not involved in the cytotoxic action of 1-octadecyl-2-O-methyl-sn-glycerol-3-phosphocholine in HL-60 and K562 cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2897%2900163-X

1-O-Octadecyl-2-O-methylglycerophosphocholine inhibits protein kinase C-dependent phosphorylation of endogenous proteins in MCF-7 cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2897%2900163-X

The phosphatidylinositol 3-kinase inhibitor, wortmannin, inhibits insulin-induced activation of phosphatidylcholine hydrolysis and associated protein kinase C translocation in rat adipocytes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2897%2900163-X

Antileukemic agent alkyllysophospholipid regulates phosphorylation of distinct proteins in HL60 and K562 cells and differentiation of HL60 cells promoted by phorbol ester

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2897%2900163-X

Metabolism of alkyl lysophospholipid in epithelial cancer cell lines and inhibition of cell growth

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2897%2900163-X

The MAP kinase cascade is essential for diverse signal transduction pathways

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2897%2900163-X

Diversity in function and regulation of MAP kinase pathways

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2897%2900163-X

Linkage of G protein-coupled receptors to the MAPK signaling pathway through PI 3-kinase gamma

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2897%2900163-X

Restoration of tRNA3Lys-primed(-)-strand DNA synthesis to an HIV-1 reverse transcriptase mutant with extended tRNAs. Implications for retroviral replication

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2897%2900163-X

Hydrolysis of phosphatidylcholine couples Ras to activation of Raf protein kinase during mitogenic signal transduction

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2897%2900163-X

Ceramide-binding and activation defines protein kinase c-Raf as a ceramide-activated protein kinase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2897%2900163-X

Raf-1 is activated during mitosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2897%2900163-X

The protein kinase C inhibitor ilmofosine (BM 41 440) arrests cells in G2 phase and suppresses CDC2 kinase activation through a mechanism different from that of DNA damaging agents

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2897%2900163-X

Signalling pathways as targets for anticancer drug development

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2897%2900163-X

Cellular uptake and metabolic fate of hexadecylphosphocholine

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2897%2900163-X

Receptor tyrosine kinases

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2760%2897%2900163-X

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1016/S0005-2760(97)00163-X

1 reference

7 October 2017

1 reference

PubMed ID

9487143