IKZF1 deletion is an independent prognostic marker in childhood B-cell precursor acute lymphoblastic leukemia, and distinguishes patients benefiting from pulses during maintenance therapy: results of the EORTC Children's Leukemia Group study 58951. (Q41688725)

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scientific article published on 8 June 2015

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English	IKZF1 deletion is an independent prognostic marker in childhood B-cell precursor acute lymphoblastic leukemia, and distinguishes patients benefiting from pulses during maintenance therapy: results of the EORTC Children's Leukemia Group study 58951.	scientific article published on 8 June 2015

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scholarly article

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Europe PubMed Central

7 October 2017

IKZF1 deletion is an independent prognostic marker in childhood B-cell precursor acute lymphoblastic leukemia, and distinguishes patients benefiting from pulses during maintenance therapy: results of the EORTC Children's Leukemia Group study 58951. (English)

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7 October 2017

lymphoblastic leukemia

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based on heuristic

inferred from title

Nathalie Grardel

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E Clappier

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J Rapion

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B De Moerloose

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P Kastner

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A Caye

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J Vivent

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V Costa

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A Ferster

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P Lutz

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F Mazingue

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F Millot

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D Plantaz

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G Plat

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E Plouvier

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M Poirée

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N Sirvent

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A Uyttebroeck

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K Yakouben

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S Girard

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N Dastugue

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S Suciu

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Y Benoit

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Y Bertrand

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European Organisation for Research and Treatment of Cancer, Children's Leukemia Group (EORTC-CLG)

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publication date

8 June 2015

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7 October 2017

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2154-2161

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https://scigraph.springernature.com/pub.10.1038/leu.2015.134

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Acute lymphoblastic leukaemia

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21 January 2018

Long-term results of the children's cancer group studies for childhood acute lymphoblastic leukemia 1983-2002: a Children's Oncology Group Report

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A 50-year journey to cure childhood acute lymphoblastic leukemia

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Outcomes of children with BCR-ABL1–like acute lymphoblastic leukemia treated with risk-directed therapy based on the levels of minimal residual disease

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https://api.crossref.org/works/10.1038%2FLEU.2015.134

21 January 2018

The clinical relevance of chromosomal and genomic abnormalities in B-cell precursor acute lymphoblastic leukaemia

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https://api.crossref.org/works/10.1038%2FLEU.2015.134

21 January 2018

Predicting relapse risk in childhood acute lymphoblastic leukaemia

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https://api.crossref.org/works/10.1038%2FLEU.2015.134

21 January 2018

Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia

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https://api.crossref.org/works/10.1038%2FLEU.2015.134

21 January 2018

Deletion of IKZF1 and prognosis in acute lymphoblastic leukemia

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https://api.crossref.org/works/10.1038%2FLEU.2015.134

21 January 2018

IKZF1 deletions predict relapse in uniformly treated pediatric precursor B-ALL.

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21 January 2018

IKZF1 deletion is an independent predictor of outcome in pediatric acute lymphoblastic leukemia treated according to the ALL-BFM 2000 protocol

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https://api.crossref.org/works/10.1038%2FLEU.2015.134

21 January 2018

Impact of IKZF1 deletions on IKZF1 expression and outcome in Philadelphia chromosome negative childhood BCP-ALL. Reply to "incidence and biological significance of IKZF1/Ikaros gene deletions in pediatric Philadelphia chromosome negative and Philade

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https://api.crossref.org/works/10.1038%2FLEU.2015.134

21 January 2018

Outcome modeling with CRLF2, IKZF1, JAK, and minimal residual disease in pediatric acute lymphoblastic leukemia: a Children's Oncology Group study

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2015.134

21 January 2018

Improved outcome with pulses of vincristine and corticosteroids in continuation therapy of children with average risk acute lymphoblastic leukemia (ALL) and lymphoblastic non-Hodgkin lymphoma (NHL): report of the EORTC randomized phase 3 trial 58951

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21 January 2018

Dexamethasone (6 mg/m2/day) and prednisolone (60 mg/m2/day) were equally effective as induction therapy for childhood acute lymphoblastic leukemia in the EORTC CLG 58951 randomized trial

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https://api.crossref.org/works/10.1038%2FLEU.2015.134

21 January 2018

Imatinib after induction for treatment of children and adolescents with Philadelphia-chromosome-positive acute lymphoblastic leukaemia (EsPhALL): a randomised, open-label, intergroup study

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21 January 2018

IKZF1 status as a prognostic feature in BCR-ABL1-positive childhood ALL.

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A competitive PCR-based method using TCRD, TCRG and IGH rearrangements for rapid detection of patients with high levels of minimal residual disease in acute lymphoblastic leukemia.

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21 January 2018

An intragenic ERG deletion is a marker of an oncogenic subtype of B-cell precursor acute lymphoblastic leukemia with a favorable outcome despite frequent IKZF1 deletions.

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21 January 2018

Breakpoint-specific multiplex polymerase chain reaction allows the detection of IKZF1 intragenic deletions and minimal residual disease monitoring in B-cell precursor acute lymphoblastic leukemia.

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21 January 2018

ERG deletion is associated with CD2 and attenuates the negative impact of IKZF1 deletion in childhood acute lymphoblastic leukemia.

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21 January 2018

Pulses of vincristine and dexamethasone in addition to intensive chemotherapy for children with intermediate-risk acute lymphoblastic leukaemia: a multicentre randomised trial

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21 January 2018

Integrated use of minimal residual disease classification and IKZF1 alteration status accurately predicts 79% of relapses in pediatric acute lymphoblastic leukemia

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21 January 2018

A subtype of childhood acute lymphoblastic leukaemia with poor treatment outcome: a genome-wide classification study

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Identification of novel cluster groups in pediatric high-risk B-precursor acute lymphoblastic leukemia with gene expression profiling: correlation with genome-wide DNA copy number alterations, clinical characteristics, and outcome

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Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia

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Genetic alterations activating kinase and cytokine receptor signaling in high-risk acute lymphoblastic leukemia

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Beyond Philadelphia: 'Ph-like' B cell precursor acute lymphoblastic leukemias - diagnostic challenges and therapeutic promises

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21 January 2018

Independent prognostic value of BCR-ABL1-like signature and IKZF1 deletion, but not high CRLF2 expression, in children with B-cell precursor ALL.

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RAG-mediated recombination is the predominant driver of oncogenic rearrangement in ETV6-RUNX1 acute lymphoblastic leukemia

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10.1038/LEU.2015.134

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