Bcl-2 overexpression does not protect neurons from mutant neurofilament-mediated motor neuron degeneration (Q41680641)

7 October 2017

Bcl-2 overexpression does not protect neurons from mutant neurofilament-mediated motor neuron degeneration (English)

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7 October 2017

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Houseweart MK

1

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7 October 2017

Cleveland DW

series ordinal

2

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7 October 2017

language of work or name

English

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publication date

1 August 1999

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7 October 2017

Journal of Neuroscience

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7 October 2017

19

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7 October 2017

15

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7 October 2017

6446-6456

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Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species

7 October 2017

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12 December 2020

SOD1 mutation is associated with accumulation of neurofilaments in amyotrophic lateral sclerosis.

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12 December 2020

The protooncogene bcl-2 inhibits apoptosis in PC12 cells

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12 December 2020

Prevention of programmed cell death of sympathetic neurons by the bcl-2 proto-oncogene

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12 December 2020

A mutant neurofilament subunit causes massive, selective motor neuron death: implications for the pathogenesis of human motor neuron disease

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12 December 2020

Delayed maturation of regenerating myelinated axons in mice lacking neurofilaments

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12 December 2020

Reduced diameter and conduction velocity of myelinated fibers in the sciatic nerve of a neurofilament-deficient mutant quail

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12 December 2020

Ultrastructure of chromatolytic motoneurons and anterior spinal roots in a case of Werdnig-Hoffmann disease.

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12 December 2020

Altered expression of bcl-2 and bax mRNA in amyotrophic lateral sclerosis spinal cord motor neurons

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12 December 2020

bcl-2 inhibits death of central neural cells induced by multiple agents

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12 December 2020

Overexpression of BCL-2 in transgenic mice protects neurons from naturally occurring cell death and experimental ischemia

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12 December 2020

Intense superoxide dismutase-1 immunoreactivity in intracytoplasmic hyaline inclusions of familial amyotrophic lateral sclerosis with posterior column involvement.

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12 December 2020

Transgenic mice carrying a human mutant superoxide dismutase transgene develop neuronal cytoskeletal pathology resembling human amyotrophic lateral sclerosis lesions

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12 December 2020

Absence of neurofilaments reduces the selective vulnerability of motor neurons and slows disease caused by a familial amyotrophic lateral sclerosis-linked superoxide dismutase 1 mutant

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12 December 2020

Slowing of axonal transport is a very early event in the toxicity of ALS-linked SOD1 mutants to motor neurons

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12 December 2020

Protective effect of neurofilament heavy gene overexpression in motor neuron disease induced by mutant superoxide dismutase

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12 December 2020

Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation

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12 December 2020

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12 December 2020

Mutation in neurofilament transgene implicates RNA processing in the pathogenesis of neurodegenerative disease

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12 December 2020

Mutations associated with amyotrophic lateral sclerosis convert superoxide dismutase from an antiapoptotic gene to a proapoptotic gene: studies in yeast and neural cells

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12 December 2020

BCL-2 family: regulators of cell death

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12 December 2020

Bcl-2 functions in an antioxidant pathway to prevent apoptosis

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12 December 2020

DNA-fragmentation and apoptosis-related proteins of muscle cells in motor neuron disorders

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12 December 2020

Proximal axonal enlargement in motor neuron disease.

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12 December 2020

Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme

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12 December 2020

Apoptosis in amyotrophic lateral sclerosis is not restricted to motor neurons. Bcl-2 expression is increased in unaffected post-central gyrus

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12 December 2020

Motor neuron disease: quantitative morphological and microdensitophotometric studies of neurons of anterior horn and ventral root of cervical spinal cord with special reference to the pathogenesis

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12 December 2020

Progressive neuronopathy in transgenic mice expressing the human neurofilament heavy gene: a mouse model of amyotrophic lateral sclerosis

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12 December 2020

Bcl-2 sensitivity differentiates two pathways for motoneuronal death in the wobbler mutant mouse

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12 December 2020

Inhibition of ICE slows ALS in mice

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12 December 2020

Morphometric Comparison of the Vulnerability of Peripheral Motor and Sensory Neurons in Amyotrophic Lateral Sclerosis

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12 December 2020

Increased expression of neurofilament subunit NF-L produces morphological alterations that resemble the pathology of human motor neuron disease

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12 December 2020

Assembly properties of dominant and recessive mutations in the small mouse neurofilament (NF-L) subunit

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12 December 2020

Hereditary hypotrophic axonopathy with neurofilament deficiency in a mutant strain of the Japanese quail

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12 December 2020

Aggregation of mutant Cu/Zn superoxide dismutase proteins in a culture model of ALS

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12 December 2020

Bcl-2: prolonging life in a transgenic mouse model of familial amyotrophic lateral sclerosis

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12 December 2020

Fine structural observations of neurofilamentous changes in amyotrophic lateral sclerosis

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12 December 2020

bcl-2 protein expression is widespread in the developing nervous system and retained in the adult PNS.

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12 December 2020

Fine structural study of neurofibrillary changes in a family with amyotrophic lateral sclerosis

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12 December 2020

An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria

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12 December 2020

Neurofilament gene expression: a major determinant of axonal caliber

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12 December 2020

Mechanisms controlling cellular suicide: role of Bcl-2 and caspases.

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12 December 2020

Actions of CNTF and neurotrophins on degenerating motoneurons: preclinical studies and clinical implications.

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12 December 2020

The proto-oncogene bcl-2 can selectively rescue neurotrophic factor-dependent neurons from apoptosis.

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12 December 2020

ALS-linked SOD1 mutant G85R mediates damage to astrocytes and promotes rapidly progressive disease with SOD1-containing inclusions.

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12 December 2020

Bcl-2 overexpression prevents motoneuron cell body loss but not axonal degeneration in a mouse model of a neurodegenerative disease

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12 December 2020

Identifiers

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